Patents by Inventor Han-Lie Chia

Han-Lie Chia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4873074
    Abstract: Stable injection solutions of radiodiagnostic aids ready for use are obtained by addition to the organ- or tissue-specific carrier, before, during of after the labeling with the pertechnetate, of a compound of the formula: ##STR1## in which R denotes hydrogen, and R' denotes a sulpho- or a carboxymethyl group, or R and R' each denote a sulpho- or a carboxymethyl group, or a water-soluble salt thereof, as stabilizer. These compounds do not alter the specific organ or tissue distribution of the carrier.
    Type: Grant
    Filed: January 31, 1989
    Date of Patent: October 10, 1989
    Assignee: Solco Basel
    Inventors: Han-Lie Chia, Horia Popescu, Gabrielle Boehmer
  • Patent number: 4857299
    Abstract: Stable injection solutions of radiodiagnostic aids ready for use are obtained by addition to the organ-or tissue-specific carrier, before, during or after the labeling with the pertechnetate, of a compound of the formula: ##STR1## in which R denotes hydrogen, and R' denotes a sulpho- or a carboxymethyl group, or R and R' each denote a sulpho- or a carboxymethyl group, or a water-soluble salt thereof, as stabilizer. These compounds do not alter the specific organ or tissue distribution of the carrier.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: August 15, 1989
    Assignee: Solco Basel AG
    Inventors: Han-Lie Chia, Horia Popescu, Gabrielle Boehmer
  • Patent number: 4410507
    Abstract: A colloidal solution of human serum albumin is prepared by mixing an aqueous solution of the latter with a non-ionic surface-active agent and an acid solution of a tin(II) salt, adjusting the pH to 3.5 to 8.0 and heating at a constant temperature between 45.degree. and 100.degree. C. until complete hydrolysis of the tin(II) salt and denaturation of the albumin have taken place; the colloidal solution can also be lyophilized. By treating the solution or the lyophilizate with a .sup.99m Tc-pertechnetate solution, a colloidal preparation is obtained for scintigraphy of the reticuloendothelial system or the lymphatic system. By suitable pH adjustment, the process makes it possible selectively to obtain colloids with a particle size of, for example, 3.0-0.2 or 0.2-0.03 or below 0.03 .mu.m.
    Type: Grant
    Filed: December 30, 1981
    Date of Patent: October 18, 1983
    Assignee: Solco Basel AG
    Inventors: Han-Lie Chia, Siegfried Woltmann