Patents by Inventor Han Marquardt

Han Marquardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oncostatin M and novel compositions having anti-neoplastic activity
    Patent number: 5120535
    Abstract: Novel compositions are provided for modulating growth, particularly of tumor cells, which compositions are combinations of Oncostatin M, and one or both of transforming growth factors or .gamma.-interferons, or analogs thereof. In addition, a novel transforming growth factor is provided, designated TGF-.beta.2, as well as methods for its preparation.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: June 9, 1992
    Assignee: Oncogen
    Inventors: Hans Marquardt, Joyce M. Zarling, Mohammed Shoyab, Marcia B. Hanson, Mario N. Lioubin, Thomas J. Brown, Tatsuhiko Ikeda
  • Vectors encoding brain derivable polypeptide factors
    Patent number: 5011777
    Abstract: Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The low molecular weight polypeptides either are growth inhibitors for neoplastic cells without inhibiting normal cells or affect GABA-ergic transmission. The polypeptides find use in inhibiting neoplastic growth, modulating diazepam receptor response, and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the polypeptides.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: April 30, 1991
    Assignee: Oncogen
    Inventors: Mohammed Shoyab, Hans Marquardt, George J. Todaro
  • Brain derivable polypeptide factors and antibodies thereto
    Patent number: 4963485
    Abstract: Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The low molecular weight polypeptides either are growth inhibitors for neoplastic cells without inhibiting normal cells or affect GABA-ergic transmission. The polypeptides find use in inhibiting neoplastic growth, modulating diazepam receptor response, and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the polypeptides.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: October 16, 1990
    Assignee: Oncogen
    Inventors: Mohammed Shoyab, Hans Marquardt, George J. Todaro
  • Polypeptide tumor inhibitors and antibodies thereto
    Patent number: 4806492
    Abstract: Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The small molecular weight polypeptides are growth inhibitors for neoplastic cells without inhibiting normal cells. The polypeptides comprise specific regions which are highly conserved, separated by less conserved regions. The polypeptides find use in inhibiting neoplastic growth and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the neoplastic cell retarding polypeptides.
    Type: Grant
    Filed: August 15, 1985
    Date of Patent: February 21, 1989
    Assignee: Oncogen, Inc.
    Inventors: Mohammed Shoyab, Hans Marquardt, George J. Todaro
  • Snake venom growth arresting peptide
    Patent number: 4774318
    Abstract: Novel cytotoxic agents are provided as small polypeptides related to a low molecular weight peptide derived from Crotalus atrox. The compounds may be used by themselves or in combination with other reagents, such as antibodies, for inhibiting cell growth.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: September 27, 1988
    Assignee: Oncogen
    Inventors: Hans Marquardt, George J. Todaro, Daniel R. Twardzik
  • Snake venom growth arresting peptide
    Patent number: 4731439
    Abstract: Novel cytotoxic agents are provided as small polypeptides related to a low molecular weight peptide derived from Crotalus atrox. The compounds may be used by themselves or in combination with other reagents, such as antibodies, for inhibiting cell growth.
    Type: Grant
    Filed: November 22, 1985
    Date of Patent: March 15, 1988
    Assignee: Oncogen
    Inventors: Hans Marquardt, George J. Todaro, Daniel R. Twardzik
  • Polypeptide tumor inhibitors and antibodies thereto
    Patent number: 4714683
    Abstract: Polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The small molecular weight polypeptides are growth inhibitors for neoplastic cells without inhibiting normal cells. The polypeptides comprise specific regions which are highly conserved, separated by less conserved regions. The polypeptides find use in inhibiting neoplastic growth and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the neoplastic cell retarding polypeptides.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: December 22, 1987
    Assignee: Oncogen
    Inventors: Mohammed Shoyab, Hans Marquardt, George J. Todaro