Abstract: The present disclosure includes cationic carrier units comprising (i) a water soluble polymer, (ii) a positively charged carrier, and (iii) an adjuvant moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.

Abstract: The present disclosure includes cationic carrier units comprising (i) a water-soluble polymer, (ii) a positively charged carrier, (iii) a hydrophobic moiety, and (iv) a crosslinking moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.

Abstract: The present disclosure includes cationic carrier units comprising (i) a water soluble polymer, (ii) a positively charged carrier, (iii) a hydrophobic moiety, and (iv) a crosslinking moeity, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an RNA and/or DNA) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.

Abstract: Provided are a novel boron-containing compound and an electrolyte solution additive for a secondary battery including the same. The electrolyte solution for a secondary battery provided in one embodiment includes the novel boron-containing compound, thereby suppressing the decomposition of an electrolyte solution to improve the capacity and the life characteristics of a battery.

Abstract: Disclosed is a method and apparatus for measuring a distance to a target object by using a radar signal in an environment where an obstacle is present. The disclosed method of measuring a distance by using a radar includes: receiving a radar signal reflected from a target object by passing through a target obstacle; estimating material of the target obstacle by using an obstacle material learning result which uses a waveform of a reference radar signal, and by using a waveform of the reflected radar signal; estimating a thickness of the target obstacle by using an obstacle thickness learning result which uses a frequency feature of the reference radar signal, and by using a frequency feature of the reflected radar signal; and calculating a distance to the target object by using a permittivity according to the material of the target obstacle, and the thickness of the target obstacle.

Abstract: Disclosed is a method and apparatus for measuring a distance to a target object by using a radar signal in an environment where an obstacle is present. The disclosed method of measuring a distance by using a radar includes: receiving a radar signal reflected from a target object by passing through a target obstacle; estimating material of the target obstacle by using an obstacle material learning result which uses a waveform of a reference radar signal, and by using a waveform of the reflected radar signal; estimating a thickness of the target obstacle by using an obstacle thickness learning result which uses a frequency feature of the reference radar signal, and by using a frequency feature of the reflected radar signal; and calculating a distance to the target object by using a permittivity according to the material of the target obstacle, and the thickness of the target obstacle.