Patents by Inventor Han W. Tun

Han W. Tun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR TREATING CANCER
    Publication number: 20230310419
    Abstract: The present application provides methods and compositions for treating cancer, for example, renal cell carcinoma, melanoma, ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancer, and more particularly to using an inhibitor of a stearoyl-Coenzyme A desaturase 1 (SCD1) enzyme in combination with a checkpoint inhibitor to treat these disorders.
    Type: Application
    Filed: January 26, 2023
    Publication date: October 5, 2023
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: John A. Copland, III, Christina Von Roemeling, Han W. Tun, Thomas R. Caulfield, Yon Son Betty Kim
  • Compounds and methods for treating cancer
    Patent number: 11596629
    Abstract: The present application provides methods and compositions for treating cancer, for example, renal cell carcinoma, melanoma, ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancer, and more particularly to using an inhibitor of a stearoyl-Coenzyme A desaturase 1 (SCD1) enzyme in combination with a checkpoint inhibitor to treat these disorders.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: March 7, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John A. Copland, III, Christina Von Roemeling, Han W. Tun, Thomas R. Caulfield, Yon Son Kim
  • COMPOUNDS AND METHODS FOR TREATING CANCER
    Publication number: 20220411389
    Abstract: This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
    Type: Application
    Filed: April 5, 2022
    Publication date: December 29, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: John A. Copland, III, Han W. Tun, Thomas R. Caulfield, Christina Von Roemeling, Laura Ann Marlow
  • Compounds and methods for treating cancer
    Patent number: 11325892
    Abstract: This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: May 10, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John A. Copland, III, Han W. Tun, Thomas R. Caulfield, Christina Von Roemeling, Laura Ann Marlow
  • COMPOUNDS AND METHODS FOR TREATING CANCER
    Publication number: 20200061055
    Abstract: The present application provides methods and compositions for treating cancer, for example, renal cell carcinoma, melanoma, ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancer, and more particularly to using an inhibitor of a stearoyl-Coenzyme A desaturase 1 (SCD1) enzyme in combination with a checkpoint inhibitor to treat these disorders.
    Type: Application
    Filed: February 28, 2018
    Publication date: February 27, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Christina Von Roemeling, Han W. Tun, John A. Copland, III, Thomas R. Caulfield, Yon Son Betty Kim
  • COMPOUNDS AND METHODS FOR TREATING CANCER
    Publication number: 20190345123
    Abstract: This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
    Type: Application
    Filed: May 24, 2019
    Publication date: November 14, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: John A. Copland, III, Han W. Tun, Thomas R. Caulfield, Christina Von Roemeling, Laura Ann Marlow
  • Compounds and methods for treating cancer
    Patent number: 10301273
    Abstract: This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: May 28, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John A. Copland, III, Han W. Tun, Thomas R. Caulfield, Christina Von Roemeling, Laura Ann Marlow
  • Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers
    Patent number: 9839632
    Abstract: Methods and compositions for treating, preventing or managing central nervous system cancers are disclosed. The methods encompass the administration of 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione, also known as Pomalidomide. Furthermore, provided herein are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: December 12, 2017
    Assignee: Celgene Corporation
    Inventor: Han W. Tun
  • COMPOUNDS AND METHODS FOR TREATING CANCER
    Publication number: 20170226073
    Abstract: This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
    Type: Application
    Filed: August 7, 2015
    Publication date: August 10, 2017
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: John A. Copland, III, Han W. Tun, Thomas R. Caulfield, Christina Von Roemeling, Laura Ann Marlow
  • Substituted imidazo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazines and oxazolo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazines for treating brain cancer
    Patent number: 9464093
    Abstract: This document relates to compounds and compositions useful for treating cancers, such as brain and nervous system cancers.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: October 11, 2016
    Assignees: Mayo Foundation for Medical Education and Research, Osaka University
    Inventors: Han W. Tun, Takehiko Yoshimitsu, Daisuke Shigeoka, Takuma Kamon, Zhimin Li, Yushi Qiu, Thomas R. Caulfield
  • METHODS AND COMPOSITIONS USING 4-AMINO-2-(2,6-DIOXO-PIPERIDINE-3-YL)-ISOINDOLINE-1,3-DIONE FOR TREATMENT AND MANAGEMENT OF CENTRAL NERVOUS SYSTEM CANCERS
    Publication number: 20160045484
    Abstract: Methods and compositions for treating, preventing or managing central nervous system cancers are disclosed. The methods encompass the administration of 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione, also known as Pomalidomide. Furthermore, provided herein are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.
    Type: Application
    Filed: April 1, 2014
    Publication date: February 18, 2016
    Inventor: Han W. TUN
  • Treating Brain Cancer using Agelastatin A (AA) and Analogues Thereof
    Publication number: 20150274742
    Abstract: This document relates to compounds and compositions useful for treating cancers, such as brain and nervous system cancers.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 1, 2015
    Inventors: Han W. Tun, Takehiko Yoshimitsu, Daisuke Shigeoka, Takuma Kamon, Zhimin Li, Yushi Qiu, Thomas R. Caulfield