Patents by Inventor Han-Xiang Deng

Han-Xiang Deng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular targets for ALS and related disorders
    Patent number: 11041205
    Abstract: Provided herein are compositions and methods for diagnosis, risk assessment, research, and therapy related to amyotrophic lateral sclerosis (ALS) and ALS-related disorders. In particular, the present invention relates to mutations in the UBQLN2 gene that cause dominantly inherited chromosome X-linked ALS and ALS/dementia.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: June 22, 2021
    Assignee: Northwestern University
    Inventors: Teepu Siddique, Wenjie Chen, Han-Xiang Deng, Yi Yang
  • Allelic disorders caused by mutations in TRPV4
    Patent number: 9624544
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: April 18, 2017
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4
    Publication number: 20160102356
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Application
    Filed: December 17, 2015
    Publication date: April 14, 2016
    Applicant: Northwestern University
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • MOLECULAR TARGETS FOR ALS AND RELATED DISORDERS
    Publication number: 20160076102
    Abstract: Provided herein are compositions and methods for diagnosis, risk assessment, research, and therapy related to amyotrophic lateral sclerosis (ALS) and ALS-related disorders. In particular, the present invention relates to mutations in the UBQLN2 gene that cause dominantly inherited chromosome X-linked ALS and ALS/dementia.
    Type: Application
    Filed: September 18, 2015
    Publication date: March 17, 2016
    Applicant: Northwestern University
    Inventors: Teepu Siddique, Wenjie Chen, Han-Xiang Deng, Yi Yang
  • Allelic disorders caused by mutations in TRPV4
    Patent number: 9228236
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: January 5, 2016
    Assignee: Northwestern University
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • Molecular targets for ALS and related disorders
    Patent number: 9173897
    Abstract: Provided herein are compositions and methods for diagnosis, risk assessment, research, and therapy related to amyotrophic lateral sclerosis (ALS) and ALS-related disorders. In particular, the present invention relates to mutations in the UBQLN2 gene that cause dominantly inherited chromosome X-linked ALS and ALS/dementia.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: November 3, 2015
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Teepu Siddique, Wenjie Chen, Han-Xiang Deng, Yi Yang
  • Methods for diagnosing scapuloperoneal spinal muscular atrophy or Charcot-Marie-Tooth disease type 2C by detecting mutations in TRPV4
    Patent number: 8394589
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: March 12, 2013
    Assignee: Northwestern University
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • MOLECULAR TARGETS FOR ALS AND RELATED DISORDERS
    Publication number: 20120141459
    Abstract: Provided herein are compositions and methods for diagnosis, risk assessment, research, and therapy related to amyotrophic lateral sclerosis (ALS) and ALS-related disorders. In particular, the present invention relates to mutations in the UBQLN2 gene that cause dominantly inherited chromosome X-linked ALS and ALS/dementia.
    Type: Application
    Filed: December 7, 2011
    Publication date: June 7, 2012
    Inventors: Teepu Siddique, Wenjie Chen, Han-Xiang Deng, Yi Yang
  • ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4
    Publication number: 20110151445
    Abstract: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C).
    Type: Application
    Filed: December 21, 2010
    Publication date: June 23, 2011
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Teepu Siddique, Han-Xiang Deng, Jianhua Yan
  • EXT2 gene
    Patent number: 6287802
    Abstract: EXT2 polypeptides and DNA (RNA) encoding such enzyme and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such EXT2 in the development of treatments for to hereditary multiple exotoses and cancers, such as chondrosarcoma, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: September 11, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Han Xiang Deng, Chao Hong Fan, Jiahui Xia
  • &agr;-Tocopherol transport protein: compositions and methods
    Patent number: 6268170
    Abstract: The present invention provides an isolated and purified &agr;-tocopherol transport protein polypeptide. Human recombinant &agr;-tocopherol transport protein, polynucleotides encoding human &agr;-tocopherol transport protein and methods of using &agr;-tocopherol transport protein polypeptides and polynucleotides are also provided.
    Type: Grant
    Filed: November 14, 1995
    Date of Patent: July 31, 2001
    Assignee: Northwestern University
    Inventors: Teepu Siddique, Afif Hentati, Han-Xiang Deng