Abstract: A portable device for thermal stimulation of tissue of a patient comprising a heat control element having a proximal side and a distal side wherein a temperature difference can be generated between the proximal side and the distal side, and wherein the proximal side is capable of contacting the tissue. A fan capable of exchanging heat with surrounding air and a heat sink coupled to the distal side are provided. At least one resilient element connected between the heat sink and the fan is also provided, for supporting the fan so as to prevent direct contact between the heat sink and the fan. Furthermore at least one temperature sensor and circuitry are provided, wherein the circuitry activates the heat control element using the at least one temperature sensor, so as to achieve a desired temperature stimulation of the tissue at a rate of substantially 1 degree Celsius per second.