Patents by Inventor Hanan Stein

Hanan Stein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Collagen producing plants and methods of generating and using same
    Patent number: 10626408
    Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: April 21, 2020
    Assignee: CollPlant Ltd.
    Inventors: Oded Shoseyov, Hanan Stein
  • Bacterial resistant transgenic plants having dysfunctional T3SS proteins
    Patent number: 10407692
    Abstract: A nucleic acid expression vector comprising a nucleic acid sequence encoding a dominant negative T3SS protein is disclosed. The nucleic acid expression vector further comprising a cis acting regulatory element capable of driving transcription of the nucleic acid sequence in a plant cell. Moreover, the dominant negative T3SS protein mediates assembly of a dysfunctional needle complex.
    Type: Grant
    Filed: May 28, 2017
    Date of Patent: September 10, 2019
    Assignee: Futuragene Israel Ltd.
    Inventors: Hanan Stein, Dror Avisar
  • Gall wasp control agents
    Patent number: 9970022
    Abstract: The present invention relates to the field of RNA-mediated gene silencing in insect species. The present invention is based, in part, on the inventors' sequencing of genes from eucalyptus invasive species gall wasp pests Leptocybe invasa (Li) and Ophelimus maskelli (Om). In certain aspects, the invention provides Li and Om nucleic acids, derivatives thereof and the use of such nucleic acids and derivatives as gall wasp control agents.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: May 15, 2018
    Assignee: Futuragene Israel Ltd.
    Inventors: Dror Avisar, Hanan Stein, Ziv Shani, Daniel Siegel
  • COLLAGEN PRODUCING PLANTS AND METHODS OF GENERATING AND USING SAME
    Publication number: 20180044692
    Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.
    Type: Application
    Filed: October 3, 2017
    Publication date: February 15, 2018
    Applicant: CollPlant Ltd.
    Inventors: Oded SHOSEYOV, Hanan STEIN
  • Bacterial resistant transgenic plants having dysfunctional T3SS proteins
    Patent number: 9856492
    Abstract: A nucleic acid expression vector comprising a nucleic acid sequence encoding a dominant negative T3SS protein is disclosed. The nucleic acid expression vector further comprising a cis acting regulatory element capable of driving transcription of the nucleic acid sequence in a plant cell. Moreover, the dominant negative T3SS protein mediates assembly of a dysfunctional needle complex.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: January 2, 2018
    Assignee: Futuragene Israel Ltd.
    Inventors: Hanan Stein, Dror Avisar
  • Collagen producing plants and methods of generating and using same
    Patent number: 9783816
    Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: October 10, 2017
    Assignee: CollPlant Ltd.
    Inventors: Oded Shoseyov, Hanan Stein
  • BACTERIAL RESISTANT TRANSGENIC PLANTS HAVING DYSFUNCTIONAL T3SS PROTEINS
    Publication number: 20170260542
    Abstract: A nucleic acid expression vector comprising a nucleic acid sequence encoding a dominant negative T3SS protein is disclosed. The nucleic acid expression vector further comprising a cis acting regulatory element capable of driving transcription of the nucleic acid sequence in a plant cell. Moreover, the dominant negative T3SS protein mediates assembly of a dysfunctional needle complex.
    Type: Application
    Filed: May 28, 2017
    Publication date: September 14, 2017
    Applicant: Futuragene Israel Ltd.
    Inventors: Hanan STEIN, Dror AVISAR
  • Methods of processing recombinant procollagen
    Patent number: 8759487
    Abstract: A method of generating atelocollagen is disclosed. The method comprises contacting a human telopeptide-comprising collagen with a protease selected from the group consisting of neutrase, subtilisin, ficin recombinant human trypsin and recombinant human pepsin, wherein said human telopeptide-comprising collagen is expressed in a non-animal cell, thereby generating the atelocollagen. Compositions comprising the atelocollagen generated thereby are also disclosed.
    Type: Grant
    Filed: October 26, 2008
    Date of Patent: June 24, 2014
    Assignee: CollPlant Ltd.
    Inventors: Oded Shoseyov, Hanan Stein, Michal Rosenthal, Or Dgany, Tamar Haya Tal, Amit Yaari
  • GALL WASP CONTROL AGENTS
    Publication number: 20140157455
    Abstract: The present invention relates to the field of RNA-mediated gene silencing in insect species. The present invention is based, in part, on the inventors' sequencing of genes from eucalyptus invasive species gall wasp pests Leptocybe invasa (Li) and Ophelimus maskelli (Om). In certain aspects, the invention provides Li and Om nucleic acids, derivatives thereof and the use of such nucleic acids and derivatives as gall wasp control agents.
    Type: Application
    Filed: March 30, 2012
    Publication date: June 5, 2014
    Applicant: FUTURAGENE ISRAEL LTD.
    Inventors: Dror Avisar, Hanan Stein, Ziv Shani, Daniel Siegel
  • BACTERIAL RESISTANT TRANSGENIC PLANTS HAVING DYSFUNCTIONAL T3SS PROTEINS
    Publication number: 20130347141
    Abstract: A nucleic acid expression vector comprising a nucleic acid sequence encoding a dominant negative T3SS protein is disclosed. The nucleic acid expression vector further comprising a cis acting regulatory element capable of driving transcription of the nucleic acid sequence in a plant cell. Moreover, the dominant negative T3SS protein mediates assembly of a dysfunctional needle complex.
    Type: Application
    Filed: March 1, 2012
    Publication date: December 26, 2013
    Applicant: FUTURAGENE ISRAEL LTD.
    Inventors: Hanan Stein, Dror Avisar
  • COLLAGEN PRODUCING PLANTS AND METHODS OF GENERATING AND USING SAME
    Publication number: 20130289243
    Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.
    Type: Application
    Filed: July 8, 2013
    Publication date: October 31, 2013
    Inventors: Oded SHOSEYOV, Hanan Stein
  • Collagen producing plants and methods of generating and using same
    Patent number: 8455717
    Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: June 4, 2013
    Assignee: CollPlant Ltd.
    Inventors: Oded Shoseyov, Hanan Stein
  • PEST-RESISTANT PLANTS CONTAINING A COMBINATION OF A SPIDER TOXIN AND A CHITINASE
    Publication number: 20130097731
    Abstract: An isolated polynucleotide is disclosed comprising: (i) a nucleic acid sequence encoding at least one toxic peptide, the toxic peptide being a spider toxin; and (ii) a nucleic acid sequence encoding a chitinase attached to a secretion signal sequence. Uses thereof and plants expressing same are also disclosed.
    Type: Application
    Filed: June 16, 2011
    Publication date: April 18, 2013
    Applicant: Futuragene Israel Ltd.
    Inventors: Dror Avisar, Hanan Stein, Ziv Shani
  • COLLAGEN PRODUCING PLANTS AND METHODS OF GENERATING AND USING SAME
    Publication number: 20120284817
    Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.
    Type: Application
    Filed: July 5, 2012
    Publication date: November 8, 2012
    Applicant: CollPlant Ltd.
    Inventors: Oded SHOSEYOV, Hanan Stein
  • METHODS OF PROCESSING RECOMBINANT PROCOLLAGEN
    Publication number: 20120065376
    Abstract: A method of generating atelocollagen is disclosed. The method comprises contacting a human telopeptide-comprising collagen with a protease selected from the group consisting of neutrase, subtilisin, ficin recombinant human trypsin and recombinant human pepsin, wherein said human telopeptide-comprising collagen is expressed in a non-animal cell, thereby generating the atelocollagen. Compositions comprising the atelocollagen generated thereby are also disclosed.
    Type: Application
    Filed: October 26, 2008
    Publication date: March 15, 2012
    Applicant: CollPlant Ltd.
    Inventors: Oded Shoseyov, Hanan Stein, Michal Rosenthal, Or Dgany, Tamar Haya Tal, Amit Yaari
  • Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby
    Patent number: 7385106
    Abstract: A method of generating a plant tolerant of environmental stress conditions, the method comprising the step of expressing within the plant exogenous polynucleotides encoding enzymes capable of catalyzing proline production, wherein the exogenous polynucleotides are expressed in a manner so as to allow accumulation of the enzymes within a subcellular organelle of the plant. The invention further describes novel polynucleotides and nucleic acid constructs useful in implementing the methods and a transgenic plant resultant therefrom.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: June 10, 2008
    Assignee: Ramot At Tel Aviv University Ltd.
    Inventors: Hanan Stein, Aviah Zilberstein, Gadi Miller, Yoram Kapulnik
  • Collagen producing plants and methods of generating and using same
    Publication number: 20070186312
    Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.
    Type: Application
    Filed: March 29, 2007
    Publication date: August 9, 2007
    Applicant: CollPlant Ltd.
    Inventors: Oded Shoseyov, Hanan Stein
  • Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby
    Publication number: 20030211490
    Abstract: A method of generating a plant tolerant of environmental stress conditions, the method comprising the step of expressing within the plant exogenous polynucleotides encoding enzymes capable of catalyzing proline production, wherein the exogenous polynucleotides are expressed in a manner so as to allow accumulation of the enzymes within a subcellular organelle of the plant. The invention further describes novel polynucleotides and nucleic acid constructs useful in implementing the methods and a transgenic plant resultant therefrom.
    Type: Application
    Filed: October 30, 2002
    Publication date: November 13, 2003
    Inventors: Hanan Stein, Aviah Zilberstein, Gadi Miller, Yoram Kapulnik