Patents by Inventor Hanfei HU

Hanfei HU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11958860
    Abstract: The present invention discloses a crystal form A of a compound, where the compound is S-(?)-2,3-methylenedioxy-5,8,13,13a-tetrahydro-10,11-dimethoxy-6H-dibenzo[a, g]quinolizine, and an X-ray powder diffraction pattern of the crystal form A includes three or more 2? values selected from the group consisting of: 12.21±0.2°, 13.381±0.2°, 15.181±0.2°, 16.171±0.2°, 17.101±0.2°, 19.801±0.2°, 21.511±0.2°, 24.391±0.2°, and 25.321±0.2°. The crystal form A of the compound of the present invention does not contain water and a solvent, has high stability and low hygroscopicity, and is suitable for patent medicine.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: April 16, 2024
    Assignee: Jiangsu Kanion Pharmaceutical Co., Ltd.
    Inventors: Wei Xiao, Wei Zhang, Yingguang Li, Qingming Guo, Shasha Gu, Hanfei Hu
  • Publication number: 20240043437
    Abstract: The present invention discloses a crystal form A of a compound, where the compound is S-(?)-2,3-methylenedioxy-5,8,13,13a-tetrahydro-10,11-dimethoxy-6H-dibenzo[a,g]quinolizine, and an X-ray powder diffraction pattern of the crystal form A includes three or more 2? values selected from the group consisting of: 12.21±0.2°, 13.381±0.2°, 15.181±0.2°, 16.171±0.2°, 17.101±0.2°, 19.801±0.2°, 21.511±0.2°, 24.391±0.2°, and 25.321±0.2°. The crystal form A of the compound of the present invention does not contain water and a solvent, has high stability and low hygroscopicity, and is suitable for patent medicine.
    Type: Application
    Filed: December 7, 2021
    Publication date: February 8, 2024
    Applicant: JIANGSU KANION PHARMACEUTICAL CO., LTD.
    Inventors: Wei XIAO, Wei ZHANG, Yingguang LI, Qingming GUO, Shasha GU, Hanfei HU
  • Patent number: 11564904
    Abstract: A Ginkgo diterpene lactone composition is provided. The extract can lower the neurological function score of a cerebral ischemia-reperfusion rat, reduce the cerebral ischemia area and the water content after brain tissue edema, improve SOD activity, and decrease the MDA content. The composition can inhibit rabbit platelet aggregation induced by PAF and ADP inducers at different time points so as to reduce the maximum aggregation rate. In addition, experiments show that the effect of each monomer compound in the Ginkgo diterpene lactone composition is significantly increased at certain proportion.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: January 31, 2023
    Assignee: JIANGSU KANION PHARMACEUTICAL CO., LTD.
    Inventors: Wei Xiao, Xiujuan Chang, Enli Zhou, Xiaodong Kang, Yongxiang Wang, Hanfei Hu, Yun Wu, Zhenzhong Wang, Chenfeng Zhang
  • Patent number: 11524041
    Abstract: A Ginkgo diterpene lactone composition is provided. The composition has the effect of improving a depressive state. The composition can prolong a tail flick interval time and a swimming interval time of a mouse to different degrees and can also increase the frequency of escaping from electric shock to different degrees. The additional addition of a certain amount of ginkgolide C, ginkgolide J, and ginkgolide L greatly enhances the effect of improving the depressive state. It is further proved through experiments that after the provision of the Ginkgo diterpene lactone composition, indexes, such as SOD, MDA, GSH, and TAC, can be improved to different degrees. For example, after the addition of a certain amount of ginkgolide C, ginkgolide J, and ginkgolide L, the improving effect gets more obvious, the oxidative stress level can be better improved, and the oxidative damage can be relieved.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: December 13, 2022
    Assignee: JIANGSU KANION PHARMACEUTICAL CO., LTD
    Inventors: Wei Xiao, Enli Zhou, Zeyu Cao, Xiujuan Chang, Xiaodong Kang, Yongxiang Wang, Hanfei Hu, Yun Wu, Zhenzhong Wang, Chenfeng Zhang
  • Publication number: 20210196773
    Abstract: A Ginkgo diterpene lactone composition is provided. The composition has the effect of improving a depressive state. The composition can prolong a tail flick interval time and a swimming interval time of a mouse to different degrees and can also increase the frequency of escaping from electric shock to different degrees. The additional addition of a certain amount of ginkgolide C, ginkgolide J, and ginkgolide L greatly enhances the effect of improving the depressive state. It is further proved through experiments that after the provision of the Ginkgo diterpene lactone composition, indexes, such as SOD, MDA, GSH, and TAC, can be improved to different degrees. For example, after the addition of a certain amount of ginkgolide C, ginkgolide J, and ginkgolide L, the improving effect gets more obvious, the oxidative stress level can be better improved, and the oxidative damage can be relieved.
    Type: Application
    Filed: November 13, 2018
    Publication date: July 1, 2021
    Inventors: Wei XIAO, Enli ZHOU, Zeyu CAO, Xiujuan CHANG, Xiaodong KANG, Yonxiang WANG, Hanfei HU, Yun WU, Zhenzhong WANG, Chenfeng ZHANG
  • Publication number: 20210069148
    Abstract: A Gingko diterpene lactone composition is provided. The extract can lower the neurological function score of a cerebral ischemia-reperfusion rat, reduce the cerebral ischemia area and the water content after brain tissue edema, improve SOD activity, and decrease the MDA content. The composition can inhibit rabbit platelet aggregation induced by PAF and ADP inducers at different time points so as to reduce the maximum aggregation rate. In addition, experiments show that the effect of each monomer compound in the Gingko diterpene lactone composition is significantly increased at certain proportion.
    Type: Application
    Filed: November 13, 2018
    Publication date: March 11, 2021
    Inventors: Wei XIAO, Xiujuan CHANG, Enli ZHOU, Xiaodong KANG, Yongxiang WANG, Hanfei HU, Yun WU, Zhenzhong WANG, Chenfeng ZHANG