Patents by Inventor Hang-Gyeong Chin

Hang-Gyeong Chin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11492667
    Abstract: Compositions, methods and kits are provided for identifying the presence and location of a target in chromosomal DNA. A nicking endonuclease fused to a binding domain that binds to a constant region of an antibody (NEFP) is provided that may be used for binding to a target directly or via an antibody that binds to the target. The target may be a protein or structural feature of the DNA and its presence and location may correspond to a phenotype and/or pathology in a biopsy or other cell sample for diagnostic purposes. The background is reduced by the addition of a glycoaminoglycan (GAG) that reversibly inhibits binding of the NEFP to DNA. Nick translation in the presence of a strand displacing polymerase enables the incorporation of tagged nucleotides that (i) blocks re-nicking; (ii) facilitates immobilization of DNA fragments around the target for sequencing; and/or (iii) enables dye labelling of the chromosomal DNA within the cell nuclei for analysis by microscopy.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: November 8, 2022
    Assignee: New England Biolabs, Inc.
    Inventors: Sriharsa Pradhan, Hang Gyeong Chin, George R. Feehery, Shuang-Yong Xu, Vishnu Udayakumaran Nair Sunitha Kumary, Julie Beaulieu, Pierre O. Esteve
  • Patent number: 11420977
    Abstract: The present invention is directed to compositions, methods and kits for treatment of cancer, e.g. heptacellular carcinoma (HCC). In some embodiments, the present invention discloses the use of a small-molecule compounds of Formula (I)-(V) to inhibit tubulin methylation or to modulate chromatin or cytoskeleton modification in a cell.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: August 23, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Scott Edward Schaus, Ulla Hansen, Hang Gyeong Chin
  • Publication number: 20220056537
    Abstract: Provided herein, among other things, are various compositions and methods for analyzing chromatin. In some embodiments, the composition may comprise a mixture of a nicking enzyme, four dNTPs, at least one labeled dNTP and, optionally, a polymerase. In some embodiments, this method may comprise: obtaining a sample comprising chromatin, reacting the sample with the composition to selectively label the open chromatin in the sample, and analyzing the labeled sample.
    Type: Application
    Filed: November 9, 2021
    Publication date: February 24, 2022
    Applicant: New England Biolabs, Inc.
    Inventors: Chaithanya Ponnaluri, Hang-Gyeong Chin, Pierre O. Esteve, Sriharsa Pradhan
  • Publication number: 20210388434
    Abstract: Compositions, methods and kits are provided for identifying the presence and location of a target in chromosomal DNA. A nicking endonuclease fused to a binding domain that binds to a constant region of an antibody (NEFP) is provided that may be used for binding to a target directly or via an antibody that binds to the target. The target may be a protein or structural feature of the DNA and its presence and location may correspond to a phenotype and/or pathology in a biopsy or other cell sample for diagnostic purposes. The background is reduced by the addition of a glycoaminoglycan (GAG) that reversibly inhibits binding of the NEFP to DNA. Nick translation in the presence of a strand displacing polymerase enables the incorporation of tagged nucleotides that (i) blocks re-nicking; (ii) facilitates immobilization of DNA fragments around the target for sequencing; and/or (iii) enables dye labelling of the chromosomal DNA within the cell nuclei for analysis by microscopy.
    Type: Application
    Filed: June 8, 2021
    Publication date: December 16, 2021
    Applicant: New England Biolabs, Inc.
    Inventors: Sriharsa Pradhan, Hang Gyeong Chin, George R. Feehery, Shuang-Yong Xu, Vishnu Udayakumaran Nair Sunitha Kumary, Julie Beaulieu, Pierre O. Esteve
  • Patent number: 11198910
    Abstract: Provided herein, among other things, are various compositions and methods for analyzing chromatin. In some embodiments, the composition may comprise a mixture of a nicking enzyme, four dNTPs, at least one labeled dNTP and, optionally, a polymerase. In some embodiments, this method may comprise: obtaining a sample comprising chromatin, reacting the sample with the composition to selectively label the open chromatin in the sample, and analyzing the labeled sample.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: December 14, 2021
    Assignee: New England Biolabs, Inc.
    Inventors: Chaithanya Ponnaluri, Hang-Gyeong Chin, Pierre O. Esteve, Sriharsa Pradhan
  • Publication number: 20200039996
    Abstract: The present invention is directed to compositions, methods and kits for treatment of cancer, e.g. hepatocellular carcinoma (HCC). In some embodiments, the present invention discloses the use of a small-molecule compounds of Formula (I)-(V) to inhibit tubulin methylation or to modulate chromatin or cytoskeleton modification in a cell.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: Trustees of Boston University
    Inventors: Scott Edward Schaus, Ulla Hansen, Hang Gyeong Chin
  • Publication number: 20190211404
    Abstract: Provided herein, among other things, are various compositions and methods for analyzing chromatin. In some embodiments, the composition may comprise a mixture of a nicking enzyme, four dNTPs, at least one labeled dNTP and, optionally, a polymerase. In some embodiments, this method may comprise: obtaining a sample comprising chromatin, reacting the sample with the composition to selectively label the open chromatin in the sample, and analyzing the labeled sample.
    Type: Application
    Filed: August 31, 2017
    Publication date: July 11, 2019
    Applicant: New England Biolabs, Inc.
    Inventors: Chaithanya Ponnaluri, Hang-Gyeong Chin, Pierre O. Esteve, Sriharsa Pradhan
  • Publication number: 20160046981
    Abstract: Nucleic acids comprising ?-glucosaminyloxy-5-methylcytosine; compositions, kits and methods of producing the nucleic acids using a glycosyltransferase; and methods of using the nucleic acids are described.
    Type: Application
    Filed: October 29, 2015
    Publication date: February 18, 2016
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Ivan R. Correa, JR., Nan Dai, Jurate Bitinaite, Sriharsa Pradhan, Hang-Gyeong Chin
  • Patent number: 9200260
    Abstract: Nucleic acids comprising ?-glucosaminyloxy-5-methylcytosine; compositions, kits and methods of producing the nucleic acids using a glycosyltransferase; and methods of using the nucleic acids are described.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 1, 2015
    Assignee: New England Biolabs, Inc.
    Inventors: Ivan R. Correa, Jr., Nan Dai, Jurate Bitinaite, Sriharsa Pradhan, Hang-Gyeong Chin
  • Publication number: 20150240310
    Abstract: Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs.
    Type: Application
    Filed: April 14, 2015
    Publication date: August 27, 2015
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Jurate Bitinaite, Romualdas Vaisvila, Sriharsa Pradhan, Yu Zheng, Richard J. Roberts, Hang-Gyeong Chin, Devora Cohen-Karni, Christopher Noren, Elisabeth A. Raleigh, Geoffrey Wilson
  • Patent number: 9034597
    Abstract: Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: May 19, 2015
    Assignee: New England Biolabs, Inc.
    Inventors: Jurate Bitinaite, Romualdas Vaisvila, Sriharsa Pradhan, Yu Zheng, Richard J. Roberts, Devora Cohen-Karni, Christopher Noren, Elisabeth A. Raleigh, Geoffrey Wilson, Hang-Gyeong Chin
  • Publication number: 20140127677
    Abstract: Nucleic acids comprising ?-glucosaminyloxy-5-methylcytosine; compositions, kits and methods of producing the nucleic acids using a glycosyltransferase; and methods of using the nucleic acids are described.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 8, 2014
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Ivan R. Correa, JR., Nan Dai, Jurate Bitinaite, Sriharsa Pradhan, Hang-Gyeong Chin
  • Publication number: 20120156677
    Abstract: Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs.
    Type: Application
    Filed: August 25, 2010
    Publication date: June 21, 2012
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Jurate Bitinaite, Romualdas Vaisvila, Sriharsa Pradhan, Yu Zheng, Richard J. Roberts, Devora Cohen-Karni, Christopher Noren, Elisabeth A. Raleigh, Geoffrey Wilson, Hang-Gyeong Chin