Patents by Inventor Hang-Ping Yao

Hang-Ping Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation and use of anti-MET-and-RON bispecific antibody and antibody-drug conjugate thereof
    Patent number: 11753477
    Abstract: Provided herein are a preparation method and use of an anti-MET-and-RON bispecific antibody and an antibody-drug conjugate thereof. The anti-MET-and-RON bispecific antibody includes an anti-MET antibody fragment and an anti-RON antibody fragment which are linked to each other through a specific chemical “knobs-into-holes” structure.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: September 12, 2023
    Assignee: PCM TARGETECH, LLC
    Inventors: Ming-Hai Wang, Hang-Ping Yao
  • Monoclonal antibodies specific to the plexin-semaphorin-integrin (PSI) domain of RON for drug delivery and its application in cancer therapy
    Patent number: 11208494
    Abstract: The present invention includes unique, isolated monoclonal antibodies that bind the PSI domain of human RON (RONPSI), and methods for making and using the same and novel combination therapies of anti-RONPSI antibodies, including humanized anti-RONPSI antibodies, nucleic acids that encode the heavy chain, the light chain, or both the light and heave chains of the antibody, host cells, expression vectors, and wherein the antibody or binding fragments thereof can be further conjugated with one or more cytotoxic or chemotherapeutic agents.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: December 28, 2021
    Assignee: PCM TARGETECH, LLC
    Inventors: Ming-Hai Wang, Hang-Ping Yao
  • PREPARATION AND USE OF ANTI-MET-AND-RON BISPECIFIC ANTIBODY AND ANTIBODY-DRUG CONJUGATE THEREOF
    Publication number: 20210395371
    Abstract: Provided herein are a preparation method and use of an anti-MET-and-RON bispecific antibody and an antibody-drug conjugate thereof. The anti-MET-and-RON bispecific antibody includes an anti-MET antibody fragment and an anti-RON antibody fragment which are linked to each other through a specific chemical “knobs-into-holes” structure.
    Type: Application
    Filed: February 10, 2021
    Publication date: December 23, 2021
    Inventors: Ming-Hai Wang, Hang-Ping Yao
  • MONOCLONAL ANTIBODIES SPECIFIC TO THE PLEXIN-SEMAPHORIN-INTEGRIN (PSI) DOMAIN OF RON FOR DRUG DELIVERY AND ITS APPLICATION IN CANCER THERAPY
    Publication number: 20190352422
    Abstract: The present invention includes unique, isolated monoclonal antibodies that bind the PSI domain of human RON (RONPSI), and methods for making and using the same and novel combination therapies of anti-RONPSI antibodies, including humanized anti-RONPSI antibodies, nucleic acids that encode the heavy chain, the light chain, or both the light and heave chains of the antibody, host cells, expression vectors, and wherein the antibody or binding fragments thereof can be further conjugated with one or more cytotoxic or chemotherapeutic agents.
    Type: Application
    Filed: August 1, 2019
    Publication date: November 21, 2019
    Inventors: Ming-Hai Wang, Hang-Ping Yao
  • Anti-Ron Monoclonal Antibodies as a Cytotoxic Drug Delivery System for Targeted Cancer Therapy
    Publication number: 20160311918
    Abstract: The present invention includes unique, isolated monoclonal antibodies that bind human RON, and methods for making and using the same.
    Type: Application
    Filed: December 15, 2014
    Publication date: October 27, 2016
    Inventors: Ming-Hai Wang, Hang-Ping Yao