Patents by Inventor Hangwen Li

Hangwen Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A LIPID
    Publication number: 20230263742
    Abstract: The invention provides a lipid of Formula (I) and nanoparticle compositions containing the same. Nanoparticle compositions including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 24, 2023
    Inventors: Yunsong CAI, Lei HUANG, Na LIU, Yu HANG, Weiguo YAO, Yujian ZHANG, Hangwen LI, Haifa SHEN
  • MODIFIED NUCLEOSIDE AND SYNTHESIS METHOD THEREFOR
    Publication number: 20230219994
    Abstract: A modified cytidine compound, that is, an aminooxy group is modified at the 4-position of a cytidine pyrimidine ring to produce derivative cytidine and nucleic acid containing the derivative cytidine, such as RNA. The expression level of the nucleic acid containing the modified cytidine, in particular mRNA, in the body is significantly improved.
    Type: Application
    Filed: August 4, 2020
    Publication date: July 13, 2023
    Inventors: Yunsong CAI, Hangwen Li, Lianxiao Liu, Ning Li
  • MODIFIED NUCLEOSIDE AND SYNTHETIC METHODS THEREOF
    Publication number: 20220135612
    Abstract: Disclosed are a modified cytidine compound, i.e. a new derivative cytidine generated by adding a guanidyl at position 4 of a cytidine, and a nucleic acid containing the modified compound, for example, RNA. The nucleic acid containing the modified cytidine, especially mRNA, can significantly increase the expression quantity of the mRNA in vivo.
    Type: Application
    Filed: February 12, 2020
    Publication date: May 5, 2022
    Inventors: Yunsong Cai, Hangwen Li, Lianxiao Liu, Ning Li