Abstract: The present invention relates to a compound represented by formula (I), or an isomer, isotope derivative, polymorph, prodrug thereof, or a pharmaceutically acceptable salt or solvate thereof: wherein R1, R2, R3a, R3b, R3c, R3d, W1, W2, G, Z and n are as described. The compound of formula I is a human cereblon (CRBN) E3 ubiquitin ligase inhibitor, which can be used for preparing PROTAC molecules. The CRBN E3 ubiquitin ligase inhibitor and PROTAC molecule can be used to treat cancer and other diseases.

Abstract: The present disclosure relates to a network operation and maintenance technology, and in particular to a system and method for generating network device driver files. One aspect of the present disclosure provides a system for generating network device driver files. The system includes: a network device capability model construction unit, configured to construct a capability model following a standard format on the basis of a capability set acquired from a network device; a driver function interface generation unit, configured to generate, based on the capability model, a driver function interface that can be called by an upper-layer application; and a control message generation unit, configured to receive configuration data from the upper-layer application via the generated driver function interface, and to generate, based on the configuration data, a control message for driving the network device.

Abstract: In communication applications, aggregate source image data at a transmitter exceeds the data that is needed to display a rendering of a viewport at a receiver. Improved streaming techniques that include estimating a location of a viewport at a future time. According to such techniques, the viewport may represent a portion of an image from a multi-directional video to be displayed at the future time, and tile(s) of the image may be identified in which the viewport is estimated to be located. In these techniques, the image data of tile(s) in which the viewport is estimated to be located may be requested at a first service tier, and the other tile in which the viewport is not estimated to be located may be requested at a second service tier, lower than the first service tier.

Abstract: A method for sample alignment is applied to a first participant system, where a first trusted execution environment is deployed at the first participant system. The method includes, in the first trusted execution environment, obtaining at least one first sample identifier of the first participant system; through the first trusted execution environment, obtaining at least one second sample identifier of the second participant system from the second trusted execution environment, where the second trusted execution environment is deployed at the second participant system; in the first trusted execution environment, determining the first initial intersection of the at least one first sample identifier and the at least one second sample identifier and performing the shuffle processing on all first target sample identifiers in the first initial intersection to obtain the first target intersection; and based on the first target intersection, determining the first sample alignment result.

Abstract: In communication applications, aggregate source image data at a transmitter exceeds the data that is needed to display a rendering of a viewport at a receiver. Improved streaming techniques that include estimating a location of a viewport at a future time. According to such techniques, the viewport may represent a portion of an image from a multi-directional video to be displayed at the future time, and tile(s) of the image may be identified in which the viewport is estimated to be located. In these techniques, the image data of tile(s) in which the viewport is estimated to be located may be requested at a first service tier, and the other tile in which the viewport is not estimated to be located may be requested at a second service tier, lower than the first service tier.

Abstract: The simulation device is provided with a user space and a network adapter. The method comprises: a simulation device obtains a serialization command of a simulation test and configures the serialization command for a plurality of MQTT client instances, controls the plurality of MQTT client instances to package the serialization command by using a simulation protocol stack of a user space so as to obtain a simulation message, transmits the simulation message to a network adapter, and the network adapter sends said message to an MQTT server for simulation testing.

Abstract: A data transmission method includes: determining, by a regional access device, a message that needs to be transmitted includes M pieces of QoS information; and after the regional access device determines that a device identifier in a first piece of QoS information is consistent with a device identifier of the regional access device, updating a QoS value of the message that needs to be transmitted with a first QoS value in the first piece of QoS information, and forwarding the updated message that needs to be transmitted. The first piece of QoS information is any one of the M pieces of QoS information.

Abstract: Embodiments of the present disclosure provide systems and methods for perspective shifting in a video conferencing session. In one exemplary method, a video stream may be generated. A foreground element may be identified in a frame of the video stream and distinguished from a background element of the frame. Data may be received representing a viewing condition at a terminal that will display the generated video stream. The frame of the video stream may be modified based on the received data to shift of the foreground element relative to the background element. The modified video stream may be displayed at the displaying terminal.

Abstract: Techniques are disclosed for coding video data predictively based on predictions made from spherical-domain projections of input pictures to be coded and reference pictures that are prediction candidates. Spherical projection of an input picture and the candidate reference pictures may be generated. Thereafter, a search may be conducted for a match between the spherical-domain representation of a pixel block to be coded and a spherical-domain representation of the reference picture. On a match, an offset may be determined between the spherical-domain representation of the pixel block to a matching portion of the of the reference picture in the spherical-domain representation. The spherical-domain offset may be transformed to a motion vector in a source-domain representation of the input picture, and the pixel block may be coded predictively with reference to a source-domain representation of the matching portion of the reference picture.

Abstract: In communication applications, aggregate source image data at a transmitter exceeds the data that is needed to display a rendering of a viewport at a receiver. Improved streaming techniques that include estimating a location of a viewport at a future time. According to such techniques, the viewport may represent a portion of an image from a multi-directional video to be displayed at the future time, and tile(s) of the image may be identified in which the viewport is estimated to be located. In these techniques, the image data of tile(s) in which the viewport is estimated to be located may be requested at a first service tier, and the other tile in which the viewport is not estimated to be located may be requested at a second service tier, lower than the first service tier.

Abstract: Methods of treating human papillomavirus (HPV)-induced conditions, HPV-induced lesions, or HPV-infected cells. The method involves administering one or more artemisinin-related compounds and one or more histone deacetylase (HDAC) inhibitors. In addition, treatment regimens involving the use of artemisinin-related compounds and HDAC inhibitors, and kits comprising pharmaceutical compositions of artemisinin-related compounds and HDAC inhibitors.

Abstract: In an example method, a system receives a plurality of frames of a video, and generates a data structure representing the video and representing a plurality of temporal layers. Generating the data structure includes: (i) determining a plurality of quality levels for presenting the video, where each of the quality levels corresponds to a different respective sampling period for sampling the frames of the video, (ii) assigning, based on the sampling periods, each of the frames to a respective one of the temporal layers of the data structure, and (iii) indicating, in the data structure, one or more relationships between (a) at least one the frames assigned to at least one of the temporal layers of the data structure, and (b) at least another one of the frames assigned to at least another one of the temporal layers of the data structure. Further, the system outputs the data structure.

Abstract: A data transmission method includes: determining, by a regional access device, a message that needs to be transmitted includes M pieces of QoS information; and after the regional access device determines that a device identifier in a first piece of QoS information is consistent with a device identifier of the regional access device, updating a QoS value of the message that needs to be transmitted with a first QoS value in the first piece of QoS information, and forwarding the updated message that needs to be transmitted. The first piece of QoS information is any one of the M pieces of QoS information.

Abstract: In communication applications, aggregate source image data at a transmitter exceeds the data that is needed to display a rendering of a viewport at a receiver. Improved streaming techniques that include estimating a location of a viewport at a future time. According to such techniques, the viewport may represent a portion of an image from a multi-directional video to be displayed at the future time, and tile(s) of the image may be identified in which the viewport is estimated to be located. In these techniques, the image data of tile(s) in which the viewport is estimated to be located may be requested at a first service tier, and the other tile in which the viewport is not estimated to be located may be requested at a second service tier, lower than the first service tier.

Abstract: In an example method, a system receives a plurality of frames of a video, and generates a data structure representing the video and representing a plurality of temporal layers. Generating the data structure includes: (i) determining a plurality of quality levels for presenting the video, where each of the quality levels corresponds to a different respective sampling period for sampling the frames of the video, (ii) assigning, based on the sampling periods, each of the frames to a respective one of the temporal layers of the data structure, and (iii) indicating, in the data structure, one or more relationships between (a) at least one the frames assigned to at least one of the temporal layers of the data structure, and (b) at least another one of the frames assigned to at least another one of the temporal layers of the data structure. Further, the system outputs the data structure.

Abstract: A forming method of a deep cavity thin-walled metal component with extremely small fillet radius is provided. In the forming method of a deep cavity thin-walled metal component with extremely small fillet radius, a global cavity is formed by deep drawing by means of a rigid die, an extremely small fillet is formed by means of a extrusion/pushing die, so that the deep drawing process is independent of the extremely small fillet forming process, and the problems of wrinkling, cracking and the like in the process of forming the two simultaneously are avoided. Thus, the problem that the extremely small fillet is difficult or impossible to form can be solved.

Abstract: The simulation device is provided with a user space and a network adapter. The method comprises: a simulation device obtains a serialization command of a simulation test and configures the serialization command for a plurality of MQTT client instances, controls the plurality of MQTT client instances to package the serialization command by using a simulation protocol stack of a user space so as to obtain a simulation message, transmits the simulation message to a network adapter, and the network adapter sends said message to an MQTT server for simulation testing.

Abstract: Techniques are disclosed for coding video data in which frames from a video source are partitioned into a plurality of tiles of common size, and the tiles are coded as a virtual video sequence according to motion-compensated prediction, each tile treated as having respective temporal location of the virtual video sequence. The coding scheme permits relative allocation of coding resources to tiles that are likely to have greater significance in a video coding session, which may lead to certain tiles that have low complexity or low motion content to be skipped during coding of the tiles for select source frames. Moreover, coding of the tiles may be ordered to achieve low coding latencies during a coding session.

Abstract: An ejector refrigeration cycle includes a compressor, a radiator, a branch portion, an ejector, a suction side decompressor, a windward evaporator, and a leeward evaporator. The ejector includes a nozzle portion and a pressure increasing portion. The windward evaporator and the leeward evaporator include at least one outflow side evaporation portion. The leeward evaporator includes a suction side evaporation portion. An outflow side evaporation temperature is a refrigerant evaporation temperature in the at least one outflow side evaporation portion of the leeward evaporator. A suction side evaporation temperature is a refrigerant evaporation temperature in the suction side evaporation portion of the leeward evaporator.

Abstract: When an ejector having a variable nozzle and a variable throttle mechanism are integrated together as an ejector module, a nozzle-side central axis CL1 and a decompression-side driving mechanism have a twisted positional relationship, if the nozzle-side central axis CL1 is defined as a central axis of a nozzle-side driving mechanism in a displacement direction in which the nozzle-side driving mechanism of the ejector having the variable nozzle displaces a needle valve, and the decompression-side central axis CL2 is defined as a central axis of a decompression-side driving mechanism in a displacement direction in which the decompression-side driving mechanism of the variable throttle mechanism displaces a throttle valve. When viewed from the central axis direction of one of the nozzle-side central axis CL1 and the decompression-side central axis CL2, a driving portion corresponding to the one central axis is disposed to overlap with the other central axis.