Abstract: Green bodies are safely, economically and efficiently debound in a dual quartz reactor by subjecting them to a steady laminar upward flow of freshly distilled solvent so that the concentration difference of soluble binder at the green body/solvent interface is at all times maximized for optimum binder extraction as per Fick's laws of diffusion. Binder extraction rate is monitored by inline spectrophotometry of the reactor overflow. Following solvent extraction, the residual insoluble binder is thermally extracted without the need to transfer the green bodies to a different vessel.

Abstract: A golf club head with center of gravity proximate to the club head's sweet spot is disclosed. The golf head is composed of a strike face component made from a high-density material and a club body component made from a lightweight material. This combination improves the golfer's chances to strike the golf ball with the club head sweet spot and to land the ball closer to the hole on the green.

Abstract: An acetabular reamer of the type used in total hip arthroplasty (THA) to prepare a patient's acetabulum for implantation of a hip prosthesis is described. The acetabular reamer consists of a substantially hemispherical cup having a plurality of cutter-hole combinations aligned along one or more loxodromes on the surface of the hemispherical cup. The reamer, complete with integral back plate for connecting the reamer to a driver, is produced to net shape using a molding and sinterwelding technique.

Abstract: The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

Abstract: The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibody that alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

Abstract: Structural inorganic cellular materials with controlled open porosity are produced by foaming fine particulate-laden aqueous solutions into stable, uniform, dodecahedral froth structures which are dried and sintered by microwave energy or high voltage instant electrical discharge. Porous open cell biomedical implants such as niobium or tantalum acetabular caps with engineered osteoconductive porosity are among the products achievable.

Abstract: A method of treating a mammal with an adiponectin mediated disorder comprising administering a therapeutically effective amount of an adiponectin variant with at least a 3-fold increased solubility relative to residues 110-244 of human adiponectin.

Abstract: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.

Abstract: The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibody that alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

Abstract: A composition comprising an adiponectin variant at a concentration of at least 2.0 mg/mL, and a pharmaceutically acceptable carrier, wherein less than 20% of said adiponectin variant would aggregate after storage at 4° C. for one week in 10 mM PO4, 150 mM NaCl buffer.

Abstract: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the adiponectin variant is not glycosylated, the adiponectin variant does not have residues 1-100 relative to human adiponectin, and wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.

Abstract: The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

Abstract: 1. A composition comprising an adiponectin variant at a concentration of at least 2.0 mg/mL, and a pharmaceutically acceptable carrier, wherein less than 20% of said adiponectin variant would aggregate after storage at 4° C. for one week in 10 mM PO4, 150 mM NaCl buffer.

Abstract: Gravitational sag and shape distortion by friction over supporting hardware during binder removal and sintering of green bodies made from sinterable particulate materials are overcome by processing in a supercritical fluid medium at a pressure whereby the density of the medium approaches or equals that of the green bodies.

Abstract: The disclosure describes an economical and environmentally benign method for using crystalline silicon metal kerf recovered from wiresaw slurries towards the fabrication of complex MEMS and MEMS components, including MEMS packages, with improved design features.

Abstract: The invention overcomes prior art problems associated with mass-production of technology-based commercial products like watch cases, mobile telephone housings, medical appliances, etc. such as high investment in tooling, delays in production, short economic tool life, inconsistence and mismatching between parts made in different geographical locations, etc., through the use of standardized, interchangeable ceramic mold inserts.

Abstract: The disclosure describes an economical and environmentally benign method to recover crystalline silicon metal kerf from wiresaw slurries and to shape and sinter said recovered crystalline silicon kerf into thin-layer PV cell configurations with enhanced surface texture for metallization and reduced optical reflection losses.

Abstract: Precise control of the shrinkage upon sintering of bodies made from mixtures of particulate materials and organic binders is achieved through precision pycnometry of the particulate materials and of the resulting sintered bodies, thus allowing a single molding tool to be used to produce parts in different sizes and from different materials and to tight manufacturing tolerances.

Abstract: A micro-electromagnetic device is formed by providing internal channels in a ceramic housing sintered from ceramic materials with high dielectric strength and infiltrating these channels with molten metal. The invention allows the fabrication of arrays of ceramic embedded micro-electromagnetic devices as well as ceramic embedded helical micro-antennas designed for use in the high GHz and THz regions at a fraction of the present cost of manufacturing of such devices and with virtually no restriction to their miniaturization.

Abstract: Rotors for stepping motors used in analog timepieces are produced from a mixture of prealloyed rare earth magnetic particles and a thermoplastic binder. The mixture is either tape cast in a magnetic field following blanking of green rotors or injection molded in a magnetic field. Following extraction of the binder the green parts are sintered to net shape. Improved magnetic properties, smaller dimensions, better tolerances and 100% material utilization are claimed.