Patents by Inventor Hanhan DU

Hanhan DU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED SOLUBLE T CELL RECEPTOR
    Publication number: 20230391846
    Abstract: The present invention provides an engineered chimeric soluble T cell receptor (ETCR), which comprises (i) all or part of TCR ? chain, fused to all or part of the antibody constant domain, and (ii) all or part of TCR ? chain, fused to all or part of the antibody constant domain. (i) and (ii) each comprise a designed linker, a designed binding interface between TCR and antibody domain and one or more mutagenesis in TCR domain to stabilize the ETCR thereof. Characterized in that the ETCR recognizes specific peptide-MHC (pMHC) complex and exhibits biological function.
    Type: Application
    Filed: October 29, 2021
    Publication date: December 7, 2023
    Inventors: Hanxiao YING, Man XU, Liying ZHANG, Hanhan DU, Juan LIU, Jijie GU, Gennady GOLOLOBOV, Zhisheng CHEN