Patents by Inventor Hani A. Awad

Hani A. Awad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230393118
    Abstract: In some embodiments, the invention provides tissue-on-a-chip and organ-on-a-chip devices with integrated, on-board photonic integrated circuit optical sensors that allow real-time detection of analytes released from cells disposed on either side of a porous, ultrathin membrane within the device. The invention further provides modular devices for studying cells and interactions between and among cell types. The devices and methods using them are useful for, among other thing, modeling the biological and physiological interactions of cells of different tissue types, allowing high-throughput screening of drug candidates, and informing safety and efficacy in a virtual clinical trial.
    Type: Application
    Filed: November 8, 2021
    Publication date: December 7, 2023
    Applicant: University of Rochester
    Inventors: John S. COGNETTI, Benjamin L. MILLER, Hani A. AWAD, Raquel E. AJALIK
  • Patent number: 8632797
    Abstract: Embodiments of surgical grafts, and methods, for the delivery of therapeutic agents to a target tissue via acellular matrices, are described. In some embodiments, nonviable matrices are successful in preventing or lessening adhesion formation by guiding tissue repair and remodeling, while also providing the target tissue with therapeutic agents that can act as repair and remodeling factors. An exemplary method to modulate flexor tendon healing and provide elimination or reduction of fibrotic adhesions involves loading a freeze-dried flexor digitorum longus allograft with recombinant adeno-associated viral (rAAV) vectors for the targeted and transient expression of growth/differentiation factor 5 (GDF5).
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: January 21, 2014
    Assignee: University of Rochester
    Inventors: Hani A. Awad, Edward M. Schwarz
  • Publication number: 20120093801
    Abstract: Embodiments of surgical grafts, and methods, for the delivery of therapeutic agents to a target tissue via acellular matrices, are described. In some embodiments, nonviable matrices are successful in preventing or lessening adhesion formation by guiding tissue repair and remodeling, while also providing the target tissue with therapeutic agents that can act as repair and remodeling factors. An exemplary method to modulate flexor tendon healing and provide elimination or reduction of fibrotic adhesions involves loading a freeze-dried flexor digitorum longus allograft with recombinant adeno-associated viral (rAAV) vectors for the targeted and transient expression of growth/differentiation factor 5 (GDF5).
    Type: Application
    Filed: October 31, 2007
    Publication date: April 19, 2012
    Applicant: Telefonakiebolaget L M Ericsson (publ)
    Inventors: Hani A. Awad, Edward M. Schwarz
  • Publication number: 20090227503
    Abstract: Methods of improving an outcome of a bone allograft procedure in a subject suffering from a massive bone defect are described, including providing a bone allograft to the subject and intermittently providing said subject with parathyroid hormone (PTH); where the PTH is provided in an amount effective to enhance in or adjacent to a bone allograft, relative to a patient not provided the PTH, at least one of callus bone volume, callus mineral content, callus bridging, graft stiffness, graft incorporation, and graft resistance to an applied torque.
    Type: Application
    Filed: February 9, 2009
    Publication date: September 10, 2009
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Hani A. Awad, Edward M. Schwarz, Susan Bukata, J. Edward Puzas, Regis J. O'Keefe, Randy Rosier