Patents by Inventor Hani N. Sabbah
Hani N. Sabbah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20160338831Abstract: Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. Specific cardiac conditions treatable by these systems and methods include, for example, dilated cardiomyopathy (with or without overt aneurismal formations), congestive heart failure, and ventricular arrhythmias.Type: ApplicationFiled: May 22, 2016Publication date: November 24, 2016Inventors: Hani N. Sabbah, Randall J. Lee, Andrew G. Hinson
-
Patent number: 9440080Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.Type: GrantFiled: March 9, 2015Date of Patent: September 13, 2016Assignee: Impulse Dynamics NVInventors: Benny Rousso, Yuval Mika, Shlomo Ben-Haim, Hani N. Sabbah
-
Patent number: 9375313Abstract: Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. These techniques may also be used to treat localized conditions, whether or not they have progressed to cardiomyopathy.Type: GrantFiled: September 7, 2007Date of Patent: June 28, 2016Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, HEARTFORD HEALTH SYSTEM, CARDIOPOLYMERS, INC.Inventors: Hani N. Sabbah, Randall J. Lee, Andrew G. Hinson
-
Publication number: 20150313933Abstract: A method for treating diastolic heart failure is provided including identifying a subject having diastolic heart failure and administering a therapeutically effective amount of a galectin-3 inhibitor to the subject to at least partially alleviate a symptom of diastolic heart failure.Type: ApplicationFiled: December 20, 2013Publication date: November 5, 2015Inventor: Hani N. Sabbah
-
Publication number: 20150246092Abstract: The disclosure provides methods of preventing or treating heart failure in a mammalian subject, reducing risk factors associated with heart failure, and/or reducing the likelihood or severity of heart failure. The disclosure also provides methods of preventing, or treating LV remodeling in a mammalian subject, and/or reducing the likelihood or severity of LV remodeling. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide. In some embodiments, the methods comprise administering to the subject an effective amount of an aromatic cationic peptide to reduce levels of C-reactive protein, tumor necrosis factor alpha, interleukin 6, reactive oxygen species, Nt-pro BNP, and/or cardiac troponin I, and/or reduce expression levels of MLCL AT1 and/or ALCAT 1 in subjects in need thereof.Type: ApplicationFiled: October 22, 2013Publication date: September 3, 2015Inventors: D. Travis Wilson, Hani N. Sabbah
-
Publication number: 20150174404Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.Type: ApplicationFiled: March 9, 2015Publication date: June 25, 2015Inventors: Benny ROUSSO, Yuval MIKA, Shlomo BEN-HAIM, Hani N. SABBAH
-
Patent number: 8977353Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.Type: GrantFiled: August 20, 2013Date of Patent: March 10, 2015Assignee: Impulse Dynamics NVInventors: Benny Rousso, Yuval Mika, Shlomo Ben-Haim, Hani N. Sabbah
-
Publication number: 20140330249Abstract: An injector for delivering an injectate into the myocardium of the heart may be implemented as a catheter or a handheld unit. The injector includes a body, a stabilizer secured to a distal end of the body, and a needle that may be controllably advanced from the distal end of the body. The stabilizer stabilizes the distal end of the body relative to the myocardium while the heart beats. An enlarged region disposed along the needle prevents the needle from being advanced into the myocardium beyond a desired penetration depth. To make an injection, the physician brings the distal end of the body in proximity to the myocardium, actuates the stabilizer to stabilize the distal end relative to the myocardium, and advances the needle into the myocardium. Advancement of the needle is impeded by the enlarged region, thereby placing the needle tip at the desired penetration depth for the injection.Type: ApplicationFiled: July 17, 2014Publication date: November 6, 2014Applicant: HENRY FORD HEALTH SYSTEMInventor: Hani N. Sabbah
-
Patent number: 8801665Abstract: An injector for delivering an injectate into the myocardium of the heart may be implemented as a catheter or a handheld unit. The injector includes a body, a stabilizer secured to a distal end of the body, and a needle that may be controllably advanced from the distal end of the body. The stabilizer stabilizes the distal end of the body relative to the myocardium while the heart beats. An enlarged region disposed along the needle prevents the needle from being advanced into the myocardium beyond a desired penetration depth. To make an injection, the physician brings the distal end of the body in proximity to the myocardium, actuates the stabilizer to stabilize the distal end relative to the myocardium, and advances the needle into the myocardium. Advancement of the needle is impeded by the enlarged region, thereby placing the needle tip at the desired penetration depth for the injection.Type: GrantFiled: April 9, 2009Date of Patent: August 12, 2014Assignee: Henry Ford Health SystemInventor: Hani N. Sabbah
-
Publication number: 20130338425Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.Type: ApplicationFiled: August 20, 2013Publication date: December 19, 2013Applicant: Impulse Dynamics NVInventors: Benny ROUSSO, Yuval MIKA, Shlomo BEN-HAIM, Hani N. SABBAH
-
Patent number: 8548583Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.Type: GrantFiled: May 4, 2006Date of Patent: October 1, 2013Assignee: Impulse Dynamics NVInventors: Benny Rousso, Yuval Mika, Shlomo Ben-Haim, Hani N. Sabbah
-
Publication number: 20130211182Abstract: Cardiomyopathy may be treated by distributing a space-occupying diastole-assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve.Type: ApplicationFiled: January 15, 2013Publication date: August 15, 2013Inventors: Hani N. Sabbah, Randall J. Lee, Andrew G. Hinson
-
Patent number: 8419711Abstract: Structurally supportive material is implanted or injected into cardiac veins as discrete masses at various sites in the cardiac venous system to reinforce the myocardium for the purpose of preventing, moderating, stopping or reversing negative cardiac remodeling due to various adverse cardiac conditions, both acute and chronic, or for the purpose of treating localize anomalies of the heart, or for both purposes. The sites may be arranged in a pattern about one or more chambers of the heart such that the masses cooperatively reduce stress in the chamber wall and reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function.Type: GrantFiled: December 17, 2010Date of Patent: April 16, 2013Assignee: Henry Ford Health SystemInventor: Hani N. Sabbah
-
Patent number: 8352031Abstract: A method of treating a cardiac arrhythmia, comprising: determining a desired arrhythmia control; selecting an electric field having an expected effect of modifying protein activity of at least one protein as a response of a cardiac tissue to the field, said expected effect correlated with said desired arrhythmia control; and applying said field to said cardiac tissue.Type: GrantFiled: May 24, 2007Date of Patent: January 8, 2013Assignee: Impulse Dynamics NVInventors: Benny Rousso, Hani N. Sabbah
-
Patent number: 8326416Abstract: Method and apparatus for modifying gene expression in cardiac muscle cells, by the application of electric fields. In some embodiments, the modification provides treatment of heart failure. Optionally, the treatment also provides an immediate improvement in cardiac function.Type: GrantFiled: October 25, 2010Date of Patent: December 4, 2012Assignee: Impulse Dynamics NVInventors: Yuval Mika, Hani N. Sabbah, Walid Haddad, Benny Rousso
-
Publication number: 20110166412Abstract: A cardiac support device including a jacket and elastic attachment structure for self-securing the jacket to a heart. The attachment structures can include undulating metal and polymer elements, a silicone band and elastomeric filaments on a base end of the jacket.Type: ApplicationFiled: March 15, 2011Publication date: July 7, 2011Applicant: MARDIL, INC.Inventors: Robert G. WALSH, Aaron J. HJELLE, Paul Andrew PIGNATO, Ann Margaret THOMAS, Hani N. SABBAH, Noreen Walen THOMPSON, Holly J. HICKS
-
Publication number: 20110105397Abstract: The present invention relates to novel methods of treating heart failure comprising administering an amount of stresscopin-like peptide to a subject in need thereof; and substantially maintaining the amount of said peptide present in the plasma of said subject at a concentration resulting in a therapeutic benefit without a substantial increase in the heart rate of said subject. The method involves the use of stresscopin-like peptides that are selective corticotrophin releasing hormone receptor type 2 (CRHR2) agonists.Type: ApplicationFiled: November 4, 2010Publication date: May 5, 2011Inventors: Peter J. Gengo, Hani N. Sabbah, Nigel P. Shankley
-
Publication number: 20110093028Abstract: The description above should not be construed as limiting the scope of the invention to the specific embodiments described, which are provided merely as examples or illustrations. The scope of the invention encompasses interchangeable substitutions that are known to or would be appreciated by those skilled in the art. Many other variations are possible. Thus, the scope of the invention should be determined by the appended claims and their legal equivalents, rather than by only the examples given above.Type: ApplicationFiled: October 25, 2010Publication date: April 21, 2011Applicant: Impulse Dynamics NVInventors: Yuval Mika, Hani N. Sabbah, Walid Haddad, Benny Rousso
-
Publication number: 20110087190Abstract: Structurally supportive material is implanted or injected into cardiac veins as discrete masses at various sites in the cardiac venous system to reinforce the myocardium for the purpose of preventing, moderating, stopping or reversing negative cardiac remodeling due to various adverse cardiac conditions, both acute and chronic, or for the purpose of treating localize anomalies of the heart, or for both purposes. The sites may be arranged in a pattern about one or more chambers of the heart such that the masses cooperatively reduce stress in the chamber wall and reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function.Type: ApplicationFiled: December 17, 2010Publication date: April 14, 2011Applicant: HENRY FORD HEALTH SYSTEMInventor: Hani N. Sabbah
-
Patent number: 7875017Abstract: Structurally supportive material is implanted or injected into cardiac veins as discrete masses at various sites in the cardiac venous system to reinforce the myocardium for the purpose of preventing, moderating, stopping or reversing negative cardiac remodeling due to various adverse cardiac conditions, both acute and chronic, or for the purpose of treating localize anomalies of the heart, or for both purposes. The sites may be arranged in a pattern about one or more chambers of the heart such that the masses cooperatively reduce stress in the chamber wall and reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function.Type: GrantFiled: April 10, 2008Date of Patent: January 25, 2011Assignee: Henry Ford Health SystemInventor: Hani N. Sabbah