Abstract: Modular prosthetic valves are disclosed that may support a customized number of leaflets. e.g., four or more leaflets carried by a support structure, such as a frame or stent, which may be used to replace diseased mitral, aortic, tricuspid, or pulmonary valves.

Abstract: Adaptive graft assemblies and methods of manufacture and implantation are provided herein. In particular, such grafts can be 3D printed and can be defined as standard designs or patient-specific, external sheaths customized for specific vein graft dimensions following minimally/non-invasive vein mapping and computational modeling. The external sheath may include one or more layers of various biomaterials to produce customized biomechanical properties. The external sheath may be made to elute specific bioactive drugs allowing for pharmacologic prevention of adverse remodeling in addition to mechanical support. These customizable features may be tailored for each patient individually depending on specific medical history, including hypertension, diabetes, smoking history, anatomy or any pertinent patient attribute.

Abstract: Engineered multilevel cell sheet-derived blood vessels and methods of preparing and using them are disclosed. Blood vessels are generated by wrapping cell sheets around a rod-like device, such as an angiocath needle, to form a tube, which is stabilized with a cyanoacrylate membrane or fibrin glue followed by endothelialization. Such engineered blood vessels can be implanted in tissue and used in vascular surgery as vascular bypass or interposition grafts as well as for vascularization and perfusion of tissue or organs prior to transplant.