Abstract: The present invention discloses a novel switchable dual chimeric antigen receptor-T (sdCAR-T) cell and a construction method and use thereof, which fall within the field of cellular immunotherapy for tumors. The dual chimeric antigen receptor consists of a first chimeric antigen receptor for MSLN and a second chimeric antigen receptor for FITC. A dual-targeted functional T cells regulated by specific exogenous bifunctional molecules is constructed, and the exogenous molecules are used to preliminarily discuss the in vivo and in vitro activity of the dual chimeric antigen receptor-T cell. By means of in vitro and in vivo tests, it is confirmed that the activation mode of the constructed CAR-T cell is controlled by the combination of endogenous tumor antigens and exogenous bifunctional molecules, and this combined regulation mode can significantly improve the safe application of CAR-T cell immunotherapy.

Abstract: A framework for object registration, and in particular for registering and executing calculation models and business rules, is described herein. In one embodiment, metadata definitions and input/output Application Program Interfaces (APIs) define uniform conventions that, when followed by a customized calculation model or business rule, allow transparent execution of pre-defined as well as customized calculation models and business rules. In one embodiment, a customized calculation model is registered with a stored procedure and a metadata table. In another embodiment, business rules are registered with a stored procedure and type information. By following the uniform conventions, initial processing is enabled with pre-defined calculation models or business rules, while subsequent processing is seamlessly enabled with customized calculation models or business rules.

Abstract: The present application provides an electric lock device, adopting a clutch mechanism composed of a driven gear and a turntable. The first side of the driven gear is provided with a mounting position for the turntable to be embedded, the sidewall of the mounting position is provided with an arc-shaped recess, and the outer sidewall of the turntable is provided with an arc-shaped bump corresponding to the arc-shaped recess. The central angle corresponding to the arc-shaped recess is denoted as ?, and the central angle corresponding to the arc-shaped bump is denoted as ?, then ? and ? satisfy: ????180°. Based on the above structure, there is a rotation virtual position greater than or equal to 180° between the driven gear and the turntable, that is, the gear can be rotated at least 180° regardless of the angle to which the gear rotates the turntable.

Abstract: The present application provides an electric lock device, adopting a clutch mechanism composed of a driven gear and a turntable. The first side of the driven gear is provided with a mounting position for the turntable to be embedded, the sidewall of the mounting position is provided with an arc-shaped recess, and the outer sidewall of the turntable is provided with an arc-shaped bump corresponding to the arc-shaped recess. The central angle corresponding to the arc-shaped recess is denoted as ?, and the central angle corresponding to the arc-shaped bump is denoted as ?, then ? and ? satisfy: ????180°. Based on the above structure, there is a rotation virtual position greater than or equal to 180° between the driven gear and the turntable, that is, the gear can be rotated at least 180° regardless of the angle to which the gear rotates the turntable.

Abstract: A data flow model format allows for improved data flow model creation and execution. The data flow models can provide a user with greater flexibility in selecting an appropriate data flow model, including providing information about the data flow model and selecting from multiple available data flow models. Tabular or graphical visualizations can aid the user in understanding a data flow model and retrieving desired information. Technical features such as designing a data flow with a single data output, and maintaining node identifiers in node metadata, can reduce coupling between software components and improve security and performance.

Abstract: A data flow model format allows for improved data flow model creation and execution. The data flow models can provide a user with greater flexibility in selecting an appropriate data flow model, including providing information about the data flow model and selecting from multiple available data flow models. Tabular or graphical visualizations can aid the user in understanding a data flow model and retrieving desired information. Technical features such as designing a data flow with a single data output, and maintaining node identifiers in node metadata, can reduce coupling between software components and improve security and performance.

Abstract: A framework for object registration, and in particular for registering and executing calculation models and business rules, is described herein. In one embodiment, metadata definitions and input/output Application Program Interfaces (APIs) define uniform conventions that, when followed by a customized calculation model or business rule, allow transparent execution of pre-defined as well as customized calculation models and business rules. In one embodiment, a customized calculation model is registered with a stored procedure and a metadata table. In another embodiment, business rules are registered with a stored procedure and type information. By following the uniform conventions, initial processing is enabled with pre-defined calculation models or business rules, while subsequent processing is seamlessly enabled with customized calculation models or business rules.