Patents by Inventor Hanna Niezna?ska

Hanna Niezna?ska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prion protein-dendrimer conjugates for use in treatment of alzheimer disease
    Patent number: 10815292
    Abstract: The present invention relates to PrP-derived peptide fragments with SEQ ID NO: 1 or SEQ ID NO: 2 or SEQ ID NO: 3 or SEQ ID NO: 4 for use as a medicament in the treatment of A? amyloidogenesis-related pathologies and/or A?-related toxicity, in particular of Alzheimer disease (AD), to a conjugate comprising PrP-derived peptide fragments with SEQ ID NO: 1 or SEQ ID NO: 3 and/or SEQ ID NO: 2 or SEQ ID NO: 4 and a carrier molecule, wherein the carrier molecule is a pharmacologically admissible molecule, preferably a low-generation dendrimer such as PAMAM dendrimer, and a method of manufacturing the above conjugate.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: October 27, 2020
    Assignees: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akadamii Nauk, Case Western Reserve University
    Inventors: Krzysztof Nieznański, Hanna Nieznańska, Witold K. Surewicz, Krystyna Surewicz, Magdalena Bandyszewska