Patents by Inventor Hanna Rapaport
Hanna Rapaport has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230130132Abstract: Pharmaceutical compositions comprising amphiphilic peptides are provided. The pharmaceutical compositions are useful in treating or preventing various orthopedic and dental-related infectious and/or inflammatory conditions.Type: ApplicationFiled: March 24, 2021Publication date: April 27, 2023Inventors: Oron Zeevi-Yacoby, Hanna Rapaport, Noa Harduf, Dganit Shkedy, Hodaya Green
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Patent number: 10799462Abstract: Provided are co-assembled nanoparticles including at least one polypeptide including a polyanion; and at least one amphiphilic peptide capable of forming a ?-sheet structure, a derivative or a salt thereof, the amphiphilic peptide including at least 2 pairs of alternating hydrophobic/hydrophilic amino acid residues in which the hydrophilic amino acid residue is positively charged, and methods of preparation of the nanoparticles. Further provided are pharmaceutical compositions including the co-assembled nanoparticles and a pharmaceutically active ingredient, dissolved, entrapped, encapsulated or attached to the co-assembled nanoparticles. Further provided are therapeutic uses of the pharmaceutical compositions.Type: GrantFiled: May 13, 2015Date of Patent: October 13, 2020Assignee: B. G. Negev Technologies and Applications Ltd., at Ben-Gurion UniversityInventors: Hanna Rapaport, Ifat Cohen
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Patent number: 10213527Abstract: An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.Type: GrantFiled: August 3, 2017Date of Patent: February 26, 2019Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Hanna Rapaport, Anna Gittelman
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Publication number: 20170328895Abstract: An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.Type: ApplicationFiled: August 3, 2017Publication date: November 16, 2017Applicant: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Hanna RAPAPORT, Anna GITTELMAN
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Publication number: 20170258735Abstract: Provided are co-assembled nanoparticles including at least one polypeptide including a polyanion; and at least one amphiphilic peptide capable of forming a ?-sheet structure, a derivative or a salt thereof, the amphiphilic peptide including at least 2 pairs of alternating hydrophobic/hydrophilic amino acid residues in which the hydrophilic amino acid residue is positively charged, and methods of preparation of the nanoparticles. Further provided are pharmaceutical compositions including the co-assembled nanoparticles and a pharmaceutically active ingredient, dissolved, entrapped, encapsulated or attached to the co-assembled nanoparticles. Further provided are therapeutic uses of the pharmaceutical compositions.Type: ApplicationFiled: May 13, 2015Publication date: September 14, 2017Applicant: B. G. Negev Technologies and Applications Ltd., at Ben-Gurion UniversityInventors: Hanna RAPAPORT, Ifat COHEN
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Patent number: 9731048Abstract: An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.Type: GrantFiled: June 3, 2013Date of Patent: August 15, 2017Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventors: Hanna Rapaport, Anna Gittelman
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Patent number: 9670249Abstract: The present invention relates in general to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in vitro and in situ biomineralization and inducing bone repair. The present invention provides peptides, which are useful in hydrogels and other pharmaceutical compositions, and methods and kits of use for bone repair and promotion of biomineralization. Certain hydrogels according to the invention comprise cells within or adhered to the peptide matrix.Type: GrantFiled: January 14, 2014Date of Patent: June 6, 2017Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventor: Hanna Rapaport
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Publication number: 20170014473Abstract: The present invention provides methods for prevention, prevention of progression, and treatment of osteoporosis and pre-osteoporotic conditions comprising direct administering to osteoporotic bone of a composition comprising amphiphilic peptides and peptide matrices thereof, useful in promoting biomineralization, local osteoporotic medications and inducing bone repair.Type: ApplicationFiled: September 29, 2016Publication date: January 19, 2017Inventor: Hanna RAPAPORT
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Patent number: 9457056Abstract: The present invention provides methods for prevention, prevention of progression, and treatment of osteoporosis and pre-osteoporotic conditions comprising direct administering to osteoporetic bone of a composition comprising amphiphilic peptides and peptide matrices thereof, useful in promoting biomineralization, local osteoporetic medications and inducing bone repair.Type: GrantFiled: December 3, 2008Date of Patent: October 4, 2016Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventor: Hanna Rapaport
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Publication number: 20150119334Abstract: An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.Type: ApplicationFiled: June 3, 2013Publication date: April 30, 2015Applicant: Ben-Gurion niversity of the Negev Research and Development AuthorityInventors: Hanna Rapaport, Anna Gittelman
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Publication number: 20140219981Abstract: The present invention relates in general to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in vitro and in situ biomineralization and inducing bone repair. The present invention provides peptides, which are useful in hydrogels and other pharmaceutical compositions, and methods and kits of use for bone repair and promotion of biomineralization. Certain hydrogels according to the invention comprise cells within or adhered to the peptide matrix.Type: ApplicationFiled: January 14, 2014Publication date: August 7, 2014Applicant: Ben-Gurion University of the Negev Research and Development AuthorityInventor: Hanna RAPAPORT
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Patent number: 8658763Abstract: The present invention relates to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in vitro and in situ biomineralization and inducing bone repair. The present invention provides peptides, which are useful in hydrogels and other pharmaceutical compositions, and methods and kits of use for bone repair and promotion of biomineralization. Certain hydrogels according to the invention comprise cells within or adhered to the peptide matrix.Type: GrantFiled: June 19, 2007Date of Patent: February 25, 2014Assignee: Ben-Gurion University of the Negev Research and Development AuthorityInventor: Hanna Rapaport
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Publication number: 20100297096Abstract: The present invention provides methods for prevention, prevention of progression, and treatment of osteoporosis and pre-osteoporotic conditions comprising direct administering to osteoporetic bone of a composition comprising amphiphilic peptides and peptide matrices thereof, useful in promoting biomineralization, local osteoporetic medications and inducing bone repair.Type: ApplicationFiled: December 3, 2008Publication date: November 25, 2010Inventor: Hanna Rapaport
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Publication number: 20100015197Abstract: The present invention relates to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in vitro and in situ biomineralization and inducing bone repair. The present invention provides peptides, which are useful in hydrogels and other pharmaceutical compositions, and methods and kits of use for bone repair and promotion of biomineralization. Certain hydrogels according to the invention comprise cells within or adhered to the peptide matrix.Type: ApplicationFiled: June 19, 2007Publication date: January 21, 2010Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEInventor: Hanna Rapaport