Patents by Inventor Hanna Stina Dreja

Hanna Stina Dreja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Latent fusion protein
    Patent number: 7307147
    Abstract: The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent biological agents. The method comprises associating a fusion protein comprising a latency associated peptide and a proteolytic cleavage site with a pharmaceutically active agent. The fusion protein also has application in providing site specific activation to a latent pharmaceutically active agent.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: December 11, 2007
    Assignee: Queen Mary and Westfield College
    Inventors: Yuti Chernajovsky, Hanna Stina Dreja, Gillian Adams
  • Latent fusion protein
    Patent number: 7141392
    Abstract: The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent biological agents. The method comprises associating a fusion protein comprising a latency associated peptide and a proteolytic cleavage site with a pharmaceutically active agent. The fusion protein also has application in providing site specific activation to a latent pharmaceutically active agent.
    Type: Grant
    Filed: January 7, 2004
    Date of Patent: November 28, 2006
    Assignee: Queen Mary and Westfield College
    Inventors: Yuti Chernajovsky, Hanna Stina Dreja, Gillian Adams
  • Latent fusion protein
    Patent number: 6942853
    Abstract: This invention provides a nucleic acid construct comprising a first nucleic acid sequence encoding a pharmaceutically active agent and a second nucleotide sequence encoding a latency associated peptide, in which a nucleic acid sequence encoding a proteolytic cleavage site is provided between the first and second nucleic acid sequences. The invention further provides a fusion protein comprising a latency associated peptide and a proteolytic cleavage site wherein the fusion protein is associated with a pharmaceutically active agent. Also disclosed are processes for preparing the construct and fusion protein, methods of treatment using the construct and fusion protein and pharmaceutical compositions containing the construct and fusion protein.
    Type: Grant
    Filed: January 9, 2001
    Date of Patent: September 13, 2005
    Assignee: Queen Mary and Westfield College
    Inventors: Yuti Chernajovsky, Hanna Stina Dreja, Gillian Adams
  • Latent fusion protein
    Publication number: 20040147444
    Abstract: The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent biological agents. The method comprises associating a fusion protein comprising a latency associated peptide and a proteolytic cleavage site with a pharmaceutically active agent. The fusion protein also has application in providing site specific activation to a latent pharmaceutically active agent.
    Type: Application
    Filed: January 7, 2004
    Publication date: July 29, 2004
    Inventors: Yuti Chernajovsky, Hanna Stina Dreja, Gillian Adams
  • Latent fusion protein
    Publication number: 20020151478
    Abstract: This invention provides a nucleic acid construct comprising a first nucleic acid sequence encoding a pharmaceutically active agent and a second nucleotide sequence encoding a latency associated peptide, in which a nucleic acid sequence encoding a proteolytic cleavage site is provided between the first and second nucleic acid sequences. The invention further provides a fusion protein comprising a latency associated peptide and a proteolytic cleavage site wherein the fusion protein is associated with a pharmaceutically active agent. Also disclosed are processes for preparing the construct and fusion protein, methods of treatment using the construct and fusion protein and pharmaceutical compositions containing the construct and fusion protein.
    Type: Application
    Filed: January 9, 2001
    Publication date: October 17, 2002
    Inventors: Yuti Chernajovsky, Hanna Stina Dreja, Gillian Adams