Patents by Inventor Hannah J. Gould

Hannah J. Gould has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IgE antagonists
    Patent number: 5962634
    Abstract: The present invention relates to methods for modulating interaction between IgE and Fc.epsilon.R1. The present invention also relates to compounds that modulate IgE binding to Fc.epsilon.R1.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: October 5, 1999
    Assignees: Thomas Jefferson University, King's College
    Inventors: Bradford A. Jameson, Brian J. Sutton, James M. McDonnell, Hannah J. Gould, Robert Korngold, Andrew J. Beavil
  • Polypeptide competitor for immunoglobulin E
    Patent number: 5180805
    Abstract: A competitor for human Immunoglobulin E (IgE) comprises a polypeptide which has a core sequence of seventy-six amino acids which is shown, together with the corresponding DNA sequence coding therefor, in FIG. 2. This amino acid sequence, numbered 1 to 76, corresponds to amino acids 301 to 376 of the epsilon heavy cain of IgE. The polypeptide may also include additional short sequences at the beginning and/or end of the core sequence which are physiologically harmless and do not contribute to the ability of the core sequence to bind compete with native IgE for the high-affinity receptor sites on human cells. The polypeptide is indicated for the treatment of Type I hypersensitivity reactions such as hay fever. The polypeptide may be produced synthetically or by expression from Escherichia coli containing a plasmid having a DNA segment coding for the polypeptide.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: January 19, 1993
    Assignee: Research Corporation Limited
    Inventors: Hannah J. Gould, Birgit A. Helm