Patents by Inventor Hanne Bentz

Hanne Bentz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Collagen-polymer conjugates
    Patent number: 5162430
    Abstract: Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
    Type: Grant
    Filed: November 14, 1989
    Date of Patent: November 10, 1992
    Assignee: Collagen Corporation
    Inventors: Woonza Rhee, Donald G. Wallace, Alan S. Michaels, Ramon A. Burns, Jr., Louis Fries, Frank DeLustro, Hanne Bentz
  • Method of treating inflammation
    Patent number: 5008240
    Abstract: Inflammation, acute and/or chronic, is treated with a CIF (TGF-.beta.). The CIF may be administered locally or systemically, depending upon the indication, and does not require coadministration or activator or cofactor for efficacy.
    Type: Grant
    Filed: August 9, 1988
    Date of Patent: April 16, 1991
    Assignee: Collagen Corporation
    Inventors: Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Inductive collagen-based bone repair preparations
    Patent number: 5001169
    Abstract: A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with a carrier having a percentage of mineral carrier. The resulting implants are sufficiently hypoimmunogenic to be effective when implanted in xenogeneic hosts.
    Type: Grant
    Filed: January 6, 1986
    Date of Patent: March 19, 1991
    Assignee: Collagen Corporation
    Inventors: Ranga Nathan, Saeid Seyedin, Karl Piez, Hanne Bentz
  • Method of treating inflammation with cartilage inducing factor
    Patent number: 4971952
    Abstract: Inflammation, acute and/or chronic, is treated with a CIF (TGF-beta). The CIF may be administered locally or systemically, depending upon the indication, and does not require coadministration of activator or cofactor for efficacy.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: November 20, 1990
    Assignee: Collagen Corporation
    Inventors: Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Polypeptide cartilage-inducing factors found in bone
    Patent number: 4843063
    Abstract: Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to hmogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: June 8, 1988
    Date of Patent: June 27, 1989
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Polypeptide cartilage-inducing factors found in bone
    Patent number: 4810691
    Abstract: Two proteins that are found is bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: March 7, 1989
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Method of treating inflammation
    Patent number: 4806523
    Abstract: Inflammation, acute and/or chronic, is treated with a CIF (TGF-.beta.). The CIF may be administered locally or symstemically, depending upon the indication, and does not require coadministraion of activator or cofactor for efficacy.
    Type: Grant
    Filed: March 6, 1986
    Date of Patent: February 21, 1989
    Assignee: Collagen Corporation
    Inventors: Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Polypeptide cartilage-inducing factors found in bone
    Patent number: 4774322
    Abstract: Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: September 27, 1988
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Polypeptide cartilage-inducing factors found in bone used in tissue proliferation
    Patent number: 4774228
    Abstract: Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: September 27, 1988
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Inductive collagen based bone repair preparations
    Patent number: 4563350
    Abstract: A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with an carrier having a percentage of non-fibrillar collagen. The resulting implants are sufficiently hypo-immunogenic to be effective when implanted in xenogeneic hosts.
    Type: Grant
    Filed: October 24, 1984
    Date of Patent: January 7, 1986
    Assignee: Collagen Corporation
    Inventors: Ranga Nathan, Saied Seyedin, Karl Piez, Hanne Bentz
  • Polypeptide cartilage-inducing factors found in bone
    Patent number: RE34090
    Abstract: Two proteins that are found is bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: March 5, 1991
    Date of Patent: October 6, 1992
    Assignee: Celtrix Laboratories, Inc.
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong