Patents by Inventor Hanne Gissel Hyldkrog

Hanne Gissel Hyldkrog has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for refolding of denatured proteins
    Patent number: 9572340
    Abstract: Compounds and methods for refolding of proteins in an aqueous solution. In particular, biocompatible multiblock copolymer surfactants such as poloxamers, meroxapols, poloxamines, or polyols are used to catalyze proper refolding without changing the protein composition, and restore the protein to its native conformation and native biological function. The methods can be practiced both in vivo and in vitro. The biocompatible multiblock copolymer surfactants can be used for renaturation of recombinantly expressed proteins, and for renaturation of proteins that are unfolded due to heat, irradiation, mechanical shearing, electrical shock, frostbite, chemical stress, and other abiotic or biotic stresses.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: February 21, 2017
    Assignee: UNIVERSITY OF CHICAGO
    Inventors: Raphael C Lee, Annie Kuo, Hanne Gissel Hyldkrog, Florin Despa, Devkumar Mustafi
  • Compositions and Methods for Refolding of Denatured Proteins
    Publication number: 20140342345
    Abstract: Compounds and methods for refolding of proteins in an aqueous solution. In particular, biocompatible multiblock copolymer surfactants such as poloxamers, meroxapols, poloxamines, or polyols are used to catalyze proper refolding without changing the protein composition, and restore the protein to its native conformation and native biological function. The methods can be practiced both in vivo and in vitro. The biocompatible multiblock copolymer surfactants can be used for renaturation of recombinantly expressed proteins, and for renaturation of proteins that are unfolded due to heat, irradiation, mechanical shearing, electrical shock, frostbite, chemical stress, and other abiotic or biotic stresses.
    Type: Application
    Filed: August 4, 2014
    Publication date: November 20, 2014
    Inventors: Raphael C. Lee, Annie Kuo, Hanne Gissel Hyldkrog, Florin Despa, Devkumar Mustafi
  • Compositions and methods for refolding of denatured proteins
    Patent number: 8815557
    Abstract: Compounds and methods for refolding of proteins in an aqueous solution. In particular, biocompatible multiblock copolymer surfactants such as poloxamers, meroxapols, poloxamines, or polyols are used to catalyze proper refolding without changing the protein composition, and restore the protein to its native conformation and native biological function. The methods can be practiced both in vivo and in vitro. The biocompatible multiblock copolymer surfactants can be used for renaturation of recombinantly expressed proteins, and for renaturation of proteins that are unfolded due to heat, irradiation, mechanical shearing, electrical shock, frostbite, chemical stress, and other abiotic or biotic stresses.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: August 26, 2014
    Assignee: University of Chicago
    Inventors: Raphael C. Lee, Annie Kuo, Hanne Gissel Hyldkrog, Florin Despa, Devkumar Mustafi