Patents by Inventor Hanne Groen

Hanne Groen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immune response modulator alpha-2 macroglobulin complex
    Patent number: 6403092
    Abstract: Activation of &agr;2-macroglobulin (&agr;2M) with a nucleophilic compound followed by incubation of the activated &agr;2M at elevated temperature with a biomolecule results in covalent incorporation of the intact biomolecule into the &agr;2M molecule, without the use of proteinases. The thus-formed structurally defined and stable complex may be used as an antigen for stimulating the immune response, for example, in the form of a vaccine. Enhanced antigen presentation of a particular biomolecule is provided, especially for those that are poorly immunogenic; reduction of the immunodominance of particular epitopes is also provided.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: June 11, 2002
    Assignee: Duke University
    Inventors: Salvatore Pizzo, Hanne Grøn
  • Oxidation stable detergent enzymes
    Patent number: 5208158
    Abstract: Novel chemically modified detergent enzymes are provided, wherein one or more methionines have been mutated into cysteines, said cysteines subsequently being chemically modified in order to confer the enzyme improved stability towards oxidative agents. A novel process for stabilizing detergent enzymes against oxidation is also provided. Furthermore, there are provided detergent compositions comprising these novel oxidation stable detergent enzymes.
    Type: Grant
    Filed: July 17, 1990
    Date of Patent: May 4, 1993
    Assignee: Novo Nordisk A/S
    Inventors: Lene M. Bech, Sven Branner, Klaus Breddam, Hanne Groen