Patents by Inventor Hannes NICKISCH

Hannes NICKISCH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210110543
    Abstract: A computing system (118) includes a computer readable storage medium (122) with computer executable instructions (124), including a including a biophysical simulator (126) with a segmentor (202) and a boundary condition determiner (206). The computing system further includes a processor (120) configured to execute the biophysical simulator to compute a fractional flow reserve index with cardiac imaging data and at least one of an adapted coronary tree segmentation and an adapted boundary condition.
    Type: Application
    Filed: April 6, 2018
    Publication date: April 15, 2021
    Inventors: HANNES NICKISCH, HOLGER SCHMITT
  • Publication number: 20210100522
    Abstract: The present invention relates to a determination of a physiological functional parameter of a living being. Ultrasound image data and Doppler image data of a vessel structure are provided (101) and registered (102). The vessel structure is segmented (103) to generate (104) a representation of the vessel structure. The flow velocity inside a vessel of the vessel structure is determined (105) based on the Doppler image data. A physiological functional parameter determination model defining a value of a functional physiological parameter in dependence of a representation of a vessel structure and a flow velocity inside a vessel of the vessel structure is used (106) to determine (107) the physiological functional parameter inside the vessel of the vessel structure. The representation of the vessel structure and/or the flow velocity values can be constantly updated upon receipt of further input images to provide an estimation of the functional physiological parameter in real-time.
    Type: Application
    Filed: April 2, 2018
    Publication date: April 8, 2021
    Inventors: Hannes NICKISCH, Michael GRASS, Christian HAASE, Holger SCHMITT
  • Publication number: 20210073978
    Abstract: A system (100) includes a computer readable storage medium (122) with computer executable instructions (124), including: a predictor (126) configured to determine a baseline coronary state and a predicted coronaiy state from contrast enhanced cardiac computed tomography volumetric image data and a model of an effect of one or more substances on characteristics effecting the coronaiy state. The system further includes a processor (120) configured to execute the predictor to determine the baseline coronary state and the predicted coronary state from the contrast enhanced cardiac computed tomography volumetric image data and the model of the effect of one or more of the substances on the characteristics effecting the coronary state. The system further includes a display configured to display the baseline coronaiy state and the predicted coronaiy state.
    Type: Application
    Filed: August 17, 2018
    Publication date: March 11, 2021
    Inventors: Holger SCHMITT, HANNES NICKISCH, TOBIAS WISSEL
  • Patent number: 10902606
    Abstract: A system (100) for segmenting a coronary artery vessel tree (182) of a patient heart in a three dimensional (3D) cardiac image (120) includes a coronary volume definition unit (150) and a coronary artery segmentation unit (180). The coronary volume definition unit (150) sets a spatial boundary (210, 220) from internal and external surfaces of heart tissues in the 3D cardiac image based on a fitted heart model (200). The coronary artery segmentation unit (180) segments the coronary artery vessel tree (182) in the 3D cardiac image using a segmentation algorithm with a search space limited by the spatial boundary set from the internal and external surfaces of the heart tissues.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: January 26, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Cristian Lorenz, Tobias Klinder, Holger Schmitt, Hannes Nickisch
  • Patent number: 10898267
    Abstract: Stenosis information is obtained by obtaining photographic image data (302) from a displayed image of a blood vessel (103, 203) containing the stenosis. Contours of the blood vessel and the stenosis are detected and dimensions are estimated from the photographic image data. A blood vessel model is reconstructed and fractional flow reserve data is calculated using the blood vessel model.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: January 26, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Holger Schmitt, Christian Haase, Hannes Nickisch, Sven Prevrhal
  • Publication number: 20200410673
    Abstract: The disclosure relates to a system for image decomposition of an anatomical projection image. The system comprises a data processing system which implements a decomposition algorithm of an projection image which is generated by irradiating a part of a subject with imaging radiation. A body portion within the irradiated part is a three-dimensional attenuation structure of an attenuation of the imaging radiation, wherein the attenuation structure represents a member of a predefined class of attenuation structures of the decomposition algorithm, thereby representing a classification of the body portion. The data processing system decomposes the projection image data using the classification of the attenuation structure. The decomposition of the projection image data substantially separates the contribution of the classified body portion to the projection image from the contribution of a further body portion of the subject to the projection image.
    Type: Application
    Filed: January 9, 2019
    Publication date: December 31, 2020
    Inventors: IVO MATTEO BALTRUSCHAT, TOBIAS KNOPP, HANNES NICKISCH, AXEL SAALBACH
  • Publication number: 20200411189
    Abstract: A system (SY) for determining a relative importance of each of a plurality of image features (Fn) of a vascular medical image impacting an overall diagnostic metric computed for the image from an automatically-generated diagnostic rule. A medical kin image database (MIDB) includes a plurality of vascular medical images (M1 . . . k). A rule generating unit (RGU) analyzes the plurality of C vascular medical images and automatically generates at least one diagnostic rule corresponding to a common diagnosis of a subset of the plurality of vascular medical images based on a plurality of image features common to the subset of vascular medical images. An image providing unit (IPU) provides a current vascular medical image (CVMI) including the plurality of image features. A diagnostic metric computation unit (DMCU) computes an overall diagnostic metric for the current vascular medical image by applying the at least one automatically-generated diagnostic rule to the current vascular medical image.
    Type: Application
    Filed: March 4, 2019
    Publication date: December 31, 2020
    Inventors: TOBIAS WISSEL, HANNES NICKISCH, MICHAEL GRASS
  • Publication number: 20200397294
    Abstract: A system SY for determining a position of an OCT or IVUS catheter CA in a vasculature VA. The system SY includes a map-providing unit MPU, a data-providing unit DPU, and a comparator unit COMP. The map-providing unit is configured to provide a reference map SOM including reference measurement data at each of a plurality of positions P1 . . . k of the OCT or IVUS catheter CA in the vasculature VA. The data-providing unit DPU is configured to provide actual measurement data from an actual position in the vasculature VA. The comparator unit COMP is configured to determine from the plurality of positions P1 . . . k of the OCT or IVUS catheter in the vasculature, a position Pn?1 . . . k that corresponds to the actual position in the vasculature, based on a comparison of the actual measurement data and the reference measurement data. The reference measurement data and the actual measurement data are either i) OCT data or ii) IVUS data.
    Type: Application
    Filed: March 7, 2019
    Publication date: December 24, 2020
    Inventors: Tobias WISSEL, Hannes NICKISCH, Michael GRASS
  • Publication number: 20200402646
    Abstract: A medical image annotation system for analyzing a medical image. A plurality of image annotation tools are provided by the image annotation system, each of which is configured to perform, for one or more regions of interest of the medical image, at least a portion of an annotation. A recording module of the image annotation system is configured to record, for each of the regions of interest, interactions which are performed using the image annotation tools. The image annotation system is configured to compute an image annotation complexity metric for each of the regions of interest, based on the recorded interactions. Further, a presentation of the annotation tools by the user interface is indicative of an order, wherein the order is changed in response to the region of interest from which the user input is currently received.
    Type: Application
    Filed: February 27, 2019
    Publication date: December 24, 2020
    Inventors: Hannes NICKISCH, Tobias WISSEL, Michael GRASS
  • Publication number: 20200337664
    Abstract: The present invention relates to a device (1) for fractional flow reserve determination. The device (1) comprises a model generator (10) configured to generate a three-dimensional model (3DM) of a portion of an imaged vascular vessel tree (VVT) surrounding a stenosed vessel segment (SVS), based on a partial segmentation of the imaged vascular vessel tree (VVT). Further, the device comprises an image processor (20) configured to calculate a blood flow (Q) through the stenosed vessel segment (SVS) based on an analysis of a time-series of X-ray images of the vascular vessel tree (VVT). Still further, the device comprises a fractional-flow-reserve determiner (30) configured to determine a fractional flow reserve (FFR) based on the three-dimensional model (3DM) and the calculated blood flow.
    Type: Application
    Filed: July 7, 2020
    Publication date: October 29, 2020
    Inventors: Hanno Heyke HOMANN, Michael GRASS, Raoul FLORENT, Holger SCHMITT, Odlie BONNEFOUS, Hannes NICKISCH
  • Publication number: 20200060637
    Abstract: A computing system (118) includes a computer readable storage medium (122) with computer executable instructions (124), including a biophysical simulator (126), and a reference location (128), and a processor (120) configured to the biophysical simulator and simulate a reference FFR value at a predetermined location along a segmented coronary vessel indicated by the reference location. A computer readable storage medium encoded with computer readable instructions, which, when executed by a processor of a computing system, causes the processor to simulate a reference FFR value at a predetermined location along a segmented coronary vessel indicated by a predetermined reference location. A method including simulating a reference FFR value at a predetermined location along a segmented coronary vessel indicated by a predetermined reference location.
    Type: Application
    Filed: April 2, 2018
    Publication date: February 27, 2020
    Inventors: HOLGER SCHMITT, HANNES NICKISCH, MANINDRANATH VEMBAR
  • Publication number: 20190318475
    Abstract: A computing system (126) includes a computer readable storage medium (130) with computer executable instructions (128), including: a segmentation standardizer (120) configured to determine a standardized vascular tree from a segmented vascular tree segmented of volumetric image data and a predetermined set of pruning rules (206), and a biophysical simulator (122) configured to perform a biophysical simulation based on the standardized vascular tree. The computing system further includes a processor (124) configured to execute the segmentation standardizer to determine the standardized vascular tree from the segmented vascular tree segmented of volumetric image data and the predetermined set of pruning rules, and configured to execute the biophysical simulator to perform a biophysical simulation based on the standardized vascular tree. The computing system further includes a display configured to display at least one of the standardized vascular tree and a result of the biophysical simulation.
    Type: Application
    Filed: November 16, 2017
    Publication date: October 17, 2019
    Inventors: Hannes NICKISCH, Holger SCHMITT, Sven PREVRHAL, Mordechay Pinchas FREIMAN, Liran GOSHEN
  • Publication number: 20190209115
    Abstract: The present invention relates to an apparatus (26) and a method for determining a fractional flow reserve. For this purpose, a new personalized hyperemic boundary condition model is provided. The personalized hyperemic boundary condition model is used to condition a parametric model for a simulation of a blood flow in a coronary tree (34) of a human subject. As a basis for the personalized hyperemic boundary condition 5 model, a predefined hyperemic boundary condition model is used, which represents empirical derived hyperemic boundary condition parameters. However, these empirical hyperemic boundary condition parameters are not specific for a human subject under examination. In order to achieve a specification of the respective predefined hyperemic boundary condition model, specific human subject features are derived from a volumetric image of the coronary 10 tree of the human subject.
    Type: Application
    Filed: September 15, 2017
    Publication date: July 11, 2019
    Inventors: Mordechay Pinchas FREIMAN, Liran GOSHEN, Hannes NICKISCH
  • Patent number: 10282846
    Abstract: A method is provided for generating a deformable model (300) for segmenting an anatomical structure in a medical image. The anatomical structure comprises a wall. The deformable model (300) is generated such that it comprises, in addition to two surface meshes (320, 360), an intermediate layer mesh (340) for being applied in-between a first surface layer of the wall and a second surface layer of the wall. In generating the intermediate layer mesh (340), the mesh topology of at least part (400) of the intermediate layer mesh is matched to the mesh topology of one of the surface meshes (320, 360), thereby establishing matching mesh topologies. The deformable model (300), as generated, better matches the composition of such walls, thereby providing a more accurate segmentation.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: May 7, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Alexandra Groth, Hannes Nickisch, Frank Michael Weber, Juergen Weese, Hans Barschdorf
  • Patent number: 10258303
    Abstract: The invention relates to an apparatus for determining a fractional flow reserve (FFR) value of the coronary artery system of a living being (3). A fractional flow reserve value determination unit (13) determines the FFR value by using an FFR value determination algorithm that is adapted to determine the FFR value based on a boundary condition and a provided representation of the coronary artery system, wherein the boundary condition is specific for the living being and determined by a boundary condition determination unit (12). Since the boundary condition determination unit determines a boundary condition, which is specific for the living being, and since the fractional flow reserve value determination unit not only uses the provided representation of the coronary artery system, but also the living being specific boundary condition for determining the FFR value, the accuracy of the FFR value, which is non-invasively determined, can be improved.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: April 16, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Michael Grass, Yechiel Lamash, Liran Goshen, Holger Schmitt, Mordechay Pinchas Freiman, Hannes Nickisch, Sven Prevrhal
  • Publication number: 20190083052
    Abstract: The present invention relates to a device (1) for fractional flow reserve determination. The device (1) comprises a model generator (10) configured to generate a three-dimensional model (3DM) of a portion of an imaged vascular vessel tree (VVT) surrounding a stenosed vessel segment (SVS), based on a partial segmentation of the imaged vascular vessel tree (VVT). Further, the device comprises an image processor (20) configured to calculate a blood flow (Q) through the stenosed vessel segment (SVS) based on an analysis of a time-series of X-ray images of the vascular vessel tree (VVT). Still further, the device comprises a fractional-flow-reserve determiner (30) configured to determine a fractional flow reserve (FFR) based on the three-dimensional model (3DM) and the calculated blood flow.
    Type: Application
    Filed: December 1, 2015
    Publication date: March 21, 2019
    Inventors: Hanno Heyke HOMANN, Michael GRASS, Raoul FLORENT, Holger SCHMITT, Odile BONNEFOUS, Hannes NICKISCH
  • Publication number: 20190038356
    Abstract: Stenosis information is obtained by obtaining photographic image data (302) from a displayed image of a blood vessel (103, 203) containing the stenosis. Contours of the blood vessel and the stenosis are detected and dimensions are estimated from the photographic image data. A blood vessel model is reconstructed and fractional flow reserve data is calculated using the blood vessel model.
    Type: Application
    Filed: September 26, 2016
    Publication date: February 7, 2019
    Inventors: Holger SCHMITT, Christian HAASE, Hannes NICKISCH, Sven PREVRHAL
  • Publication number: 20180365838
    Abstract: A system (100) for segmenting a coronary artery vessel tree (182) of a patient heart in a three dimensional (3D) cardiac image (120) includes a coronary volume definition unit (150) and a coronary artery segmentation unit (180). The coronary volume definition unit (150) sets a spatial boundary (210, 220) from internal and external surfaces of heart tissues in the 3D cardiac image based on a fitted heart model (200). The coronary artery segmentation unit (180) segments the coronary artery vessel tree (182) in the 3D cardiac image using a segmentation algorithm with a search space limited by the spatial boundary set from the internal and external surfaces of the heart tissues.
    Type: Application
    Filed: December 19, 2016
    Publication date: December 20, 2018
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Cristian LORENZ, Tobias KLINDER, Holger SCHMITT, Hannes NICKISCH
  • Publication number: 20180360405
    Abstract: A system (100) for a targeted perfusion scan includes a computed tomography (CT) scanner (120), a feeding territory map (132) and a targeted perfusion unit (140). The CT scanner (120) performs a perfusion scan of a portion of tissues of an organ. The feeding territory map (132) maps arterial locations of an arterial vessel tree to spatially located organ tissues of the organ fed by the arterial locations. The targeted perfusion unit (140) includes one or more processors (164) configured to determine targeted coverage (200) from a location of a stenosis (112, 210) and the feeding territory map, and to control the CT scanner to perform the perfusion scan according to the determined targeted coverage.
    Type: Application
    Filed: December 20, 2016
    Publication date: December 20, 2018
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Sven PREVRHAL, Holger SCHMITT, Hannes NICKISCH
  • Patent number: 10111633
    Abstract: A system (IPS) and related method for fractional flow reserve, FFR, simulation. The simulation for a range of FFR values for a vasculature portion is based on a composite transfer function which is combined from a weighted sum of global effect transfer functions he, each representing a distinct physical effect that causes a pressure drop. The weights we are gotten from a previous training phase against pressure pi versus flow rate fi 5 sample measurements associated with respective vasculature geometries. The simulated range of FFR values is visualized in a graphics display (GD) as a function of pressure and flow rate values within respective intervals.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: October 30, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hannes Nickisch, Michael Grass, Holger Schmitt, Jan Timmer