Patents by Inventor Hanno L. Tan

Hanno L. Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160333071
    Abstract: It is demonstrated that hyperpolarization-activated cyclic nucleotide-gated (HCN)-based biological pacing, especially that achieved by transduction of the HCN2 gene into cardiac cells in vivo, was significantly improved by co-transduction of the skeletal muscle sodium channel 1 (SkMI) gene. Expression of both genes hyperpolarized the action potential (AP) threshold. When viral biological pacemaker constructs carrying genes for HCN2 and SkMI were injected into the heart of dogs in vivo, the pacemaker function was facilitated by the slow depolarizing HCN2 current and the hyperpolarized AP threshold generated by SkMI. This dual gene therapy provided both highly efficient pacing and a brisk autonomic response that is superior to those of previously developed gene- or cell-based approaches.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 17, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Michael R. Rosen, Gerard J. Boink, Hanno L Tan, Richard B. Robinson, Ira S. Cohen, Peter R. Brink, Peter Danilo, Jr.
  • Publication number: 20110077702
    Abstract: The invention provides means and methods for providing a cell with a spontaneous electrical activity and means and methods for increasing the depolarization rate of a cell having a spontaneous electrical activity. Means and methods are provided comprising: providing a cell with a compound capable of providing and/or increasing a pacemaker current If, and diminishing electrical coupling between said cell and surrounding cells and/or reducing the inward rectifier current IK1 of said cell, and or increasing the availability of INa at depolarized potentials, preferably using overexpression of additional sodium channels.
    Type: Application
    Filed: September 27, 2010
    Publication date: March 31, 2011
    Applicant: Academisch Medisch Centrum Bij de Universiteit van Amsterdam
    Inventors: Gerard J.J. Boink, Hanno L. Tan, Jacques De Bakker Milo Thomas