Patents by Inventor Hanno Schieferstein

Hanno Schieferstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gamma-carboline compounds for the detection of Tau aggregates
    Patent number: 11306089
    Abstract: The present invention relates to novel compounds of the formula (II) and formula (III) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: April 19, 2022
    Assignee: LIFE MOLECULAR IMAGING LIMITED
    Inventors: Mathias Berndt, Andre Müller, Felix Oden, Hanno Schieferstein, Heribert Schmitt-Willich, Heiko Kroth, Jérôme Molette
  • GAMMA-CARBOLINE COMPOUNDS FOR THE DETECTION OF TAU AGGREGATES
    Publication number: 20210047321
    Abstract: The present invention relates to novel compounds of the formula (II) and formula (III) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 18, 2021
    Inventors: Mathias BERNDT, Andre MÜLLER, Felix ODEN, Hanno SCHIEFERSTEIN, Heribert SCHMITT-WILLICH, Heiko KROTH, Jérôme MOLETTE
  • DIAGNOSTIC COMPOSITIONS FOR PET IMAGING, A METHOD FOR MANUFACTURING THE DIAGNOSTIC COMPOSITION AND ITS USE IN DIAGNOSTICS
    Publication number: 20210047327
    Abstract: The present application relates to a diagnostic composition comprising: a. a compound of Formula I, b. ethanol, c. water, and d. a hydroxycarboxylic acid, a salt of a hydroxycarboxylic acid or a mixture thereof. The diagnostic composition can be used in the selective detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease (AD) and other tauopathies, for example, using Positron Emission Tomography (PET). The present invention also relates to a method of preparing the claimed diagnostic composition.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 18, 2021
    Inventors: Johnny CASTILLO MELEAN, Thomas BETZEL, Mathias BERNDT, Hanno SCHIEFERSTEIN, Heiko KROTH, Jérôme MOLETTE, Vincent DARMENCY, Emanuele GABELLIERI
  • NOVEL METHOD OF PREPARING AN IMAGING COMPOUND
    Publication number: 20210038747
    Abstract: The present invention relates to a novel method of preparing a compound of the formula I. Diagnostic compositions and their use in the selective detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease (AD) and other tauopathies, for example, using Positron Emission Tomography (PET) imaging are also disclosed.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 11, 2021
    Inventors: Marion ZERNA, Mathias BERNDT, Hanno SCHIEFERSTEIN, Johnny CASTILLO MELEAN, Heiko KROTH, Jérôme MOLETTE, Vincent DARMENCY, Emanuele GABELLIERI
  • AZACARBOLINE COMPOUNDS FOR THE DETECTION OF TAU AGGREGATES
    Publication number: 20210041447
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging. The present invention also discloses intermediates which are useful in the preparation of these compounds.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 11, 2021
    Inventors: Mathias BERNDT, Andre MÜLLER, Felix ODEN, Hanno SCHIEFERSTEIN, Heribert SCHMITT-WILLICH, Heiko KROTH, Jérôme MOLETTE, Emanuele GABELLIERI, Cédric BOUDOU
  • Compounds for imaging Tau protein aggregates
    Patent number: 10865207
    Abstract: The present invention relates to novel compounds of the formula (I) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: December 15, 2020
    Assignees: AC IMMUNE S.A., LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Jérôme Molette, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden
  • Compounds for imaging Tau protein aggregates
    Patent number: 10835624
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: November 17, 2020
    Assignees: AC IMMUNE S.A., LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Jérôme Molette, Vincent Darmency, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden, Emanuele Gabellieri
  • Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins
    Patent number: 10662193
    Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: May 26, 2020
    Assignees: AC IMMUNE SA, LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Sreenivasachary Nampally, Jér{hacek over (o)}me Molette, Emanuele Gabellieri, Pascal André René Benderitter, Wolfgang Froestl, Hanno Schieferstein, Andre Mueller, Heribert Schmitt-Willich, Mathias Berndt
  • COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES
    Publication number: 20190263817
    Abstract: The present invention relates to novel compounds of the formula (I) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 29, 2019
    Inventors: Heiko KROTH, Jerome MOLETTE, Hanno SCHIEFERSTEIN, Andre MULLER, Heribert SCHMITT-WILLICH, Mathias BERNDT, Felix ODEN
  • COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES
    Publication number: 20190262480
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 29, 2019
    Inventors: Heiko KROTH, Jérôme MOLETTE, Vicent DARMENCY, Hanno SCHIEFERSTEIN, Andre MÜLLER, Heribert SCHMITT-WILLICH, Mathias BERNDT, Felix ODEN, Emanuele GABELLIERI
  • NOVEL IMAGING COMPOUNDS
    Publication number: 20180264146
    Abstract: The present invention relates to novel compounds that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: July 15, 2016
    Publication date: September 20, 2018
    Applicants: AC IMMUNE S.A., PIRAMAL IMAGING SA
    Inventors: Heiko KROTH, Sreenivasachary NAMPALLY, Jérôme MOLETTE, Emanuele GABELLIERI, Hanno SCHIEFERSTEIN, Andre MÜLLER, Heribert SCHMITT-WILLICH, Mathias BERNDT
  • Carbazole and Carboline Compounds for Use in the Diagnosis, Treatment, Alleviation or Prevention of Disorders Associated with Amyloid or Amyloid-Like Proteins
    Publication number: 20170002005
    Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.
    Type: Application
    Filed: January 21, 2015
    Publication date: January 5, 2017
    Inventors: Heiko KROTH, Sreenivasachary NAMPALLY, Jérôme MOLETTE, Emanuele GABELLIERI, Pascal André René BENDERITTER, Wolfgang FROESTL, Hanno SCHIEFERSTEIN, Andre MUELLER, Heribert SCHMITT-WILLICH, Mathias BERNDT
  • Simple, rapid method for the preparation of isotopically labeled formaldehyde
    Patent number: 8030526
    Abstract: Isotopically labeled formaldehyde (*C§H2O) is prepared from labeled methyl iodide (*C§H3I) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *C§H2O with little or no *C isotopic dilution. The simple, efficient production of 11CH2O is described. The use of the 11CH2O for the formation of positron emission tomography tracer compounds is described. The reaction can be incorporated into automated equipment available to radiochemistry laboratories. The isotopically labeled formaldehyde can be used in a variety of reactions to provide radiotracer compounds for imaging studies as well as for scintillation counting and autoradiography.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: October 4, 2011
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Jacob Matthew Hooker, Matthias Schonberger, Hanno Schieferstein, Joanna S. Fowler
  • Simple, Rapid Method for the Preparation of Isotopically Labeled Formaldehyde
    Publication number: 20090317880
    Abstract: Isotopically labeled formaldehyde (*C§H2O) is prepared from labeled methyl iodide (*C§H3I) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *C§H2O with little or no *C isotopic dilution. The simple, efficient production of 11CH2O is described. The use of the 11CH2O for the formation of positron emission tomography tracer compounds is described. The reaction can be incorporated into automated equipment available to radiochemistry laboratories. The isotopically labeled formaldehyde can be used in a variety of reactions to provide radiotracer compounds for imaging studies as well as for scintillation counting and autoradiography.
    Type: Application
    Filed: June 22, 2009
    Publication date: December 24, 2009
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES, LLC
    Inventors: Jacob Matthew Hooker, Mathias Schonberger, Hanno Schieferstein, Joanna S. Fowler