Patents by Inventor Hanno Steen
Hanno Steen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11698378Abstract: This disclosure relates to methods of determining the amount of post translational modification (PTM) associated with one or more tau peptide fragments of a tau protein in a sample, and methods of evaluating a subject for having a tauopathy, the methods comprising, in part, determining the amount of post translational modification (PTM) associated with one or more tau peptide fragments of a tau protein in a sample, and comparing the amount of the tau PTMs associated with one or more tau peptide fragments with one or more reference levels for the tau peptide fragments, thereby determining whether a subject has a tauopathy.Type: GrantFiled: September 23, 2016Date of Patent: July 11, 2023Assignee: Children's Medical Center CorporationInventors: Judith AJ Steen, Hanno Steen, Waltraud Mair, Jan Muntel, Shaojun Tang
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Publication number: 20210033505Abstract: A method for rapid isolation of a biological compound (e.g. protein) from an aqueous sample is described herein. The method uses a porous hydrophobic membrane that has an average pore size significantly greater than the size of the biological compound. The method permits the biological compound to attach to the membrane while the aqueous solvent rapidly moves through the membrane under the application of a vacuum. The biological compound that is attached to the membrane can be washed, optionally digested, and eluted for analysis.Type: ApplicationFiled: October 9, 2020Publication date: February 4, 2021Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Hanno STEEN, Sebastian T. BERGER, Saima AHMED
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Publication number: 20190234966Abstract: This disclosure relates to methods of determining the amount of post translational modification (PTM) associated with one or more tau peptide fragments of a tau protein in a sample, and methods of evaluating a subject for having a tauopathy, the methods comprising, in part, determining the amount of post translational modification (PTM) associated with one or more tau peptide fragments of a tau protein in a sample, and comparing the amount of the tau PTMs associated with one or more tau peptide fragments with one or more reference levels for the tau peptide fragments, thereby determining whether a subject has a tauopathy.Type: ApplicationFiled: September 23, 2016Publication date: August 1, 2019Inventors: Judith AJ Steen, Hanno Steen, Waltraud Mair, Jan Muntel, Shaojun Tang
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Publication number: 20180224466Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in appendicitis patients and in patients at risk for appendicitis. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients.Type: ApplicationFiled: June 17, 2016Publication date: August 9, 2018Applicants: ASTUTE MEDICAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Paul McPHERSON, James Patrick KAMPF, Thomas KWAN, Richard BACHUR, Hanno STEEN
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Patent number: 9933439Abstract: Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers: leucine-rich ?-2-glycoprotein (LRG); S100-A8 (calgranulin); ?-1-acid glycoprotein 1 (ORM); plasminogen (PLG); mannan-binding lectin serine protease 2 (MASP2); zinc-?-2-glycoprotein (AZGP1); Apolipoprotein D (ApoD); and ?-1-antichymotrypsin (SERPINA3); are increased in the urine of patients with appendicitis. The method and devices comprise detecting the levels of these biomarkers and comparing with reference levels found in healthy individuals.Type: GrantFiled: October 3, 2014Date of Patent: April 3, 2018Assignee: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Alex Kentsis, Hanno Steen, Richard Bachur
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Patent number: 9869673Abstract: The present invention provides for compositions and methods for diagnosing and treating Kawasaki disease. More specifically, the proteomes of patients with KD are enriched for the meprin A, filamin B, and filamin C, which serve as biomarkers (and potential therapeutic targets) for KD. Accordingly, detection of these biomarkers, using compositions and methods provided for herein, can inform the therapy delivered to the subject.Type: GrantFiled: April 13, 2012Date of Patent: January 16, 2018Assignee: The Children's Medical Center CorporationInventors: Alex Kentsis, Susan Kim, Hanno Steen
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Publication number: 20170370813Abstract: A method for rapid isolation of a biological compound (e.g. protein) from an aqueous sample is described herein. The method uses a porous hydrophobic membrane that has an average pore size significantly greater than the size of the biological compound. The method permits the biological compound to attach to the membrane while the aqueous solvent rapidly moves through the membrane under the application of a vacuum. The biological compound that is attached to the membrane can be washed, optionally digested, and eluted for analysis.Type: ApplicationFiled: January 8, 2016Publication date: December 28, 2017Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Hanno STEEN, Sebastian T. BERGER, Saima AHMED
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Publication number: 20160327572Abstract: The present invention provides CSF protein-based biomarkers and biomarker combinations that are useful in diagnosing dementia or a dementia related neurological disorder a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's dementia, non-Alzheimer's dementia, as Progressive supranuclear palsy (PSP), non-PSP dementia or normal. In some aspects, the invention relates to methods useful for diagnosing, classifying, and profiling dementia or a dementia related neurological disorder a patient.Type: ApplicationFiled: January 6, 2015Publication date: November 10, 2016Inventors: Omar S. Barnaby, Judith Steen, Beth Stevens, Hanno Steen, Soyon Y. Hong
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Publication number: 20150031049Abstract: Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers: leucine-rich ?-2-glycoprotein (LRG); S100-A8 (calgranulin); ?-1-acid glycoprotein 1 (ORM); plasminogen (PLG); mannan-binding lectin serine protease 2 (MASP2); zinc-?-2-glycoprotein (AZGP1); Apolipoprotein D (ApoD); and ?-1-antichymotrypsin (SERPINA3); are increased in the urine of patients with appendicitis. The method and devices comprise detecting the levels of these biomarkers and comparing with reference levels found in healthy individuals.Type: ApplicationFiled: October 3, 2014Publication date: January 29, 2015Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Alex Kentsis, Hanno Steen, Richard Bachur
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Patent number: 8871453Abstract: Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers: leucine-rich ?-2-glycoprotein (LRG); S100-A8 (calgranulin); ?-1-acid glycoprotein 1 (ORM); plasminogen (PLG); mannan-binding lectin serine protease 2 (MASP2); zinc-?-2-glycoprotein (AZGP1); Apolipoprotein D (ApoD); and ?-1-antichymotrypsin (SERPINA3); are increased in the urine of patients with appendicitis. The method and devices comprise detecting the levels of these biomarkers and comparing with reference levels found in healthy individuals.Type: GrantFiled: August 9, 2013Date of Patent: October 28, 2014Assignee: Children's Medical Center CorporationInventors: Alex Kentsis, Hanno Steen, Richard Bachur
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Publication number: 20140161791Abstract: The present invention provides for compositions and methods for diagnosing and treating Kawasaki disease. More specifically, the proteomes of patients with KD are enriched for the meprin A, filamin B, and filamin C, which serve as biomarkers (and potential therapeutic targets) for KD. Accordingly, detection of these biomarkers, using compositions and methods provided for herein, can inform the therapy delivered to the subject.Type: ApplicationFiled: April 13, 2012Publication date: June 12, 2014Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Alex Kentsis, Susan Kim, Hanno Steen
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Publication number: 20130338243Abstract: Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers: leucine-rich ?-2-glycoprotein (LRG); S100-A8 (calgranulin); ?-1-acid glycoprotein 1 (ORM); plasminogen (PLG); mannan-binding lectin serine protease 2 (MASP2); zinc-?-2-glycoprotein (AZGP1); Apolipoprotein D (ApoD); and ?-1-antichymotrypsin (SERPINA3); are increased in the urine of patients with appendicitis. The method and devices comprise detecting the levels of these biomarkers and comparing with reference levels found in healthy individuals.Type: ApplicationFiled: August 9, 2013Publication date: December 19, 2013Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Alex Kentsis, Hanno Steen, Richard Bachur
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Patent number: 8535891Abstract: Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers: leucine-rich ?-2-glycoprotein (LRG); S100-A8 (calgranulin); ?-1-acid glycoprotein 1 (ORM); plasminogen (PLG); mannan-binding lectin serine protease 2 (MASP2); zinc-?-2-glycoprotein (AZGP1); Apolipoprotein D (ApoD); and ?-1-antichymotrypsin (SERPINA3); are increased in the urine of patients with appendicitis. The method and devices comprise detecting the levels of these biomarkers and comparing with reference levels found in healthy individuals.Type: GrantFiled: December 30, 2009Date of Patent: September 17, 2013Assignee: Children's Medical Center CorporationInventors: Alex Kentsis, Hanno Steen, Richard Bachur
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Publication number: 20130236977Abstract: Provided herein are composition, methods and kits for peptide analysis in blood by mass spectroscopy. Isotopic peptides are also provided that facilitate quantification of peptide levels, e.g., hepcidin levels, in blood by mass spectroscopy. Further disclosed are methods and compositions for quantifying blood hepcidin levels and evaluating iron-associated disorders.Type: ApplicationFiled: May 24, 2011Publication date: September 12, 2013Applicant: Children's Medical Center CorporationInventors: Hanno Steen, Damon Anderson
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Publication number: 20120028268Abstract: Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers: leucine-rich ?-2-glycoprotein (LRG); S100-A8 (calgranulin); ?-1-acid glycoprotein 1 (ORM); plasminogen (PLG); mannan-binding lectin serine protease 2 (MASP2); zinc-?-2-glycoprotein (AZGP1); Apolipoprotein D (ApoD); and ?-1-antichymotrypsin (SERPINA3); are increased in the urine of patients with appendicitis. The method and devices comprise detecting the levels of these biomarkers and comparing with reference levels found in healthy individuals.Type: ApplicationFiled: December 30, 2009Publication date: February 2, 2012Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Alex Kentsis, Hanno Steen, Richard Bachur
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Publication number: 20020192708Abstract: Methods and systems of applying mass spectrometry to the analysis of peptides and amino acids, especially in the proteome setting. More particularly, the invention relates to a mass spectrometry-based method for detection of amino acid modifications, such as phosphorylation.Type: ApplicationFiled: October 25, 2001Publication date: December 19, 2002Inventors: Hanno Steen, Bernhard Kuster, Matthias Mann