Patents by Inventor Hanns Lochmuller

Hanns Lochmuller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adeno-Associated Virus Vector Delivery of a Fragment of Micro-Dystrophin to Treat Muscular Dystrophy
    Publication number: 20230049491
    Abstract: The invention provides gene therapy vectors, such as adeno-associated virus (AAV) vectors, expressing a functional fragment of the miniaturized human micro-dystrophin gene and method of using these vectors to express the fragment of micro-dystrophin in skeletal muscles including diaphragm and cardiac muscle and to protect muscle fibers from injury, increase muscle strength and reduce and/or prevent fibrosis in subjects suffering from muscular dystrophy.
    Type: Application
    Filed: May 23, 2022
    Publication date: February 16, 2023
    Inventors: Hanns Lochmuller, Oliver Muller
  • Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy
    Patent number: 11338045
    Abstract: The invention provides gene therapy vectors, such as adeno-associated vims (AAV) vectors, expressing a functional fragment of the miniaturized human micro-dystrophin gene and method of using these vectors to express the fragment of micro-dystrophin in skeletal muscles including diaphragm and cardiac muscle and to protect muscle fibers from injury, increase muscle strength and reduce and/or prevent fibrosis in subjects suffering from muscular dystrophy.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: May 24, 2022
    Assignees: NEWCASTLE UNIVERSITY, University of Heidelberg
    Inventors: Hanns Lochmuller, Oliver Muller
  • ADENO-ASSOCIATED VIRUS VECTOR DELIVERY OF A FRAGMENT OF MICRO-DYSTROPHIN TO TREAT MUSCULAR DYSTROPHY
    Publication number: 20200078473
    Abstract: The invention provides gene therapy vectors, such as adeno-associated vims (AAV) vectors, expressing a functional fragment of the miniaturized human micro-dystrophin gene and method of using these vectors to express the fragment of micro-dystrophin in skeletal muscles including diaphragm and cardiac muscle and to protect muscle fibers from injury, increase muscle strength and reduce and/or prevent fibrosis in subjects suffering from muscular dystrophy.
    Type: Application
    Filed: March 16, 2018
    Publication date: March 12, 2020
    Inventors: Hanns Lochmuller, Oliver Muller
  • Chn-1/Chip-Antagonists For The Treatment Of Muscular Diseases
    Publication number: 20090053196
    Abstract: The present invention relates to a pharmaceutical composition comprising an inhibitor/negative regulator/antagonist of the mammalian ortholog of Caenorhabditis elegans CHN-1 and/or of the human CHIP (carboxyl-terminus of Hsc70 interacting protein). Furthermore, the use of said inhibitor/negative regulator/antagonist in medical and pharmaceutical settings is described. In addition, screening methods and tools for the identification of CHIP/CHN-1 inhibitors/antagonists are provided.
    Type: Application
    Filed: July 29, 2005
    Publication date: February 26, 2009
    Applicant: LUDWIG-MAXIMILLIANS-UNIVERSITAT MUNCHEN
    Inventors: Ralf Baumeister, Thorsten Hoppe, Britta Spanier, Hanns Lochmuller, Rolf Stucka