Patents by Inventor Hanns Mohler

Hanns Mohler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Steroid compound for use in the treatment of hepatic encephalopathy
    Patent number: 10342804
    Abstract: The present invention provides the steroidal compound 3?-ethynyl-3?-hydroxyandrostan-17-one oxime, or a pharmaceutically acceptable salt thereof, for use in treatment of hepatic encephalopathy.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: July 9, 2019
    Assignee: Umecrine Cognition AB
    Inventors: Magnus Doverskog, Hanns Möhler, Vicente Felipo, Torbjörn Bäckström
  • STEROID COMPOUND FOR USE IN THE TREATMENT OF HEPATIC ENCEPHALOPATHY
    Publication number: 20180015103
    Abstract: The present invention provides the steroidal compound 3?-ethynyl-3?-hydroxyandrostan-17-one oxime, or a pharmaceutically acceptable salt thereof, for use in treatment of hepatic encephalopathy.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Inventors: Magnus Doverskog, Hanns Möhler, Vicente Felipo, Torbjörn Bäckström
  • Steroid compound for use in the treatment of hepatic encephalopathy
    Patent number: 9801894
    Abstract: The present invention provides the steroidal compound 3?-ethynyl-3?-hydroxyandrostan-17-one oxime, or a pharmaceutically acceptable salt thereof, for use in treatment of hepatic encephalopathy.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: October 31, 2017
    Assignee: Umecrine Cognition AB
    Inventors: Magnus Doverskog, Hanns Möhler, Vicente Felipo, Torbjörn Bäckström
  • STEROID COMPOUND FOR USE IN THE TREATMENT OF HEPATIC ENCEPHALOPATHY
    Publication number: 20170056416
    Abstract: The present invention provides the steroidal compound 3?-ethynyl-3?-hydroxyandrostan-17-one oxime, or a pharmaceutically acceptable salt thereof, for use in treatment of hepatic encephalopathy.
    Type: Application
    Filed: November 15, 2016
    Publication date: March 2, 2017
    Inventors: Magnus Doverskog, Hanns Möhler, Vicente Felipo, Torbjörn Bäckström
  • STEROID COMPOUND FOR USE IN THE TREATMENT OF HEPATIC ENCEPHALOPATHY
    Publication number: 20160339040
    Abstract: The present invention provides the steroidal compound 3?-ethynyl-3?-hydroxyandrostan-17-one oxime, or a pharmaceutically acceptable salt thereof, for use in treatment of hepatic encephalopathy.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 24, 2016
    Inventors: Magnus Doverskog, Hanns Möhler, Vicente Felipo, Torbjöm Bäckström
  • Therapeutic delivery of adenosine into a tissue
    Publication number: 20050272149
    Abstract: The present invention relates to generation of embryonic stem cells and neural cells having deficient adenosine kinase gene on both alleles. The present invention further relates to methods of cell-based therapeutic delivery of agents and cells to a host tissue site for treatment of diseases.
    Type: Application
    Filed: June 2, 2004
    Publication date: December 8, 2005
    Inventors: Oliver Brustle, Peter Koch, Hanns Mohler, Detlev Boison
  • Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
    Patent number: 6110902
    Abstract: The present invention relates to the treatment of conditions associated with neuronal activity. Specifically, the invention is drawn to methods and compositions for administering adenosine to inhibit pain syndromes or epilepsy in a patient.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: August 29, 2000
    Inventors: Hanns Mohler, Detlev Boison
  • Process for preparing imidazodiazepines
    Patent number: 4363762
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of: ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: December 14, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Thieno-1,4-diazepin-5-ones and benzo-1,4-diazepin-5-ones
    Patent number: 4359420
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: November 16, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Imidazodiazepine derivatives
    Patent number: 4346032
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Process for preparing imidazodiazepines
    Patent number: 4346031
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Process for preparing imidazodiazepine derivatives
    Patent number: 4346036
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Thienodiazepinone and benzodiazepinone intermediates
    Patent number: 4346033
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Imidazodiazepine derivatives
    Patent number: 4346030
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Process for preparing imidazodiazepines
    Patent number: 4346035
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Process for preparing imidazodiazepines
    Patent number: 4346034
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is <C.dbd.O or <C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: August 24, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
  • Imidazodiazepine derivatives
    Patent number: 4316839
    Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.
    Type: Grant
    Filed: October 3, 1980
    Date of Patent: February 23, 1982
    Assignee: Hoffman-La Roche Inc.
    Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc