Abstract: The present invention is directed to a Gyrase inhibitor-protein conjugate; in particular a Gyrase inhibitor-albumin conjugate. The present invention further provides methods of the treatment of inflammatory conditions and tumors. Methods of making and producing a Gyrase inhibitor-protein conjugate are also disclosed.

Abstract: A method for modulating a transplantation-associated immune response in a subject is disclosed. The method comprises administering to the subject an effective amount of a conjugate comprising a carboxyl group-containing organic compound and albumin, wherein the carboxyl group-containing organic compound is a cytostatic or an immunosuppressant. A method for preparing the conjugate is also disclosed. The method includes activating the carboxyl group-containing organic compound with 1-ethyl-3-(3-dimethylaminopropyl) carbonyldiimide in an organic solvent, and reacting activated carboxyl group-containing organic compound with albumin, wherein the carboxyl group-containing organic compound is a cytostatic or an immunosuppressant.

Abstract: The present invention concerns NSAR (non-steroidal antirheumatic agents)-protein conjugates and in particular NSAR-albumin conjugates, processes for their production and their use as pharmaceutical preparations especially for treating inflammations.

Abstract: The present invention concerns gyrase inhibitor-protein conjugates and in particular gyrase inhibitor-albumin conjugates, pharmaceutical preparations comprising gyrase inhibitor-protein conjugates in particular for the treatment and/or prophylaxis of inflammatory processes and/or tumours as well as methods for their production.

Abstract: The invention relates to corticoid/transport protein conjugates, methods for the production thereof, and the use of the same in medicine, especially for the treatment of tumours and inflammatory processes, and for immunosuppression.

Abstract: The present invention relates to the use of active substance-protein conjugates for modulating and, in particular, for preventing transplantation-associated immune responses. In addition, the invention relates to novel, advantageous processes for preparing the conjugates which can be employed according to the invention.

Abstract: The present invention relates to conjugates for differentiating between healthy and unhealthy tissue, methods of producing such conjugates as well as their use.

Abstract: The invention relates to conjugates comprising a D-enantiomer of a folic acid antagonist and a carrier. Furthermore, the invention relates to the production of such conjugates as well as their use.

Abstract: The present invention relates to a conjugate comprising an active substance and a compound having a binding site for metallic compounds. In addition, this invention relates to a process for the preparation of such a conjugate and its use.

Abstract: The present invention relates to conjugates, comprising an active substance, a polypeptide and a polyether, a process for the production of such conjugates as well as their use.

Abstract: The invention relates to conjugates, comprising a fluorescent compound and a carrier, wherein the compound and the carrier are connected via an acidic ester or an acidic amide bond and the compound has an excitation wavelength of 630 nm or more and/or 450 nm or less. The invention also relates to the production of said conjugates and to the use thereof.

Abstract: The invention relates to a device for detecting input radiation such as X-rays, &ggr;-rays, ionizing radiation or fluorescent and low-level light. The device has at least one detection element comprising a sensor component (scintillator) for converting the input radiation into photons (scintillation light) in the UV, visible or IR part of the electromagnetic spectrum and an optical amplifier component which receives the light converted by the sensor component, forwards it for further processing and amplifies it at the same time. According to the invention, the amplifier component comprises at least one optical waveguide (1, 2, 2a, 2b, 20) whose material is optically pumped to amplify the scintillation light (3, 24, 25).

Abstract: The present invention relates to a process for preparing acid amides by reacting an acid with an aliphatic amine in molten urea. This invention also concerns a process for metalating compounds which can be bonded to a metal ion by reacting the compound with a metal ion in molten urea. Furthermore, the invention deals with the thus obtained products and their use for the therapy and/or diagnosis of tumors or inflammatory diseases.

Abstract: This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation for treating and/or diagnosing inflammatory, infectious and/or skin diseases.

Abstract: This invention relates to a process for the preparation of polyether-including chlorins and/or bacteriochlorins, comprising the following steps:(a) bonding a polyether to a porphyrin and(b) reacting the polyether-including porphyrin with a reducing agent.Furthermore, this invention concerns the polyether-including chlorins and bacteriochlorins, obtained by the process, as well as the use thereof for the photodynamic treatment of tumors.

Abstract: Radioactively tagged erythrocytes suitable for scintigraphic display.