Patents by Inventor Hannu Sariola

Hannu Sariola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intracellular Signaling-Induced Ret-Independent Gdnf Receptor-Effected Morphological Changes
    Publication number: 20080070264
    Abstract: The invention provides methods for identifying modulators of RETindependent, GDNF effected intracellular signaling. The invention further provides methods of identifying useful modulators of RET-independent GDNF receptoreffected MET activation, as well as modulators of morphological responses which are effected by nonRET GDNF receptor-effected intracellular signaling. Methods of distinguishing RET-independent GDNF ligand-mediated intracellular signaling by different cellular GDNF receptors from RET-dependent intracellular signaling are provided. The methods of the invention also provide an understanding of the complex interrelationships between RET, MET, GFRa in response to GDNF ligands.
    Type: Application
    Filed: March 5, 2004
    Publication date: March 20, 2008
    Applicant: JPMORGAN CHASE BANK N.A.
    Inventors: Hannu Sariola, Anna E. Popsueva, Mart Saarma
  • Gdnf-related neuropeptides
    Publication number: 20060258576
    Abstract: The invention provides novel neuropeptides having amino acid sequences derived from GDNF precursors and homologs thereof, as well as compositions containing the novel neuropeptides. The invention also provides polynucleotides encoding the neuropeptides, antibodies that specifically bind to the neuropeptides, and methods of making and using all of the above, particularly in the treatment of motor disorders, neuropathic pain, and for modulating excitatory neurotransmission.
    Type: Application
    Filed: September 3, 2004
    Publication date: November 16, 2006
    Applicant: Licentia, Ltd
    Inventors: Tiina Immonen, Hannu Sariola, Anniina Alakuijala, Michael Pasternack, Christophe Roos
  • Glial cell line-derived neurotrophic factor receptors
    Publication number: 20040126819
    Abstract: Receptors for Glial Cell Line-Derived Neurotrophic Factor (GDNF), their cellular expression, isolation, biochemical characterization, and sequences are disclosed. c-RET is disclosed as one receptor for GDNF; additional novel receptors are also disclosed. The preparation of monoclonal antibodies directed against GDNF is also disclosed.
    Type: Application
    Filed: September 26, 2003
    Publication date: July 1, 2004
    Inventors: Carlos F. Ibanez, Miles Trupp, Mart Saarma, Hannu Sariola, Urmas Arumae, Petro Suvanto
  • Assays using glial cell line-derived neurotrophic factor receptors
    Patent number: 6696259
    Abstract: Receptors for Glial Cell Line-Derived Neurotrophic Factor (GDNF), their cellular expression, isolation, biochemical characterization, and sequences are disclosed. c-RET is disclosed as one receptor for GDNF; additional novel receptors are also disclosed. The preparation of monoclonal antibodies directed against GDNF is also disclosed.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: February 24, 2004
    Assignee: Licentia Ltd.
    Inventors: Carlos F. Ibanez, Miles Trupp, Mart Saarma, Hannu Sariola, Urmas Arumäe, Petro Suvanto
  • Glial cell line-derived neurotrophic factor regulation of ureteric budding and growth
    Patent number: 5882923
    Abstract: The effect of GDNF on kidney morphogenesis is disclosed. Methods for stimulating budding and branching of the ureteric epithelium, for stimulating axonal outgrowth, for maintaining ureteric epithelial cells in culture, for preventing apoptosis of ureteric epithelial cells, and for treating diseases using GDNF are also disclosed.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: March 16, 1999
    Inventors: Hannu Sariola, Kirsi Sainio, Petro Suvanto, Urmas Arumae, Maria Lindahl, Mart Saarma