Abstract: The present invention relates to a method of vaccination via hair follicles that makes it possible to target vaccine components to the antigen-presenting cells in order to induce a protective and effective immune response against pathogens.

Abstract: The present invention relates to a method of vaccination via hair follicles that makes it possible to target vaccine components to the antigen-presenting cells in order to induce a protective and effective immune response against pathogens.

Abstract: Provided is a process of and product resulting from adding a sub-lethal amount of a peroxide, or said peroxide in combination with sub-lethal ultra violet radiation, to a growing culture of a yeast; observing the change in absorbance of the culture at 256 nm as a measure of the injury occurring to the yeast cells, and upon reaching a predetermined absorbance value, purifying the water-soluble yeast extract from the peroxide containing yeast culture. The resulting product has at least 1.5 respiratory units per mg dry weight and has significantly increased amounts of 15, 25 and 55 kilo Daltons (kD) molecular weight products compared to a Live Yeast Cell Derivative as determined by SDS slab gel electrophoresis. This product can be combined with a cosmetically acceptable carrier to provide a composition suitable for topical application to the skin.

Abstract: The invention is directed to a process of and product resulting from adding a sublethal amount of a peroxide to a growing culture of yeast, observing the change in absorbance of the culture at 256 nm as a measure of the injury occurring to the yeast cells, and, upon reaching a predeterimined absorbance value, purifying the water-soluble yeast extract from the peroxide containing yeast culture. The resulting product has at least 1.5 respiratory units per mg dry weight and has significantly increased amounts of 15, 25 and 55 kD molecular weight products compared to a Live Yeast Cell Derivative as determined by SDS slab gel electrophoresis. This product can be combined with a cosmetically acceptable carrier to provide a composition suitable for topical application to the skin.

Abstract: Provided is a process of and product resulting from adding a sub-lethal amount of a peroxide to a growing culture of yeast, observing the change in absorbance of the culture at 256 nm as a measure of the injury occurring to the yeast cells, and, upon reaching a predetermined absorbance value, purifying the water-soluble yeast extract from the peroxide containing yeast culture. The resulting product has at least 1.5 respiratory units per mg dry weight and has significantly increased amounts of 15, 25 and 55 kD molecular weight products compared to a Live Yeast Cell Derivative as determined by SDS slab gel electrophoresis. This product can be combined with a cosmetically acceptable carrier to provide a composition suitable for topical application to the skin.

Abstract: A liquid composition for the relief of discomfort, in particular, premenstrual and menstrual discomfort including, as active pharmaceutical agents, an effective amount of one or more of an analgesic, an antihistamine and a diuretic, said active agents being, or adapted to be, dissolved in a liquid vehicle, said composition preferably containing 5-25 percent by volume alcohol (or other effective liquid carrier such as glycerin, or even water) and being flavored with an active flavoring composition including (1) citrus and mint ingredients, (2) vanilla and mint ingredients, or (3) citrus, vanilla and mint ingredients, said active flavoring ingredients being present in an amount sufficient to mask the unpleasant taste of the pharmaceutically active agent(s).

Abstract: A liquid composition for the relief of discomfort, in particular, premenstrual and menstrual discomfort including, as active pharmaceutical agents, an effective amount of one or more of an analgesic, an antihistamine and a diuretic, the active agents being dissolved in a liquid vehicle, the composition containing 5-25 percent by volume alcohol and being flavored with an active flavoring composition including (1) citrus and mint ingredients, (2) vanilla and mint ingredients, or (3) citrus, vanilla and mint ingredients, the active flavoring ingredients being present in an amount sufficient to mask the unpleasant taste of the pharmaceutically active agents.

Abstract: The present invention provides methods for treating or preventing various dermatological conditions in humans, such as dry, cracked or damaged skin resulting from exposure to sunlight (ultraviolet radiation) and wind, aging effects, general skin dryness, e.g., deficient moisture content, and mild acne. These methods comprise applying an effective amount of a composition to the affected target area, the composition comprising a retinyl palmitate-polypeptide complex of apparent molecular weight of from about 5,000 to about 7,000 daltons, and an isoprenoid compound, e.g., a carotenoid such as beta-carotene.

Abstract: Absorption of Tissue Respiration Factor (TRF) into the gingival tissues is materially enhanced when it is formulated as a non-astringent hydrophilic pharmaceutical composition containing penetration promoting substances which are both hydrophilic and lipophilic. Additionally, a highly efficient means for effecting absorption of TRF into the gingival tissues is to utilize liposomes as carriers for the TRF in a non-astringent pharmaceutical composition.

Abstract: A liquid composition for the relief of premenstrual and menstrual discomfort comprising, as active pharmaceutical agents, an effective amount of an analgesic, an antihistamine, and a diuretic, said active agents being dissolved in a liquid vehicle, said composition containing 5-25 percent by volume alcohol and being flavored with active flavoring elements selected from the group consisting of citrus, vanilla, and mint, said active flavoring ingredients being present in an amount sufficient to mask the unpleasant taste of the pharmaceutically active agents.

Abstract: A composition useful in combatting gum disease comprising:(a) a non-neutralized gel component consisting essentially of hydrogen peroxide; an acrylic acid copolymer cross-linked with polyallyl sucrose; a polyol (glycerin, sorbitol, propylene glycol, polypropylene glycol, polyethylene glycol, an ethoxylated lower fatty alcohol, a propoxylated lower fatty alcohol and mixtures thereof); and purified water;(b) a paste component comprising: (i) sodium bicarbonate; (ii) a salt (NaCl, KCl, MgCl.sub.2, MgSO.sub.4, Na.sub.2 SO.sub.4, and K.sub.3 SO.sub.

Abstract: A composition useful in combatting gum disease including:(a) a gel component including (i) about 0.1-10% by weight of hydrogen peroxide; (ii) about 0.05-5.0% by weight of a water-dispersible copolymer of acrylic acid cross-linked with polyallyl sucrose; (iii) about zero to about 2.0% by weight of a nonionic cellulose stabilizer; (iv) a neutralizing agent selected from the group consisting of sodium hydroxide, potassium hydroxide, triethanolamine, diisopropylamine and ammonia in an amount sufficient to raise the gel pH to about 3-6.0; and (v) purified water;(b) a paste component including (i) about 2-60% sodium bicarbonate; (ii) about 1-6% of a salt selected from the group consisting of NaCl, MgCl.sub.2, MgSO.sub.4, Na.sub.2 SO.sub.4, and K.sub.2 SO.sub.

Abstract: Disclosed is a method for cleaning teeth including extruding a first semi-solid component including hydrogen peroxide as an active ingredient, and extruding a second semi-solid component comprising sodium bicarbonate as an active ingredient, the first and second components being suitable for oral use. The first component and the second component are placed in contact with each other on a toothbrush. The teeth are brushed using the first and second components concurrently as a cleaning medium.

Abstract: The invention is directed to a combination of a collapsible tube article having flexible side walls and a composition consisting of a gel component and a paste component and contained in said article, said combination being suitable for use in combatting gum disease, said article comprising:(a) a first compartment containing said gel, said gel comprising (i) 1-10% by volume of hydrogen peroxide, (ii) 0.05-1.2% by volume of a water dispersible copolymer of acrylic acid cross-linked with polyallyl sucrose; (iii) 0.1-1.