Patents by Inventor Hans Biebuyck

Hans Biebuyck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190257823
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: May 2, 2019
    Publication date: August 22, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Publication number: 20160245799
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: May 4, 2016
    Publication date: August 25, 2016
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Patent number: 9354230
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: May 31, 2016
    Assignee: MESO SCALE TECHNOLOGIES, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Patent number: 8530408
    Abstract: The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: September 10, 2013
    Assignee: Meso Scale Technologies LLC
    Inventors: Ilia Davydov, John H. Kenten, Hans Biebuyck, Pankaj Oberoi
  • Patent number: 7960904
    Abstract: The present invention relates to a field emission device comprising an anode and a cathode, wherein said cathode includes carbon nanotubes nanotubes which have been subjected to energy, plasma, chemical, or mechanical treatment. The present invention also relates to a field emission cathode comprising carbon nanotubes which have been subject to such treatment. A method for treating the carbon nanotubes and for creating a field emission cathode is also disclosed. A field emission display device containing carbon nanotube which have been subject to such treatment is further disclosed.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: June 14, 2011
    Assignee: Hyperion Catalysis International, Inc.
    Inventors: Mikio Takai, Alan B. Fischer, Chunming Niu, Howard G. Tennent, Robert Hoch, Hans Biebuyck
  • Publication number: 20110105354
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: December 23, 2010
    Publication date: May 5, 2011
    Applicant: MESO SCALE TECHNOLOGIES, LLC
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Patent number: 7875197
    Abstract: Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: January 25, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Younan Xia, James L. Wilbur, Rebecca J. Jackman, Enoch Kim, Mara G. Prentiss, Milan Mrksich, Amit Kumar, Christopher B. Gorman, Hans Biebuyck, Karl K. Berggren
  • Patent number: 7858321
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: December 28, 2010
    Assignee: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Publication number: 20100048485
    Abstract: The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
    Type: Application
    Filed: October 27, 2009
    Publication date: February 25, 2010
    Applicant: Meso Scale Technologies LLC
    Inventors: Ilia DAVYDOV, John H. Kenten, Hans Biebuyck, Pankaj Oberoi
  • Patent number: 7608682
    Abstract: The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: October 27, 2009
    Assignee: Meso Scale Technologies LLC
    Inventors: Ilia Davydov, John H. Kenten, Hans Biebuyck, Pankaj Oberoi
  • Publication number: 20090246076
    Abstract: An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
    Type: Application
    Filed: June 2, 2009
    Publication date: October 1, 2009
    Inventors: Sudeep M. Kumar, Josephus Marinus Otten, Charles Quentin Davis, Hans Biebuyck
  • Patent number: 7553448
    Abstract: An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: June 30, 2009
    Assignee: Bioveris Corporation
    Inventors: Sudeep M. Kumar, Josephus Marinus Otten, Charles Quentin Davis, Hans Biebuyck
  • Publication number: 20090001049
    Abstract: Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding.
    Type: Application
    Filed: August 6, 2008
    Publication date: January 1, 2009
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Younan Xia, James L. Wilbur, Rebecca J. Jackman, Enoch Kim, Mara G. Prentiss, Milan Mrksich, Amit Kumar, Christopher B. Gorman, Hans Biebuyck, Karl K. Berggren
  • Publication number: 20080203886
    Abstract: The present invention relates to a field emission device comprising an anode and a cathode, wherein said cathode includes carbon nanotubes nanotubes which have been subjected to energy, plasma, chemical, or mechanical treatment. The present invention also relates to a field emission cathode comprising carbon nanotubes which have been subject to such treatment. A method for treating the carbon nanotubes and for creating a field emission cathode is also disclosed. A field emission display device containing carbon nanotube which have been subject to such treatment is further disclosed.
    Type: Application
    Filed: August 20, 2007
    Publication date: August 28, 2008
    Applicant: Hyperion Catalysis International, Inc.
    Inventors: Mikio Takai, Alan B. Fischer, Chunming Niu, Howard G. Tennent, Robert Hoch, Hans Biebuyck
  • Publication number: 20070170414
    Abstract: The present invention relates to a field emission device comprising an anode and a cathode, wherein said cathode includes carbon nanotubes nanotubes which have been subjected to energy, plasma, chemical, or mechanical treatment. The present invention also relates to a field emission cathode comprising carbon nanotubes which have been subject to such treatment. A method for treating the carbon nanotubes and for creating a field emission cathode is also disclosed. A field emission display device containing carbon nanotube which have been subject to such treatment is further disclosed.
    Type: Application
    Filed: March 30, 2007
    Publication date: July 26, 2007
    Applicant: Hyperion Catalysis International, Inc.
    Inventors: Mikio Takai, Alan Fischer, Chunming Niu, Howard Tennent, Robert Hoch, Hans Biebuyck
  • Patent number: 7235464
    Abstract: The invention relates to a method for creating a pattern on a substrate comprising a first alignment structure, using an elastomeric stamp comprising a patterning structure and a second alignment structure. The method comprises a moving step for moving the elastomeric stamp towards the substrate, and a deformation step for deforming the patterning structure with a tensile or compressive force generated by cooperation of the first alignment structure and the second alignment structure.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: June 26, 2007
    Assignee: International Business Machines Corporation
    Inventors: Gian-Luca Bona, Bruno Michel, Hugo Eric Rothuizen, Peter Vettiger, Han Biebuyck
  • Patent number: 7063946
    Abstract: Apparatus, systems, system components, methods, compositions, and reagents for determining the function and activity of peptides and proteins and for identifying and characterizing molecules that affect these functions and activities. More specifically, methods and reagents used to determine the various activities of peptides and proteins including their binding specificity, binding activity, their enzymatic activity and their ability to act as substrates for enzymes. The disclosed methods are especially suited for the analysis of peptide and protein function where large numbers of peptides and proteins need to be analyzed.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: June 20, 2006
    Assignee: Meso Scale Technologies, LLC.
    Inventors: John H. Kenten, Hans Biebuyck, Ilia Davydov, Nisar Pampori, Steven Yan Cheng, Stefanie Nelson
  • Publication number: 20050275331
    Abstract: The present invention relates to a field emission device comprising an anode and a cathode, wherein said cathode includes carbon nanotubes nanotubes which have been subjected to energy, plasma, chemical, or mechanical treatment. The present invention also relates to a field emission cathode comprising carbon nanotubes which have been subject to such treatment. A method for treating the carbon nanotubes and for creating a field emission cathode is also disclosed. A field emission display device containing carbon nanotube which have been subject to such treatment is further disclosed.
    Type: Application
    Filed: August 4, 2005
    Publication date: December 15, 2005
    Applicant: Hyperion Catalysis International, Inc.
    Inventors: Mikio Takai, Alan Fischer, Chunming Niu, Howard Tennent, Robert Hoch, Hans Biebuyck
  • Publication number: 20050124092
    Abstract: The invention relates to a method for creating a pattern on a substrate comprising a first alignment structure, using an elastomeric stamp comprising a patterning structure and a second alignment structure. The method comprises a moving step for moving the elastomeric stamp towards the substrate, and a deformation step for deforming the patterning structure with a tensile or compressive force generated by cooperation of the first alignment structure and the second alignment structure.
    Type: Application
    Filed: May 28, 2003
    Publication date: June 9, 2005
    Inventors: Gian-Luca Bona, Bruno Michel, Hugo Rothuizen, Peter Vettiger, Han Biebuyck
  • Patent number: D499035
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: November 30, 2004
    Assignee: BioVeris Corporation
    Inventors: Richard Cook, Charles Quentin Davis, David Robert DeLalio, Pankaj Oberoi, Hans Biebuyck, Rober Krikor Matikyan, Neil S. Rothman, Christopher W. Glupker, Lance Hussey, Ravi K. Sawhney