Patents by Inventor Hans Bohn
Hans Bohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6537412Abstract: A process and an apparatus are provided for producing multilayers having on each of their two outer sides an outer metal foil and between them at least one additional layer. These foils and/or layer(s) are connected to each other by intermediate layers impregnated with adhesive, and the foils of several multilayers are stacked on top of each other, while a separation layer is inserted between them, and are then simultaneously pressed together. It is essential that the metal foil be placed around the separation layer on its underside, end side and upper side in a U-shape before the separation layer is supplied to the multilayer structure.Type: GrantFiled: December 23, 1999Date of Patent: March 25, 2003Assignee: Robert Burke GmbHInventor: Hans Bohn
-
Patent number: 6065584Abstract: A loading device for a plate press, composed of two loading supports which can be displaced perpendicular to a conveyance direction. Each loading support has at least one holding device with a conveyor belt which travels in the direction of conveyance. A workpiece to be processed is placed on the upper reach of the conveyor belt and is deposited by the conveyor belt in or on the press. The conveyor belt is moved in such a way that the relative speed of its upper reach in relation to a workpiece being conveyed is equal to zero for all states of movement of the assigned loading supports. As a result, no frictional movement occurs between the conveyor belt and workpieces being carried thereby.Type: GrantFiled: July 13, 1998Date of Patent: May 23, 2000Assignee: Robert Burkle GmbHInventor: Hans Bohn
-
Patent number: 4746731Abstract: A protein PP.sub.18 is isolated having the following characteristics:(a) an electrophoretic mobility in the region of that of .beta..sub.1 -globulins;(b) an isoelectric point between 5.6 and 6.2;(c) a sedimentation coefficient s.sub.20,w of 5.0.+-.0.2 S;(d) a molecular weight determined in an ultracentrifuge of 82,300.+-.5,600;(e) a carbohydrate fraction of 2.3.+-.1.3 g/100 g (mannose 0.15.+-.0.1, xylose 0.5.+-.0.5, galactose 0.5.+-.0.2, glucose 0.2.+-.0.1, N-acetylglucosamine 0.7.+-.0.2, and N-acetylneuraminic acid 0.25.+-.0.2, each g/100 g).Also described is the amino acid composition of the protein and a process for its isolation. Antiserum is prepared and used in an immunoassay to detect the protein.Type: GrantFiled: May 17, 1985Date of Patent: May 24, 1988Assignee: Behringwerke AktiengesellschaftInventors: Hans Bohn, Wilhelm Winckler
-
Patent number: 4599318Abstract: The protein PP.sub.19 which has(a) an electrophoretic mobility in the region between that of .alpha..sub.1 and of .beta..sub.1 globulins;(b) an isoelectric point between 4.6 and 5.4;(c) a sedimentation coefficient s.sub.20,w of 3.25.+-.0.25 S;(d) a molecular weight determined in the ultracentrifuge of 36,500.+-.4,000;(e) a carbohydrate fraction of 3.9.+-.1.5 g/100 g (mannose 0.3.+-.0.2, fucose 0.2.+-.0.1, galactose 1.0.+-.0.3, glucose 0.4.+-.0.2, N-acetylglucosamine 1.2.+-.0.3, N-acetylgalactosamine 0.1.+-.0.1, and N-acetylneuraminic acid 0.7.+-.0.3, each g/100 g); and(f) a particular amino acid composition,is described, as is a process for obtaining it.Type: GrantFiled: February 7, 1985Date of Patent: July 8, 1986Assignee: Behringwerke AktiengesellschaftInventors: Hans Bohn, Wilhelm Winckler
-
Patent number: 4594328Abstract: The protein PP.sub.21 which has the following characteristics:(a) an electrophoretic mobility in the region of that of .beta..sub.1 -globulins,(b) an isoelectric point of 4.6.+-.0.3;(c) a sedimentation coefficient s.sub.20,w of 3.2.+-.0.2 S;(d) a molecular weight determined in an ultracentrifuge of 52,900.+-.6,200;(e) an extinction coefficient E.sub.1 cm.sup.1% (280 nm) of 10.5.+-.1.0; and(f) a carbohydrate fraction of 19.2.+-.5.2 g/100 g (mannose 1.8.+-.0.4, galactose 4.3.+-.1.0, fucose 1.3+0.3, N-acetylglucosamine 6.5.+-.2.0 and N-acetylneuraminic acid 5.3.+-.1.5, each g/100 g),and a specified amino acid composition, a process for obtaining it and its use are described.Type: GrantFiled: March 21, 1985Date of Patent: June 10, 1986Assignee: Hoechst AktiengesellschaftInventors: Hans Bohn, Wilhelm Winckler
-
Patent number: 4592863Abstract: The protein PP.sub.20 is described, this having the following characteristics:(a) an electrophoretic mobility which is somewhat larger than that of albumin,(b) an isoelectric point of 4.65.+-.0.1,(c) a sedimentation coefficient s.sub.20,w of 4.1.+-.0.1 S,(d) a molecular weight determined by electrophoresis in sodium dodecyl sulfate (SDS)-containing polyacrylamide gel of 50,000.+-.10,000, the molecules of PP.sub.20 being composed of apparently identical subunits which have a molecular weight of 27,000.+-.3,000 and are held together non-covalently,(e) an extinction coefficient E.sub.1cm.sup.1% (280 nm) of 9.5.+-.0.6,(f) a carbohydrate content of 3.0.+-.1.3%, including mannose 0.14.+-.0.05%, fucose 0.13.+-.0.05%, galactose 0.61.+-.0.2%, glucose 0.39.+-.0.2%, N-acetylglucosamine 0.95.+-.0.3%, N-acetylgalactosamine 0.18.+-.0.1%, and N-acetylneuraminic acid 0.6.+-.0.4%.(g) a specified aminoacid composition, and a process for obtaining it is described.Type: GrantFiled: October 19, 1984Date of Patent: June 3, 1986Assignee: Behringwerke AktiengesellschaftInventors: Hans Bohn, Wilhelm Winckler
-
Patent number: 4524027Abstract: Membrane-associated proteins, called MP.sub.2, and a process for obtaining them are described. The proteins have the following parameters:(a) an electrophoretic mobility in the range between that of .alpha..sub.2 and that of .beta..sub.1 globulins;(b) an isoelectric point in the pH range 4.4-5.0;(c) a sedimentation coefficient s.sub.20W.sup.c in the range from 7 to above 20 S, the main fractions (IV, III, II and I) sedimenting at about 7, 9, 14 and 20 S respectively;(d) molecular weights in the range from 200,000 to 1,000,000, the main fractions (IV, III, II and I) having molecular weights of about 210,000, 400,000, 750,000 and 1,000,000;(e) an extinction coefficient E.sub.1 cm.sup.1% (280 nm) of 12.5.+-.0.2;(f) a carbohydrate content of 8.0.+-.3.2% (mannose 1.4.+-.0.4%, fucose 0.4.+-.0.2%, galactose 1.2.+-.0.4%, N-acetylglucosamine 2.6.+-.1.8%, and N-acetylneuraminic acid 2.4.+-.1.Type: GrantFiled: September 21, 1984Date of Patent: June 18, 1985Assignee: Behringwerke AktiengesellschaftInventor: Hans Bohn
-
Patent number: 4507229Abstract: The protein PP.sub.4 which has(a) an electrophoretic mobility in the range between that of .alpha..sub.1 and .alpha..sub.2 globulins;(b) an isoelectric point of 4.85.+-.0.15;(c) a sedimentation coefficient s.sub.20,w.sup.0 of 3.3.+-.0.2S;(d) a molecular weight determined in polyacrylamide gel containing sodium dodecylsulfate (DSD) of 35,000.+-.5,000;(e) an extinction coefficient E.sub.1 cm.sup.1% (280 nm) of 5.9.+-.0.6;(f) a carbohydrate content of 2.4.+-.0.94% (g/100 g) (mannose 0.3.+-.0.2%, galactose 0.4.+-.0.2%, xylose 0.1.+-.0.4%, glucose 0.2.+-.0.1%, glucosamine 1.0.+-.0.2% and neuraminic acid 0.4.+-.0.2%) and(g) a specified aminoacid composition, and a process for its preparation are described. PP.sub.4 can be used to prepare antisera which can be employed to detect and determine PP.sub.4 in body fluids in order to diagnose diseases of particular organs, as a "marker" to monitor the progress of a disease or to check therapy.Type: GrantFiled: April 24, 1984Date of Patent: March 26, 1985Assignee: Behringwerke AktiengesellschaftInventor: Hans Bohn
-
Patent number: 4500451Abstract: Protein PP.sub.13 is isolated from human placental tissues using a variety of methods, e.g., immunoadsorption. The protein has utility in production of an antiserum which has diagnostic applications. The placental specific proteins (e.g., PP.sub.13) are frequently detected in increasing amounts in women as pregnancy advances, and in patients with tumors especially of the tryphoblastic and embryonal types.Type: GrantFiled: August 18, 1983Date of Patent: February 19, 1985Assignee: Behringwerke AktiengesellschaftInventors: Hans Bohn, Walter Kraus
-
Patent number: 4468345Abstract: The protein PP.sub.17, which has (a) an electrophoretic mobility in the range between .beta..sub.1 - and .alpha..sub.2 -globulins, (b) an isoelectric point of 5.25.+-.0.20, (c) a sedimentation coefficient S.sub.20.sup.o, w of 2.7.+-.0.1 S, (d) a molecular weight, determined in polyacrylamide gel containing sodium dodecyl sulfate (SDS), of 38,000.+-.2,000, (e) an extinction coefficient E.sub.1cm.sup.1% (280 nm) of 8.5.+-.0.4 and (f) a carbohydrate content of 2.1.+-.0.9% containing 0.3.+-.0.2% of mannose, 0.4.+-.0.2% of galactose, 0.2.+-.0.1% of xylose, 1.0.+-.0.3% of N-acetyl-glucosamine and 0.2.+-.0.1% of N-acetyl-neuramin acid, is described.A process for concentrating and isolating it and its use are also described.Type: GrantFiled: July 29, 1983Date of Patent: August 28, 1984Assignee: Behringwerke AktiengesellschaftInventors: Hans Bohn, Wilhelm Winckler
-
Patent number: 4402872Abstract: What are disclosed are an isolated tissue protein, denominated PP16, which can be used to prepare anti-sera useful as diagnostic agents, said protein being found in extracts of some human organs such as the placenta, spleen, stomach, and lung and being capable of isolation therefrom and which has the following properties:(a) a carbohydrate content of 4.3.+-.1.6%, comprising 3.4.+-.1.2% of hexoses, 0.24.+-.0.07% hexosamines, 0.06.+-.0.03% of fucose, and 0.6.+-.0.3% of neuraminic acid;(b) a sedimentation coefficient S.sub.20,w.sup.0 of 4.6.+-.0.4 S;(c) a molecular weight, determined in a polyacrylamide gel containing sodium dodecyl-sulfate, of 46,000.+-.3,000;(d) an extinction coefficient E.sub.1 cm.sup.1% (280 nm) of 8.82.+-.0.5;(e) an electrophoretic mobility in the range of albumin; and(f) an isoelectric point of 4.7.+-.0.2.Type: GrantFiled: March 11, 1982Date of Patent: September 6, 1983Assignee: Behringwerke AktiengesellschaftInventor: Hans Bohn
-
Patent number: 4392909Abstract: A method and device for producing multilayer printed circuit boards, under the application of heat and pressure to a stack of printed circuit boards and interposed layers of thermosetting plastic, the multilayer stack being heated in a first press to a curing temperature above the flux point of the bonding layers, then precooled under continued pressure to a transfer temperature below the flux point and transferred to a second press, where it is aftercooled under pressure to ambient temperature. The press installation of the invention includes two independently operating multi-stage presses in a common press frame. The plates of the press stages are horizontally aligned in the open position of the two presses.Type: GrantFiled: September 2, 1981Date of Patent: July 12, 1983Assignee: Robert Burkle GmbH & Co.Inventors: Hans Bohn, Wolfgang Stein, Peter Bernsau, Fred Staubitzer
-
Patent number: 4368148Abstract: What are disclosed are a protein, PP.sub.9, useful for the diagnosis and monitoring of diseases involving tissue degradation, and a method for its isolation, said protein having:(a) a content of carbohydrates of 5.57.+-.1.35%, of which are 4.9.+-.1.0% hexoses, 0.1.+-.0.1% hexoseamines, 0.07.+-.0.05% fucose and 0.5.+-.0.20% neuraminic acid;(b) a sedimentation coefficient S.sub.20,W of 3.2.+-.0.2 S;(c) a molecular weight of 35,100.+-.3,800 determined in the ultracentrifuge;(d) a molecular weight of 40,000.+-.4,000 determined in sodium dodecylsulfate (SDS)-containing polyacrylamide gel;(e) an extinction coefficient E.sub.1 cm .sup.1% (280 nm) of 14.6.+-.1.0 ;(f) an electrophoretic mobility in the range of the .beta..sub.1 -globulins; and(g) an isoelectric point in a pH range of 5.0-6.8.Type: GrantFiled: April 8, 1981Date of Patent: January 11, 1983Assignee: Behringwerke AktiengesellschaftInventor: Hans Bohn
-
Patent number: 4367115Abstract: A device for controlling a heated panel press in the switchover from a contact pressure mode to a curing pressure mode, in connection with the assembly of multilayer stacks of printed circuit boards with interposed thermosetting resinous bonding layers, the device consisting essentially of a displacement transducer measuring the decrease in the stack height in terms of displacement pulses and a pulse counter and count comparator producing a switchover signal at a predetermined threshold count which reflects attainment of the flux point in the bonding layer resin. After an adjustable delay, the switchover signal is transmitted to the control unit of the press.Type: GrantFiled: October 13, 1981Date of Patent: January 4, 1983Assignee: Robert Burkle GmbH & Co.Inventors: Hans Bohn, Wolfgang Stein, Peter Bernsau, Fred Staubitzer
-
Patent number: 4348316Abstract: What are disclosed are a protein, PP.sub.15, useful for preparing antisera and as an immunosuppressive agent, and a method for isolating the pure protein from human placentas.Type: GrantFiled: December 29, 1980Date of Patent: September 7, 1982Assignee: Behringwerke AktiengesellschaftInventor: Hans Bohn
-
Patent number: 4325866Abstract: What are disclosed are a new protein, PP.sub.11, obtainable from placental tissue, methods for isolating the protein in concentrated form, methods for making an antiserum to said protein, and methods for using said antiserum for monitoring pregnancy and for detecting and monitoring tumors and/or their therapy.Type: GrantFiled: November 14, 1980Date of Patent: April 20, 1982Assignee: Behringwerke AktiengesellschaftInventor: Hans Bohn
-
Patent number: 4302385Abstract: A new placenta-specific protein (PP.sub.10) and a process for isolating it are described.Type: GrantFiled: December 17, 1979Date of Patent: November 24, 1981Assignee: Behringwerke AktiengesellschaftInventors: Hans Bohn, Walter Kraus
-
Patent number: 4301064Abstract: A new soluble tissue protein (PP.sub.8) and a process for isolating it from human organs is described. The protein has antigenic properties. In the case of diseases which involve tissue disintegration its presence in the blood in increased concentration can be established.Type: GrantFiled: September 27, 1979Date of Patent: November 17, 1981Assignee: Behringwerke AktiengesellschaftInventor: Hans Bohn
-
Patent number: 4297343Abstract: What are disclosed are methods for the prevention of pregnancy, or the interruption of pregnancy, in primates by the parenteral administration of a substance which immunologically reacts with the protein PP.sub.5 or induces immunologically reactive substances directed against PP.sub.5 and pharmaceutical preparations containing such a substance.Type: GrantFiled: May 16, 1980Date of Patent: October 27, 1981Assignee: Behringwerke AktiengesellschaftInventors: Hans Bohn, Ernst Weinmann
-
Patent number: 4297274Abstract: The invention relates to a new protein which can be immunologically proved in the lysate of human erythrocytes and isolated therefrom and which has the following properties:a protein proportion of 99%.+-.1%, preponderantly consisting of .alpha.-amino-acids,a carbohydrate proportion of 0.9%.+-.0.5%,a sedimentation coefficient of S.sub.20 w.sup.C.dbd.O of 6.88.+-.0.50 S,a molecular weight of 160,000.+-.15,000,an iso-electric point of 5.5.+-.0.2,an electrophoretic mobility in the range of the .beta..sub.1 -globulins of the human serum, anda specific immunological reaction with an antibody directed specifically against the protein;and a process for isolating it. The new protein is suitable as diagnostic agent and for the preparation of antisera.Type: GrantFiled: March 7, 1980Date of Patent: October 27, 1981Assignee: Behringwerke AktiengesellschaftInventors: Hans Bohn, Heinz Haupt