Patents by Inventor Hans Bräuner-Osborne

Hans Bräuner-Osborne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POSITIVE ALLOSTERIC MODULATORS OF THE CALCIUM-SENSING RECEPTOR
    Publication number: 20220411495
    Abstract: The present invention relates to non-naturally occurring antibodies or active antibody fragments specifically binding the calcium-sensing receptor (CaSR), acting as positive allosteric modulators (PAMs) to provide for potent therapeutic agents. More particular, the immunoglobulin single variable domains (ISVDs) identified herein reveal a novel therapeutic strategy to reduce parathyroid hormone release in a subject, and are therefore suitable for treatment of hypercalcemia disorders. Moreover, co-application of such an ISVD and a synthetic PAM or calcimimetic results in a synergistic agonistic CaSR activity providing for pharmaceutical compositions as next generation CaSR drugs.
    Type: Application
    Filed: November 27, 2020
    Publication date: December 29, 2022
    Inventors: Jan Steyaert, Els Pardon, Alexandre Wohlkönig, Thomas Zögg, Iris Mos, Hans Bräuner-Osborne, Jesper Mosolff Mathiesen
  • ALLOSTERIC ANTAGONISTS OF GPRC6a AND THEIR USE IN MITIGATING PROTEINOPATHIES
    Publication number: 20190358238
    Abstract: Disclosed herein are compounds and methods for antagonizing GPRC6a for the treatment of proteinopathies.
    Type: Application
    Filed: November 16, 2017
    Publication date: November 28, 2019
    Inventors: Daniel Carl Lee, Daniel Sejer Pedersen, Hans Bräuner-Osborne, David Erik Gloriam, Sebastiaan Kuhne, Henrik Karl Johansson