Abstract: A robotic surgical system includes an instrument cart having a setup arm assembly and a control drive assembly coupled to the setup arm assembly. The control drive assembly includes a chassis assembly, a first drive unit and a second drive unit mounted to the chassis assembly, and a leadscrew assembly. Each drive unit is positioned to translate relative to the chassis assembly between a retracted position and an advanced position. The first drive unit couples to a first surgical instrument and the second drive unit couples to a second surgical instrument. The leadscrew assembly is mounted to the chassis assembly and includes a first leadscrew operably associated with the first drive unit and a second leadscrew operably associated with the second drive unit. The first leadscrew rotates to cause the first drive unit to translate relative to the chassis assembly. The second leadscrew rotates to cause the second drive unit to translate relative to the chassis assembly.

Abstract: The present invention relates to methods for treating or preventing chronic kidney disease and cardiovascular disease in patients with chronic kidney disease comprising administering empagliflozin to the patient.

Abstract: pa The method of processing a semiconductor wafer includes forming one or more epitaxial layers over its first main surface. It also involves forming one or more porous layers within the semiconductor wafer or within the epitaxial layers. Together, the semiconductor wafer, the epitaxial layer(s), and the porous layer(s) form a substrate. Next, doped regions of a semiconductor device are formed within the epitaxial layer(s). After forming these doped regions, a non-porous part of the semiconductor wafer is separated from the rest of the substrate along the porous layer(s).

Abstract: A resonant DC converter is equipped with a supply input for a supply voltage, a DC voltage output for providing a DC voltage, a pulse generator connected to the supply input, a resonant converter connected to outputs of the pulse generator and on the output side to the DC voltage output, a capacitor connected between positive and negative poles of the DC voltage output, and a controller. The pulse generator generates pulses at a pulse frequency specified by the controller and to output them to the resonant converter. The resonant converter has a plurality N of resonant tanks having a resonant frequency. The controller is configured to specify a first pulse frequency to the pulse generator during an initialization time period of the DC converter and to specify a second pulse frequency different from the first pulse frequency to the pulse generator during a continuous operation time period.

Abstract: The present invention relates to methods for preventing or treating acute or chronic heart failure and for reducing the risk of cardiovascular death, hospitalization for heart failure and other conditions in patients with preserved or reduced ejection fraction by administering empagliflozin to the patient.

Abstract: A method of complementing a map of a scene with 3D reference points including four steps. In a first step, data is collected and recorded based on samples of at least one of an optical sensor, a GNSS, and an IMU. A second step includes initial pose generation by processing of the collected sensor data to provide a track of vehicle poses. A pose is based on a specific data set, on at least one data set recoded before that dataset and on at least one data set recorded after that data set. A third step includes SLAM processing of the initial poses and collected optical sensor data to generate keyframes with feature points. In a fourth step 3D reference points are generated by fusion and optimization of the feature points by using future and past feature points together with a feature point at a point of processing. This second and fourth steps provides significantly better results than SLAM or VIO methods known from prior art, as the second and the fourth steps are based on recorded data.

Abstract: The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.

Abstract: The invention provides a means for a treatment for a demyelinating disease of the central nervous system (CNS) characterized by the presence of an anti-myelin oligodendrocyte glycoprotein (MOG) antibody, and also for reducing the risk of relapse in the demyelinating disease, comprising an anti-IL-6 receptor antibody or antigen binding fragment thereof.

Abstract: A sliding bearing component (100) for an application device (250) of a disc brake (220) for a vehicle (200a), in particular a commercial vehicle (200b), has a lateral surface (110) with a cross section (115) that is in the form of a full circle in some section or sections. The sliding bearing component (100) has a limiting element (120) arranged on the lateral surface for limiting a displaceability of the sliding bearing component (100). A brake caliper (150) includes a pedestal section (155) with a recess (160) arranged to cooperate with the sliding bearing component (100). The pedestal section has a limiting element (165) arranged to receive the limiting element (120) of the sliding bearing component (100). The recess (160) is at least partly cylindrical in a section or sections and/or is defined by two planes.

Abstract: The techniques disclosed herein enable systems to safely deploy a plurality of upgrade variants to different resource units that provide a service by utilizing small-scale deployment and validation. To deploy upgrade variants, a system receives a selection of upgrade variants from a feature group and automatically selects an appropriate set of resource units at which to deploy the upgrade variants. The system is further configured to collect and analyze telemetry data from the set of resource units to determine if any problems have occurred as a result of the deployed upgrade variants. By analyzing the telemetry data, the system can also identify one or more upgrade variants that are causing the problems. In response, the system can remove the identified variants and proceed with deployment of the remaining upgrade variants.

Abstract: A dental machining system for manufacturing a dental restoration including: a dental tool machine (1) which has: a dental blank holder for holding at least one dental blank (2) relatively movably with respect to one or more dental tools (3); one or more driving units (4) each for movably holding at least one dental tool (3) for machining the dental blank (2), a control unit for controlling the dental blank holder and the driving units (4) based at least on a temporal trajectory of the dental tool (3) relative to the dental blank (2) and a spatial amount of material removal from the dental blank (2) along the temporal trajectory. The control unit executes a trained artificial intelligence algorithm.

Abstract: A method, an apparatus, and a storage medium for detecting vulnerabilities in software to protect a computer system from security and compliance breaches are provided. The method includes providing a ruleset code declaring programming interfaces of a target framework and including rules that define an admissible execution context when invoking the programming interfaces, providing a source code to be scanned for vulnerabilities; compiling the source code into a first execution code having additional instructions inserted to facilitate tracking of an actual execution context of the source code, compiling the ruleset code into a second execution code that can be executed together with the first execution code, executing the first execution code within an virtual machine and passing calls of the programming interfaces to the second execution code, and detecting a software vulnerability when the actual execution context disagrees with the admissible execution context.

Abstract: The invention relates to a human recombinant monoclonal antibody or antibody fragment that binds the receptor binding domain (RBD) of the S1 subunit (S1) of a Spike glycoprotein of SARS-CoV-2, wherein the heavy and light chain variable amino acid sequences of the antibody (VH and VL) were isolated from convalescent COVID-19 patients. In further aspects, the invention relates to a nucleic acid molecule encoding an antibody or antibody fragment of the invention, a host cell comprising the nucleic acid molecule, and a pharmaceutical composition comprising an antibody or antibody fragment of the invention. The invention further relates to corresponding medical uses and therapeutic methods of administering an antibody or antibody fragment of the invention in the treatment and/or prevention of a medical condition associated with a SARS Coronavirus, in addition to diagnostic uses and methods.

Abstract: Ozone generator (1) for generating ozone comprising at least one high voltage electrode HVE (2), two low voltage electrodes LVE (3), at least one dielectric (4) and an electric isolator (25) placed in an area between the two LVE (3?, 3?). The generator (1) further comprises a first gap (7) and a second gap (8) and at least one of the gaps (7, 8) is a corona chamber. The at least one dielectric (4) comprising a first surface (9) is turning towards a HVE-surface (22) and an opposite second surface (10) is turning towards a first surface (17) of one of the LVE (3). The second surface (10) of the dielectric (4) is directly or indirectly supported in its full extension by the first LVE-surface (17), and at least one of the gaps (7, 8) is placed between the first surface (9) of the dielectric (4) and a first HVE-surface (22), said gap is a corona-chamber adapted to develop ozone.

Abstract: A polyolester mixture as substitute for vaseline obtainable by esterification reaction of a) 0.8 to 1.2 mol glycerin b) 0.5 to 0.7 mol sebacic acid c) 1.0 to 1.4 mol of a monocarboxylic fatty acid mixture with a chain length of 8 to 24 carbon atoms characterized in that the fatty acid mixture c) comprises at maximum 30 wt % of a linear C18 fatty acid, at maximum 3 wt % of fatty acids lower than C12 and at maximum 3 wt % of fatty acids higher than C18 based on the weight of the sum of monocarboxylic fatty acids.

Abstract: A surgical system includes a drive assembly and a dexterous endoscope. The endoscope defines a longitudinal axis and is actuatable by the drive assembly. The endoscope includes a camera assembly and an articulation assembly. The articulation assembly supports the camera assembly and is actuatable to move the camera assembly relative to the longitudinal axis. The distal wrist assembly includes links that are movable relative to one another, and the proximal wrist assembly includes links that are movable relative to one another.

Abstract: The present teachings relate to a method for transforming a digital 3D dental model to a 2D dental image, the method including: providing, at least two selected images from the 3D dental model; converting, each of the selected images, to a respective color component of a color model; obtaining, by combining the respective color components, the 2D image in a computer-readable format of the color model. The present teachings also relate to a method of classification of the 2D image, a dental procedure assisting system, uses and computer software products.

Abstract: The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.

Abstract: In order to avoid complex electronic synchronization of various supply modules of an entire supply unit engaging on a caliber, the individual supply modules do not have separate drives, but rather a supply drive, usually a controllable electric motor, is mechanically operatively connected to several, preferably all existing, supply modules. As a result, moveable parts of the supply modules, which effect transport of the caliber in a supply direction, are driven accordingly.

Abstract: The invention relates to a method for reliquefying boil-off gas (BOG) containing volatile components, the method comprising the following steps: a) compressing a BOG stream, wherein the BOG stream exits a final compression stage as a finally compressed BOG stream having a final pressure; b) condensing the finally compressed BOG stream to obtain an at least partly condensed, finally compressed fluid stream; c) providing a fluid receptacle having a fluid stream inlet and a fluid stream outlet, wherein the position of the fluid stream outlet is selected such that it is above a predefined fluid containment volume; d) feeding the fluid stream from step b) through the fluid stream inlet into the fluid receptacle; e) setting a liquid level setpoint for the fluid receptacle such that the liquid level setpoint is at the level of the upper edge of the fluid stream outlet or a predefined amount above it; f) setting an upper final pressure limit for the final compression stage; g) measuring the liquid level in the fluid