Patents by Inventor Hans-Christian Kliem

Hans-Christian Kliem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LIGANDS COMPRISING AN AMYLASE CLEAVABLE LINKER
    Publication number: 20220324898
    Abstract: In particular, the present invention relates to a PSMA binding ligand comprising an oligosaccharide building block which comprises a bond being cleavable by alpha-amylase. Typically, this PSMA binding ligand further comprises a PSMA binding motif Q and a chelator residue A, wherein the PSMA binding motif Q and the chelator residue A are preferably linked via at least one linker LAQ comprising the oligosaccharide building block, the PSMA binding ligand thus preferably having the structure (I) A-LAQ-Q or a pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: February 14, 2020
    Publication date: October 13, 2022
    Inventors: Matthias Eder, klaus Kopka, Martin Schäfer, Ulrike Bauder-Wuest, Uwe Haberkrn, Hans-Christian Kliem, Walter Mier, Thomas Lindner
  • Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
    Patent number: 10471160
    Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: November 12, 2019
    Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
    Inventors: Matthias Eder, Klaus Kopka, Martin Schäfer, Ulrike Bauder-Wüst, Uwe Haberkorn, Michael Eisenhut, Walter Mier, Martina Benesova, Hans-Christian Kliem, Clemens Kratochwil
  • LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), THEIR USE AS IMAGING AGENTS AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF PROSTATE CANCER
    Publication number: 20190008988
    Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
    Type: Application
    Filed: July 18, 2018
    Publication date: January 10, 2019
    Inventors: Matthias EDER, Klaus KOPKA, Martin SCHÄFER, Ulrike BAUDER-WÜST, Uwe HABERKORN, Michael EISENHUT, Walter MIER, Martina BENESOVA, Hans-Christian KLIEM, Clemens KRATOCHWIL
  • DIMEDON DERIVATIVE AND A METHOD FOR THE PURIFICATION OF PNA AND PEPTIDE OLIGOMERS
    Publication number: 20130274440
    Abstract: The present invention concerns a new dimedon derivative and a method for the purification of PNA and peptide oligomers.
    Type: Application
    Filed: April 8, 2013
    Publication date: October 17, 2013
    Inventors: Anette JACOB, Jörg HOHEISEL, Marc DAUBER, Manfred WIESSLER, Peter LORENZ, Heinz FLEISCHHACKER, Hans-Christian KLIEM
  • Method for producing water-soluble saccharide conjugates and saccharide mimetics by Diels-Alder reaction
    Patent number: 6958395
    Abstract: The present invention relates to a method by which saccharide compounds can be prepared in a very easy way. This method comprises the steps of: (a) attaching at least one saccharide to a cyclic or acyclic diene, (b) reacting the saccharide-containing diene obtained in step (a) or a commercially available saccharide-containing diene with a dienophile by Diels-Alder reaction.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: October 25, 2005
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Manfred Wiessler, Hans-Christian Kliem, Bernd Sauerbrei, Birgit Schmauser
  • Method for producing water-soluble saccharide conjugates and saccharide mimetics by diels-alder reaction
    Publication number: 20040059101
    Abstract: The present invention relates to a method by which saccharide compounds can be prepared in a very easy way.
    Type: Application
    Filed: September 8, 2003
    Publication date: March 25, 2004
    Inventors: Manfred Weissler, Hans-Christian Kliem, Bernd Sauerbrei, Birgit Schmauser