Patents by Inventor Hans E. Holtan
Hans E. Holtan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10677785Abstract: The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a DNA sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the DNA sequence-specific transactivator. The target promoter sequence can be recognized by a transcriptional regulatory polypeptide capable of modulating specific signaling pathways that enhance plant performance or yield.Type: GrantFiled: April 13, 2016Date of Patent: June 9, 2020Assignee: Plant Response, Inc.Inventors: Joshua I. Armstrong, Hans E. Holtan, Masa-aki Ohto, Adina M. Bailey, Robert A. Creelman
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Publication number: 20200010844Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.Type: ApplicationFiled: July 16, 2019Publication date: January 9, 2020Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen
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Patent number: 10407689Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.Type: GrantFiled: August 7, 2017Date of Patent: September 10, 2019Assignee: Mendel Biotechnology, Inc.Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen
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Patent number: 10385356Abstract: This disclosure provides transgenic plants, including crop plants and methods for their production. The transgenic plants comprise recombinant DNA constructs for the expression of polypeptides encoded by the DNA constructs. The polypeptides are capable of conferring improved traits to the transgenic plants when expressed under the control of a tissue-enhanced promoter. This disclosure also pertains to transgenic plants and their progeny plants, wherein the transgenic or progeny plants comprise the recombinant DNA constructs and are selected for having enhanced nitrogen use efficiency and/or nitrogen uptake. Seed of the transgenic plants that can be grown into a plant that comprise the disclosed recombinant DNA constructs and exhibits having enhanced nitrogen use efficiency, and which may be selected for this trait, are also envisioned.Type: GrantFiled: November 13, 2018Date of Patent: August 20, 2019Assignee: KOCH BIOLOGICAL SOLUTIONS, LLCInventors: Robert A. Creelman, Suqin Cai, Hans E. Holtan, T. Lynne Reuber, Oliver J. Ratcliffe
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Patent number: 10316325Abstract: This disclosure provides transgenic plants, including crop plants and methods for their production. The transgenic plants comprise recombinant DNA constructs for the expression of polypeptides encoded by the DNA constructs. The polypeptides are capable of conferring improved traits to the transgenic plants when expressed under the control of a tissue-enhanced promoter. This disclosure also pertains to transgenic plants and their progeny plants, wherein the transgenic or progeny plants comprise the recombinant DNA constructs and are selected for having enhanced nitrogen use efficiency and/or nitrogen uptake. Seed of the transgenic plants that can be grown into a plant that comprise the disclosed recombinant DNA constructs and exhibits having enhanced nitrogen use efficiency, and which may be selected for this trait, are also envisioned.Type: GrantFiled: March 11, 2015Date of Patent: June 11, 2019Assignee: Koch Biological Solutions, LLCInventors: Robert A. Creelman, Suqin Cai, Hans E. Holtan, T. Lynne Reuber, Oliver J. Ratcliffe
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Patent number: 10155956Abstract: This disclosure provides transgenic plants, including crop plants and methods for their production. The transgenic plants comprise recombinant DNA constructs for the expression of polypeptides encoded by the DNA constructs. The polypeptides are capable of conferring improved traits to the transgenic plants when expressed under the control of a tissue-enhanced promoter. This disclosure also pertains to transgenic plants and their progeny plants, wherein the transgenic or progeny plants comprise the recombinant DNA constructs and are selected for having enhanced nitrogen use efficiency and/or nitrogen uptake. Seed of the transgenic plants that can be grown into a plant that comprise the disclosed recombinant DNA constructs and exhibits having enhanced nitrogen use efficiency, and which may be selected for this trait, are also envisioned.Type: GrantFiled: July 10, 2018Date of Patent: December 18, 2018Assignee: KOCH BIOLOGICAL SOLUTIONS, LLCInventors: Robert A. Creelman, Suqin Cai, Hans E. Holtan, T. Lynne Reuber, Oliver J. Ratcliffe
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Patent number: 10047372Abstract: This disclosure provides transgenic plants, including crop plants and methods for their production. The transgenic plants comprise recombinant DNA constructs for the expression of polypeptides encoded by the DNA constructs. The polypeptides are capable of conferring improved traits to the transgenic plants when expressed under the control of a tissue-enhanced promoter. This disclosure also pertains to transgenic plants and their progeny plants, wherein the transgenic or progeny plants comprise the recombinant DNA constructs and are selected for having enhanced nitrogen use efficiency and/or nitrogen uptake. Seed of the transgenic plants that can be grown into a plant that comprise the disclosed recombinant DNA constructs and exhibits having enhanced nitrogen use efficiency, and which may be selected for this trait, are also envisioned.Type: GrantFiled: March 11, 2015Date of Patent: August 14, 2018Assignee: Koch Biological Solutions, LLCInventors: Robert A. Creelman, Suqin Cai, Hans E. Holtan, T. Lynne Reuber, Oliver J. Ratcliffe
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Publication number: 20180087067Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.Type: ApplicationFiled: August 7, 2017Publication date: March 29, 2018Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen
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Patent number: 9758791Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.Type: GrantFiled: April 8, 2013Date of Patent: September 12, 2017Assignee: Mendel Biotechnology, Inc.Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen
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Publication number: 20160349243Abstract: The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a DNA sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the DNA sequence-specific transactivator. The target promoter sequence can be recognized by a transcriptional regulatory polypeptide capable of modulating specific signaling pathways that enhance plant performance or yield.Type: ApplicationFiled: April 13, 2016Publication date: December 1, 2016Applicant: Koch Biological Solutions, LLCInventors: Joshua I. Armstrong, Hans E. Holtan, Masa-aki Ohto, Adina M. Bailey, Robert A. Creelman
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Publication number: 20160201146Abstract: The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a DNA sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the DNA sequence-specific transactivator. The target promoter sequence can be recognized by a transcriptional regulatory polypeptide capable of modulating specific signaling pathways that enhance plant performance or yield.Type: ApplicationFiled: March 30, 2016Publication date: July 14, 2016Applicant: Koch Biological Solutions, LLCInventors: Joshua I. Armstrong, Hans E. Holtan, Masa-aki Ohto, Adina M. Bailey
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Patent number: 9322070Abstract: The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a DNA sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the DNA sequence-specific transactivator. The target promoter sequence can be recognized by a transcriptional regulatory polypeptide capable of modulating specific signaling pathways that enhance plant performance or yield.Type: GrantFiled: May 23, 2011Date of Patent: April 26, 2016Assignee: Koch Biological Solutions, LLCInventors: Joshua I. Armstrong, Hans E. Holtan, Masa-aki Ohto, Adina M. Bailey
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Publication number: 20150052633Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.Type: ApplicationFiled: April 8, 2013Publication date: February 19, 2015Applicant: Mendel Biotechnology, Inc.Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen
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Patent number: 8895305Abstract: Water deficit-inducible promoter sequences were identified that may be used to produce transgenic plants that are more tolerant to water deficit and related hyperosmotic stresses than control plants, and yet are wild-type or nearly wild type in appearance. Any of these water deficit-inducible promoters may be incorporated into an expression vector that comprises a polynucleotide regulated by one such promoter and which encodes a polypeptide that, when ectopically expressed, improves water deficit tolerance in plants that are similar to control plants in their morphology and development.Type: GrantFiled: February 7, 2008Date of Patent: November 25, 2014Assignee: Mendel Biotechnology, Inc.Inventors: Peter P. Repetti, Hans E. Holtan, Roderick W. Kumimoto, Oliver J. Ratcliffe
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Publication number: 20130198901Abstract: The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve performance.Type: ApplicationFiled: May 23, 2011Publication date: August 1, 2013Applicant: MENDEL BIOTECHNOLOGY, INC.Inventors: Joshua I. Armstrong, Hans E. Holtan, Masa-aki Ohto, Adina M. Bailey
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Publication number: 20120131691Abstract: Light-regulated promoter sequences were identified that respond to differential light conditions and so can be used to regulate gene expression in a light- or dark-inducible manner. These promoters may be used to produce transgenic plants that have an altered trait relative to control plants. In preferred embodiments, the transgenic plants with the improved traits are morphologically and/or developmentally similar to control plants (examples of the latter include wild-type or non-transformed plants of the same species). Any of these light-regulated promoters may be incorporated into a nucleic acid construct that comprises a polynucleotide regulated by one such promoter and that encodes a polypeptide or RNA molecule that, when ectopically expressed, confers an improved trait in plants.Type: ApplicationFiled: May 17, 2010Publication date: May 24, 2012Applicant: Mendel Biotechnology, Inc.Inventors: Peter P. Repetti, Rajnish Khanna, Hans E. Holtan, T. Lynne Reuber, Oliver J. Ratcliffe
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Publication number: 20110179520Abstract: Tissue-enhanced promoter sequences were identified that enhance expression of a polypeptide in one or more plant tissues. These promoters may be used to produce transgenic plants that have an altered trait relative to control plants. In preferred embodiments, the transgenic plants with the improved traits are morphologically and/or developmentally similar to control plants (examples of the latter include wild-type or non-transformed plants of the same species). Any of these tissue-enhanced promoters may be incorporated into a nucleic acid construct that comprises a polynucleotide regulated by one such promoter and that encodes a polypeptide or RNA molecule that, when ectopically expressed, confers an improved trait in plants.Type: ApplicationFiled: January 19, 2011Publication date: July 21, 2011Applicant: Mendel Biotechnology, Inc.Inventors: Suqin CAI, Hans E. Holtan, Peter P. Repetti, T. Lynne Reuber
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Publication number: 20110010796Abstract: Water deficit-inducible promoter sequences were identified that may be used to produce transgenic plants that are more tolerant to water deficit and related hyperosmotic stresses than control plants, and yet are wild-type or nearly wild type in appearance. Any of these water deficit-inducible promoters may be incorporated into an expression vector that comprises a polynucleotide regulated by one such promoter and which encodes a polypeptide that, when ectopically expressed, improves water deficit tolerance in plants that are similar to control plants in their morphology and development.Type: ApplicationFiled: February 7, 2008Publication date: January 13, 2011Applicant: Mendel Biotechnology, Inc.Inventors: Peter P. Repetti, Hans E. Holtan, Roderick W. Kumimoto, Oliver J. Ratcliffe
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Publication number: 20100071086Abstract: In this invention, a method is described that allows for the efficient creation and identification of validated biological materials that greatly enhance the ability to perform polysome-mediated RNA profiling, such as constitutive, cell type-, tissue type-, or condition-enhanced RNA profiling. The method relies on the use of a tri-partite plant binary expression vector comprised of the following components: a) a DNA promoter element that drives expression of a sequence specific transcription activator protein such as a LexA:Gal4 fusion protein in a unique desired pattern, b) a DNA promoter element comprising a target site for the transcriptional activator protein, such as opLexA, fused to a nucleotide encoding an epitope tagged ribosomal component protein and c) a DNA promoter element comprising a target site for the transcriptional activator protein, such as opLexA, fused to a nucleotide encoding an in vivo reporter protein.Type: ApplicationFiled: September 10, 2009Publication date: March 18, 2010Applicant: MENDEL BIOTECHNOLOGY, INC.Inventors: Peter P. Repetti, Oliver J. Ratcliffe, Luc J. Adam, T. Lynne Reuber, Hans E. Holtan