Patents by Inventor Hans E. P. Strom

Hans E. P. Strom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5300660
    Abstract: Stereoconservative method for preparation of an (R)- or (S)-isomer of the compound of the formula I with at least 95% optical purity ##STR1## wherein R.sup.1 is a hydrogen atom, a saturated or unsaturated lower alkyl group, a cycloalkyl group, or a group (CH.sub.2).sub.m Ph wherein m is 0-3 and Ph is a substituted or unsubstituted phenyl group including1) O,N-dialkylation, directly or stepwise of (R)- or (S)-proline2) aminolysis3) reduction to formation of the (R)- or (S)-isomer of the compound of the formula I, and new intermediates II and III in optical active form obtained by the reaction steps above and wherein R.sup.2 is defined as R.sup.1 above.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: April 5, 1994
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Hans-Jurgen Federsel, Thomas Hogberg, Sten I. Ramsby, Hans E. P. Strom
  • Patent number: 5240957
    Abstract: Novel therapeutically active compounds of the formula ##STR1## wherein Z.sup.i, being Z.sup.1, Z.sup.2 or Z.sup.3, is the same or different and selected among OH, OR.sup.1, NH.sub.2, NR.sub.2.sup.4, NHR.sup.4, SH, SR.sup.4 and OR.sup.4 wherein R.sup.1 is a formyl group, an acyl group, an alkoxycarbonyl group or a mono- or dialkylcarbamoyl group and R.sup.4 is a lower alkyl group,R.sup.2 is a hydrogen, a halogen, a lower alkyl or a lower trifluoroalkyl group,R.sup.3 is a hydrogen atom, a lower alkyl group, an alkenyl group, an alkynyl group or a phenyl group, which phenyl group could optionally be substituted by one or more of fluoro, chloro, bromo, trifluoromethyl, methyl, ethyl, methoxy or ethoxy in the ortho, meta or para positions, or optionally substituted by methylenedioxy, provided that at least one of Z.sup.1, Z.sup.2 and Z.sup.3 is a group OR.sup.4 and further provided that when Z.sup.2 is OH or NH.sub.2, Z.sup.1 is NR.sub.2.sup.4, NHR.sup.4, SH, SR.sup.4 or OR.sup.
    Type: Grant
    Filed: October 29, 1990
    Date of Patent: August 31, 1993
    Assignee: Astra Lakemedel Akteibolag
    Inventors: Karl S. Bengtsson, Thomas Hogberg, Lars G. Johansson, Tomas DePaulis, Hans E. P. Strom, Marianne E. Widman, Sven O. gren