Patents by Inventor Hans-Eckart Radunz
Hans-Eckart Radunz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20090297613Abstract: The present invention is directed to a method of producing nanoparticles by the miniemulsion method, said nanoparticles being made by adding a defined amount of stabilizer to the reaction system. The present invention is further directed to nanoparticles made by this method and their use for the treatment of diseases and conditions, requiring a pharmaceutical agent to cross one or more physiological barriers, in particular the blood-brain barrier.Type: ApplicationFiled: February 2, 2007Publication date: December 3, 2009Inventors: Kerstin Ringe, Hans-Eckart Radunz, Julia Kubasch
-
Publication number: 20070292524Abstract: The present invention is directed to a delivery vehicle containing nanoparticles. The present invention is further directed to a pharmaceutical composition, comprising said drug delivery vehicle. Further, the invention pertains to a method for manufacturing of said delivery vehicles as well as to the use of these vehicles in medicine.Type: ApplicationFiled: March 14, 2007Publication date: December 20, 2007Inventors: Kerstin Ringe, Hans-Eckart Radunz, Katharina Landfester, Clemens Weiss
-
Patent number: 5508390Abstract: Diterpenes of the formula I ##STR1## in which R.sup.1 is --CH.sub.2 --C(CH.sub.3).dbd.CH--R.sup.3 or --CH.sub.2 --CH(CH.sub.3)--CH.sub.2 --R.sup.3,R.sup.3 is --CH.sub.2 OH, --CHO, --COOH or --COOR.sup.4,R.sup.4 is alkyl having 1 to 5 C atoms,A is ##STR2## and R.sup.2 is H, pentoses, hexoses, di-/oligosaccharides or amino sugars,are suitable for production of medicaments having immunomodulatory action, in particular stimulating T-cells.Type: GrantFiled: February 15, 1991Date of Patent: April 16, 1996Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Hans-Eckart Radunz, Michael Wolf, Manfred Baumgarth, Willy Kinzy, Gerd-Albrecht Luckenbach
-
Patent number: 5095114Abstract: The invention relates to a process for the enantiomer-selective preparation of .gamma.-keto-.delta.-amino acid derivatives of the formula I ##STR1## characterized in that a compound of the formula II ##STR2## is converted, using a trialkylchlorosilane, into a compound of the formula III ##STR3## this compound is then reacted with a diazoacetate of the formula N.sub.2 CH.sub.2 COOR.sup.4 (R.sup.4 .noteq.H) to give a cyclopropane compound of the formula IV ##STR4## and then the compound IV is converted, by ring-opening and removal of the silyl groups, and where appropriate saponification, into the compound of the formula I, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 having the meanings indicated in claim 1.Type: GrantFiled: June 19, 1990Date of Patent: March 10, 1992Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Hans-Eckart Radunz, Hans U. Reissig
-
Patent number: 5026642Abstract: In a process for the reduction of ketones, the keto compounds are enantioselectively reduced to give secondary alcohols by means of microorganisms. Keto compounds of the formulaR.sup.3 NH--CHR.sup.1 --CO--CH.sub.2 --COOR.sup.2in which R.sup.1, R.sup.2 and R.sup.3 have the meanings defined herein are used as starting compounds.Type: GrantFiled: July 22, 1988Date of Patent: June 25, 1991Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Hans-Eckart Radunz, Harry Schwartz, Martin Heinrich
-
Patent number: 4987133Abstract: New salicylic acid derivatives of the general formula I ##STR1## in which R.sup.1 is H or CH.sub.3,R.sup.2 is 4-(4-methyl-2-thiazolyl)-piperazino, 4-(tetrahydro-2-furoyl)-piperazino, 4-(4-methyl-2-thiazolyl)-homopiperazino, 4-benzamidopiperidino, 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolino, 1-imidazolyl, tribromo-1-imidazolyl or 2-(3-indolyl-1,1-dimethyl-ethylamino andR.sup.3 is alkoxy having 1-C atoms, NH.sub.2 or alkylamino having 1-4 C atoms,as well as the physiologically acceptable acid addition salts thereof, exhibit effects on the circulation, especially effects lowering the blood pressure and relieving the heart, and diuretic effects.Type: GrantFiled: April 17, 1989Date of Patent: January 22, 1991Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Hans-Adolf Kurmeier, Wolf-Dietrich Weber, Hans-Eckart Radunz, Hans-Jochen Schliep
-
Patent number: 4755592Abstract: New peptides of the formula IX--Z--W--E--W'--Y Iwherein X, Z, W, E, W' and Y are as defined herein and their salts inhibit the activity of human plasma renin.Type: GrantFiled: April 3, 1986Date of Patent: July 5, 1988Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Peter Raddatz, Gunter Holzemann, Alfred Jonczyk, Claus J. Schmitges, Klaus-Otto Minck, Hans-Eckart Radunz, Johannes Sombroek
-
Patent number: 4733011Abstract: Compounds of the formula ##STR1## wherein A is C--C single bond, --CH.sub.2 --, --CH(CH.sub.3)--, --C(CH.sub.3).sub.2 --, --CH.sub.2 --CH.sub.2 --, CH(CH.sub.3)CH.sub.2 --, --C(CH.sub.3).sub.2 CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 -- or --CH.sub.2 O--; R.sup.1a and R.sup.1 each independently is hydrogen or a protective group which can be cleaved by solvolysis or by hydrogenolysis; R.sup.2 is H or alkyl of 1 to 3 C atoms; R.sup.3 is alkyl of 3 to 5 C atoms, phenyl or phenyl which is monosubstituted to trisubstituted by F, Cl, OH, OCH.sub.3, OC.sub.2 H.sub.5, CF.sub.3 or alkyl of 1 to 3 C atoms, or, when A is not --CH.sub.2 O--, can also be pyridyl, thienyl, naphthyl or alkoxy of 1 to 4 C atoms; indicates a bond in the .beta.-position and wavy line ( ) means that the bond can be in the .alpha.- or .beta.-position, are valuable intermediates for the stereospecific preparation of 13-thiaprostaglandin derivatives. The latter are prepared by U.V.Type: GrantFiled: August 19, 1985Date of Patent: March 22, 1988Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Bernhard Riefling, Hans-Eckart Radunz
-
Patent number: 4680288Abstract: Sulfur-containing 6-ketoprostaglandins of the formula I ##STR1## in which D is a bond, alkylene having 1-3 C atoms, cis-alkenylene having 2-5 C atoms or alkinylene having 2-5 C atoms,R.sup.1 is H, alkyl having 1-4 C atoms, aryl having 6-12 C atoms or --C.sub.6 H.sub.4 NHCOC.sub.6 H.sub.5,R.sup.2 is alkyl having 1-7 C atoms, alkyl having 1-7 C atoms which is substituted by halogen, cycloalkyl having 5-6 C atoms, cycloalkyl having 5-6 C atoms which is substituted by alkyl having 1-4 C atoms, phenyl, phenyl which is substituted by F, Cl, Br, alkyl having 1-4 C atoms, OH, OCH.sub.3 or CF.sub.3, pyridyl, naphthyl, thienyl or, if D is alkylene having 1-3 C atoms, also is alkoxy having 1-4 C atoms, alkylthio having 1-4 C atoms, phenoxy or phenoxy which is substituted by F, Cl, Br, alkyl having 1-4 C atoms, OH, OCH.sub.3 or CF.sub.3,R.sup.3 and R.sup.Type: GrantFiled: January 18, 1985Date of Patent: July 14, 1987Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Klaus Irmscher, Hans-Eckart Radunz, Ernst Schulze, Bernhard Riefling
-
Patent number: 4622316Abstract: 13-thiaprostaglandins of Formula I ##STR1## wherein B is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,R.sup.1 is phenyl, CH.sub.3, or NH.sub.2,R.sup.2 is H or CH.sub.3, andR.sup.3 is pentyl, hexyl, 1-methylpentyl, or 1,1-dimethylpentylhave valuable pharmacological properties, e.g., as cytoprotective agents.Type: GrantFiled: November 8, 1984Date of Patent: November 11, 1986Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Bernd Simon, Hanns-Gerd Dammann, Peter Muller, Hans-Jurgen Legeler, Dieter Orth, Hans-Eckart Radunz
-
Patent number: 4309441Abstract: 13-Thiaprostanoic acid derivatives of the general formula I ##STR1## wherein A is --CO-- or --CHOH--; B is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--; Q is 1,4-phenylene or 1,4-naphthylene; R.sup.1 is H or OH; R.sup.2 is H or CH.sub.3 ; R.sup.3 is alkyl with 1-8 carbon atoms or alkyl with 1-8 carbon atoms substituted by (a) phenyl, (b) phenyl substituted by at least one of CH.sub.3, F, Cl, Br, OH, OCH.sub.3 or CF.sub.3 ; (c) phenoxy or (d) phenoxy substituted by at least one of CH.sub.3, F, Cl, Br, OH, OCH.sub.3 or CF.sub.3 ; and R.sup.4 is NH.sub.2, CH.sub.3, phenyl, p-acetylaminophenyl, p-benzoylaminophenyl or phenylamino. These compounds are useful for lowering blood pressure as well as for other pharmaceutical purposes. They also are useful intermediates for the preparation of other known pharmaceuticals such s the 13-thiaprostaglandins.Type: GrantFiled: November 21, 1979Date of Patent: January 5, 1982Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Hans-Eckart Radunz, Dieter Orth, Manfred Baumgarth, Hans-Jochen Schliep, Hans-Joachim Enenkel
-
Patent number: 4294839Abstract: Benzothiazole derivatives of the formula I ##STR1## wherein R.sup.1 is H or CH.sub.3 ; R.sup.2 is phenyl, tolyl, xylyl or pyridyl; R.sup.3 is OH, alkoxy of 1-4 C atoms or -NHCH.sub.2 CH.sub.2 OH; and R.sup.4 is H, Cl, Br, OH or alkoxy of 1-4 C atoms,and physiologically acceptable salts thereof, have valuable pharmacological properties.Type: GrantFiled: December 12, 1980Date of Patent: October 13, 1981Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Thomas Doll, Erich Schacht, Hans-Eckart Radunz, Ernst Schulze
-
Patent number: 4289768Abstract: Phenothiazine derivatives of the formula ##STR1## wherein R is H, F, Cl, Br, I, CH.sub.3, CF.sub.3, CN, CH.sub.3 O or CH.sub.3 CO; Y is S, SO, or SO.sub.2 ; Z is imidazol-1-yl, 2-methyl-imidazol-1-yl, pyrazol-1-yl or benzimidazol-1-yl; and n is 1, 2 or 3; or the physiologically acceptable acid addition salts thereof; are useful as antihypertensive agents, for example.Type: GrantFiled: May 2, 1980Date of Patent: September 15, 1981Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Joachim Gante, Hans-Eckart Radunz, Dieter Orth, Hans-Jochen Schliep, Ernst Schorscher
-
Patent number: 4258047Abstract: Pyrazole derivatives of the formula ##STR1## wherein R.sup.1 is H or Cl; R.sup.2 is 1-methyl-4-piperidyloxy-carbonyl, 2-(4-phenylpiperazino)-ethoxycarbonyl, benzoxazol-2-yl, benzthiazol-2-yl, tetrazol-5-yl or 3-R.sup.3 -4-R.sup.4 -thiazolidin-2-yl; R.sup.3 is H, alkanoyl of 1-7 carbon atoms or benzoyl; and R.sup.4 is H or COOH,or a physiologically acceptable salt thereof;possess valuable pharmacological activities.Type: GrantFiled: February 19, 1980Date of Patent: March 24, 1981Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Joachim Gante, Hans-Eckart Radunz, Dieter Orth, Klaus Minck, Albrecht Wild, Michael Klockow
-
Patent number: 4210651Abstract: 13-Thiaprostanoic acid derivatives of the formula ##STR1## wherein A is --CO-- or --CHOH--, B is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH-- R.sup.1 is H or alkyl of 1 to 4 carbon atoms, m is a whole number from 0 to 5, n is a whole number from 0 to 3 or, when B is --CH.dbd.CH--, additionally 4, 5, 6, 7, 8 or 9, R.sup.2 is alkoxy of 1 to 4 carbon atoms, phenoxy, pyridyl, thienyl, naphthyl, phenyl substituted by F, Cl, Br, OH, OCH.sub.3 or OF.sub.3 or phenoxy substituted by F, Cl, Br, OH, OCH.sub.3, CH.sub.3 or CF.sub.3 or, when B is --CH.dbd.CH--, additionally hydrogen, phenyl or tolyl, R.sup.3 is H, methyl or ethyl, possess pharmacological activity, including blood pressure lowering activity.Type: GrantFiled: January 18, 1978Date of Patent: July 1, 1980Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Hans-Eckart Radunz, Josef Kramer, Manfred Baumgarth, Dieter Orth
-
Patent number: 4209444Abstract: Compounds of formula ##STR1## their mirror images and racemic mixtures, and the physiologically acceptable salts thereof,wherein A and D each are ketalized carbonyl groups; B is --CH.sub.2 --, --CH(CH.sub.3)--, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.sub.2 --, --CH(CH.sub.3)CH.sub.2 ----C(CH.sub.3).sub.2 CH.sub.2 -- or --CH.sub.2 O--; R.sup.1 is H or alkyl of 1-4 C-atoms; and R.sup.2 is alkyl of 3 to 5 C-atoms, phenyl or phenyl substituted one to three times by F, Cl, CF.sub.3, OH, OCH.sub.3, OC.sub.2 H.sub.5 or alkyl of 1 to 3 C-atoms inhibit aggregation and/or adhesion of thrombocytes.Type: GrantFiled: November 29, 1977Date of Patent: June 24, 1980Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Manfred Baumgarth, Dieter Orth, Hans-Eckart Radunz, Reinhard Lissner, Jurgen Maisenbacher
-
Patent number: 4188403Abstract: Compounds of the Formula ##STR1## and the physiologically acceptable salts thereof, wherein R.sup.1 and R.sub.2 each is hydrogen or benzyl; R.sup.3 is alkyl of 5-10 C-atoms or 2-hydroxyalkyl of 5-10 C-atoms; R.sup.4 is hydrogen, methyl or ethyl; R.sup.5 is alkyl of 5-10 C-atoms or --C.sub.n H.sub.2n COOR.sup.6 ; R.sup.6 is hydrogen or alkyl of 1-4 C-atoms; and n is 0, 4, 5 or 6 are effective for inhibiting adhesion and/or agglomeration of thrombocytes.Type: GrantFiled: December 21, 1977Date of Patent: February 12, 1980Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Dieter Orth, Hans-Eckart Radunz, Manfred Baumgarth, Jurgen Maisenbacher, Reinhard Lissner
-
Patent number: 4125622Abstract: 1,4-Oxathianes of the formula ##STR1## and the physiologically-acceptable salts thereof wherein R.sup.1 is H or alkyl with 1-4 C-atoms; R.sup.2 is H or alkyl with 1-4 C-atoms; R.sup.3 is H, alkyl with 1-8 C-atoms, phenyl or phenyl substituted by F, Cl, Br, OH, OCH.sub.3, CF.sub.3 or NO.sub.2 ; R.sup.4 is H or CH.sub.3 ; B is a single bond, --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.sub.2 O--; and a wavy line ( ) indicates that these bonds can be in the .alpha.- or .beta.- positions possess thrombocyte inhibition properties.Type: GrantFiled: December 14, 1977Date of Patent: November 14, 1978Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Hans-Eckart Radunz, Dieter Orth, Manfred Baumgarth, Reinhard Lissner, Jurgen Maisenbacher
-
Patent number: 4113863Abstract: Prostenoic acid derivatives of the general formula ##STR1## wherein R.sup.1 is H or alkyl of 1-4 carbon atoms;R.sup.2 is alkyl of 5 - 9 carbon atoms, phenoxymethyl or phenoxymethyl substituted by up to 3 of F, Cl, Br, CH.sub.3, CF.sub.3, or OCH.sub.3 ;R.sup.3 is H or alkyl of 1 - 5 carbon atoms, and physiologically acceptable salts thereof, as well as intermediates therefore are blood-pressure lowering, vasodilatory, diuretic, and nasal mucosa decongesting agents and are produced from intermediates of the formula ##STR2## wherein R.sup.4 is H or acyl of up to 5 carbon atoms and A is CH.sub.2 D or CH.dbd.C(OR.sup.5); D is carbonyl or dialkoxypolymethylene of up to 7 carbon atoms.Type: GrantFiled: November 5, 1976Date of Patent: September 12, 1978Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Manfred Baumgarth, Hans-Eckart Radunz, Dieter Orth, Reinhard Lissner, Hans-Joachim Enenkel, Filippus Johannes Zeelen
-
Patent number: 4086362Abstract: Prostenoic acid derivatives of the general formula ##STR1## wherein R.sup.1 is H or alkyl or 1-4 carbon atoms;R.sup.2 is alkyl of 5 - 9 carbon atoms, phenoxymethyl or phenoxymethyl substituted by up to 3 of F, Cl, Br, CH.sub.3, CF.sub.3, or OCH.sub.3 ;R.sup.3 is H or alkyl or 1 - 5 carbon atoms, and physiologically acceptable salts thereof, as well as intermediates therefore are blood-pressure lowering, vasodilatory, diuretic and nasal mucosa decongesting agents.Type: GrantFiled: November 24, 1975Date of Patent: April 25, 1978Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Manfred Baumgarth, Hans-Eckart Radunz, Dieter Orth, Reinhard Lissner, Hans-Joachim Enenkel, Filippus Johannes Zeelen