Patents by Inventor Hans F. Schmitthenner
Hans F. Schmitthenner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10927132Abstract: A process for the preparation of a radionuclide imaging agent includes providing an imaging agent including a chelated place-holder metal; loading the imaging agent onto an acid stable stationary phase; replacing the chelated place-holder metal of the imaging agent loaded on the stationary phase with a replacement radioactive metal under mild reaction conditions; and eluting the imaging agent including the chelated replacement radioactive metal from the stationary phase to provide a radionuclide imaging agent suitable for positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The imaging agent can include a targeting agent that is directly conjugated to the imaging agent or by means of a linker. The process may also apply to other metals that are non-radioactive but used as diluent metals or other metals that are strongly bound to DOTA.Type: GrantFiled: February 26, 2016Date of Patent: February 23, 2021Assignee: Rochester Institute of TechnologyInventors: Hans F. Schmitthenner, Anne M. Sweeney-Jones, Scott Williams
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Patent number: 10610608Abstract: Targeted molecular imaging agents (TMIAs) are derived from coupling together pre-formed amino acids with imaging agents attached to their side chains. These peptide-based imaging agents may synthesized from a single or multiple preformed amino acids containing multi-modal, multi-chelated metal, multi-dye imaging agents, or combinations of these, on the side chains of resultant peptides. These imaging amino acids or peptides may be conjugated directly, or activated, or attached to linkers to which targeting groups, such as peptides, proteins, antibodies, aptamers, or small molecule inhibitors, may be conjugated in the final steps of the synthesis to form a wide variety of TMIAs.Type: GrantFiled: August 1, 2014Date of Patent: April 7, 2020Assignee: Rochester Institute of TechnologyInventors: Hans F. Schmitthenner, Stephanie Beach, Taylor Barrett, Chelsea Weidman
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Publication number: 20170246326Abstract: Targeted molecular imaging agents (TMIAs) are derived from coupling together pre-formed amino acids with imaging agents attached to their side chains. These peptide-based imaging agents may be synthesized from a single or multiple preformed amino acids containing multi-modal, multi-chelated metal, multi-dye imaging agents, or combinations of these, on the side chains of resultant peptides. These imaging amino acids or peptides may be conjugated directly, or activated, or attached to linkers to which targeting groups, such as peptides, proteins, antibodies, aptamers, or small molecule inhibitors, may be conjugated in the final steps of the synthesis to form a wide variety of TMIAs.Type: ApplicationFiled: May 11, 2017Publication date: August 31, 2017Applicant: Rochester Institute of TechnologyInventors: Hans F. Schmitthenner, Stephanie Beach, Taylor Barrett, Chelsea Weidman
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Publication number: 20160251378Abstract: A process for the preparation of a radionuclide imaging agent includes providing an imaging agent including a chelated place-holder metal; loading the imaging agent onto an acid stable stationary phase; replacing the chelated place-holder metal of the imaging agent loaded on the stationary phase with a replacement radioactive metal under mild reaction conditions; and eluting the imaging agent including the chelated replacement radioactive metal from the stationary phase to provide a radionuclide imaging agent suitable for positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The imaging agent can include a targeting agent that is directly conjugated to the imaging agent or by means of a linker. The process may also apply to other metals that are non-radioactive but used as diluent metals or other metals that are strongly bound to DOTA.Type: ApplicationFiled: February 26, 2016Publication date: September 1, 2016Applicant: Rochester Institute of TechnologyInventors: Hans F. Schmitthenner, Anne M. Sweeney-Jones, Scott Williams
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Publication number: 20150038672Abstract: Targeting agents are derived from coupling together formed imaging amino acids or formed multi-modal, multi-chelating metal, multi-dye imaging agents, or combinations of these, that may be conjugated directly, or activated, or attached to linkers to which targeting groups, such as peptides, proteins, antibodies, aptamers, or small molecule inhibitors, may be conjugated in the final steps of the synthesis to form a wide variety of TMIAs.Type: ApplicationFiled: August 1, 2014Publication date: February 5, 2015Applicant: Rochester Institute of TechnologyInventors: Hans F. Schmitthenner, Stephanie Beach, Chelsea Weidman, Taylor Barrett
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Patent number: 8906354Abstract: The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.Type: GrantFiled: March 8, 2011Date of Patent: December 9, 2014Assignee: Bruker Biospin CorporationInventors: Tao Ji, Hans F. Schmitthenner, Yonghong Yang, John W. Harder, Jeffrey W. Leon, William J. Harrison, Brian J. Kelley, James R. Bennett, David A. Stegman, Ruizheng Wang
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Publication number: 20120058050Abstract: The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.Type: ApplicationFiled: March 8, 2011Publication date: March 8, 2012Inventors: Tao Ji, Hans F. Schmitthenner, Yonghong Yang, John W. Harder, Jeffrey W. Leon, William J. Harrison, Brian J. Kelley, James R. Bennett, David A. Stegman, Ruizheng Wang
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Patent number: 8017104Abstract: The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.Type: GrantFiled: February 28, 2007Date of Patent: September 13, 2011Assignee: Carestream Health, Inc.Inventors: Ruizheng Wang, John W. Harder, David A. Stegman, William J. Harrison, Hans F. Schmitthenner
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Publication number: 20080206886Abstract: The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.Type: ApplicationFiled: February 28, 2007Publication date: August 28, 2008Inventors: Ruizheng Wang, John W. Harder, David A. Stegman, William J. Harrison, Hans F. Schmitthenner
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Patent number: 7208233Abstract: An electroluminescent device comprising a host material and a rubrene derivative having a naphthacene nucleus comprising four fused phenyl rings a, b, c, and d, in order, containing two secondary phenyl ring groups linked to the ācā ring, each bearing directly or indirectly a fluoro or perfluoroalkyl group, wherein each fluoro or perfluoroalkyl group is either: a) linked directly to one of said secondary phenyl rings and is located on a meta or ortho position, or b) located in any position of another aryl group linked directly or indirectly to one of the secondary phenyl rings.Type: GrantFiled: March 16, 2004Date of Patent: April 24, 2007Assignee: Eastman Kodak CompanyInventors: Margaret J. Helber, Tukaram K. Hatwar, Hans F. Schmitthenner, Peter G. Bessey, Manju Rajeswaran
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Patent number: 7066992Abstract: The invention relates to an ink composition comprising solubilized yellow dyes for inks with improved ozone and light stability.Type: GrantFiled: December 10, 2003Date of Patent: June 27, 2006Assignee: Eastman Kodak CompanyInventors: Joan C. Potenza, Marcel B. Madaras, Hans F. Schmitthenner, David T. Southby, Mihaela L. Madaras
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Patent number: 7056375Abstract: This invention relates to an ink composition comprising a dye represented by Formula I: wherein R1 is independently a non-metallic substituent; s is 0, 1, 2, 3, or 4; R2 is hydrogen or a non-metallic substituent; R3 is a substituted or unsubstituted aromatic or heterocyclic group with the proviso that if R3 is a quinoline moiety, the azo group is not bonded to the 5, 6, 7 or 8 position of the quinoline ring; wherein the dye must bear at least one ionizable group that is capable of imparting water solubility to the dye. It also relates to dyes which comprise a specific subset of the above dyes.Type: GrantFiled: September 7, 2004Date of Patent: June 6, 2006Assignee: Eastman Kodak CompanyInventors: Joan C. Potenza, Marcel B. Madaras, Hans F. Schmitthenner, David T. Southby
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Patent number: 6946562Abstract: Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product from the resin surface using a fluorinated organic acid in an inert solvent.Type: GrantFiled: December 12, 2001Date of Patent: September 20, 2005Assignee: Eastman Kodak CompanyInventors: Donald R. Diehl, Robert J. Niger, Hans F. Schmitthenner, William J. Sonnefeld, Richard P. Dunlap
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Publication number: 20030187188Abstract: Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product from the resin surface using a fluorinated organic acid in an inert solvent.Type: ApplicationFiled: December 12, 2001Publication date: October 2, 2003Inventors: Donald R. Diehl, Robert J. Niger, Hans F. Schmitthenner, William J. Sonnefeld, Richard P. Dunlap
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Patent number: 6514679Abstract: Disclosed is a photographic element comprising a silver halide emulsion and a peptoid-containing azole dye-forming coupler.Type: GrantFiled: December 12, 2001Date of Patent: February 4, 2003Assignee: Eastman Kodak CompanyInventors: Donald R. Diehl, Robert J. Niger, Richard P. Dunlap, William J. Sonnefeld, Hans F. Schmitthenner
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Patent number: 4758679Abstract: In a process for preparing 7-[3-(propylamino)-2-hydroxypropoxy]flavone by the reaction of 7-(2,3-epoxypropoxy)flavone and n-propylamine, the improvement which resides in treating the beta-aminochalcone by-product with a weak organic acid to convert the chalcone to the desired aminated flavone.Type: GrantFiled: July 18, 1986Date of Patent: July 19, 1988Assignee: Pennwalt CorporationInventors: Hans F. Schmitthenner, Edwin S. C. Wu
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Patent number: 4758678Abstract: 7-(2,3-Epoxypropoxy)flavone is prepared by the reaction of 7-hydroxyflavone with an epihalohydrin in the presence of a weak base and acetonitrile.Type: GrantFiled: July 18, 1986Date of Patent: July 19, 1988Assignee: Pennwalt CorporationInventor: Hans F. Schmitthenner