Abstract: A method for operating a multi-beam particle microscope which operates using a plurality of individual charged particle beams, wherein the method includes the following steps: measuring the beam current; determining a deviation of the measured beam current from a nominal beam current; decomposing the determined deviation into a drift component and into a high-frequency component; and controlling the high-frequency component of the beam current via a first closed-loop beam current control mechanism and/or compensating an effect of the high-frequency component on a recording quality of the multi-beam particle microscope using different mechanism than a closed-loop beam current control mechanism. An electrostatic control lens arranged in the beam generating system between extractor and anode can be used as first closed-loop beam current control mechanism. Adapting an extractor voltage of the beam generating system can be avoided.

Abstract: A particle beam system includes a multi-source system. The multi-source system comprises an electron emitter array as a particle multi-source. The inhomogeneous emission characteristics of the various emitters in this multi-source system are correctable, or pre-correctable for subsequent particle-optical imaging, via particle-optical components that are producible via MEMS technology. A beam current of the individual particle beams is adjustable in the multi-source system.

Abstract: A particle beam system includes: a particle source to generate a beam of charged particles; a first multi-lens array including a first multiplicity of individually adjustable and focusing particle lenses so that at least some of the particles pass through openings in the multi-lens array in the form of a plurality of individual particle beams; a second multi-aperture plate including a multiplicity of second openings downstream of the first multi-lens array so that some of the particles which pass the first multi-lens array impinge on the second multi-aperture plate and some of the particles which pass the first multi-lens array pass through the openings in the second multi-aperture plate; and a controller configured to supply an individually adjustable voltage to the particle lenses of the first multi-lens array and thus individually adjust the focusing of the associated particle lens for each individual particle beam.

Abstract: A particle beam system includes a multiple beam particle source to generate a multiplicity of charged individual particle beams, and a multi-pole lens sequence with first and second multi-pole lens arrays. The particle beam system also includes a controller to control the multi-pole lenses of the multi-pole lens sequence so related groups of multi-pole lenses of the multi-pole lens sequence through which the same individual particle beam passes in each case altogether exert an individually adjustable and focussing effect on the respective individual particle beam passing therethrough.

Abstract: Certain improvements of multi-beam raster units such as multi-beam generating units and multi-beam deflector units of a multi-beam charged particle microscopes are provided. The improvements include design, fabrication and adjustment of multi-beam raster units including apertures of specific shape and dimensions. The improvements can enable multi-beam generation and multi-beam deflection or stigmation with higher precision. The improvements can be relevant for routine applications of multi-beam charged particle microscopes, for example in semiconductor inspection and review, where high reliability and high reproducibility and low machine-to-machine deviations are desirable.

Abstract: A particle beam system and, such as a multi-beam particle microscope, can have a current intensity of individual particle beams that is flexibly set over large value ranges without structural modifications. The particle beam system can include a condenser lens system, a pre-multi-lens array with a specific pre-counter electrode and a pre-multi-aperture plate, and a multi-lens array. The system can includes a controller to supply adjustable excitations to the condenser lens system and the pre-counter electrode so that the charged particles are incident on the pre-multi-aperture plate in telecentric manner.

Abstract: A method includes operating a multiple particle beam system at different working points. The numerical aperture can be set for each of the working points in such a way that the resolution of the multiple particle beam system is optimal. In the process, the beam pitch between adjacent individual particle beams on the sample to be scanned is kept constant as a boundary condition. There are no mechanical reconfigurations of the system whatsoever for the purposes of varying the numerical aperture.

Abstract: A particle beam system includes a multi-beam particle source for generating a multiplicity of charged individual particle beams, and a magnetic multi-deflector array for deflecting the individual particle beams in the azimuthal direction. The magnetic multi-deflector array includes a magnetically conductive multi-aperture plate having a multiplicity of openings, which is arranged in the beam path of the particle beams such that the individual particle beams substantially pass through the openings of the multi-aperture plate. The magnetic multi-deflector array also includes a magnetically conductive aperture plate having an individual opening. The aperture plate is arranged in the beam path of the particle beams such that the individual particle beams substantially pass through the first aperture plate. The multi-aperture plate and the first aperture plate are connected to each other such that a cavity is formed between the two plates.

Abstract: Provided is a controller for an electrical drive unit—which drives a treatment needle—of an ophthalmosurgical handpiece, comprising a generator unit, which provides a control variable with control oscillation, wherein the control oscillation has a first oscillation component at a first control frequency, wherein the first oscillation component is settable depending on a first ratio of a mechanical deflection amplitude of the treatment needle to the electrical control variable at the first control frequency. It is proposed that the generator unit is configured to provide the control oscillation of the control variable with at least one further oscillation component at a further control frequency, different than any other control frequency, in such a way that the further oscillation component is settable depending on a further ratio of the mechanical deflection amplitude of the treatment needle to the electrical control variable at the respective further control frequency.

Abstract: A particle beam system includes: a particle source to generate a beam of charged particles; a first multi-lens array including a first multiplicity of individually adjustable and focusing particle lenses so that at least some of the particles pass through openings in the multi-lens array in the form of a plurality of individual particle beams; a second multi-aperture plate including a multiplicity of second openings downstream of the first multi-lens array so that some of the particles which pass the first multi-lens array impinge on the second multi-aperture plate and some of the particles which pass the first multi-lens array pass through the openings in the second multi-aperture plate; and a controller configured to supply an individually adjustable voltage to the particle lenses of the first multi-lens array and thus individually adjust the focusing of the associated particle lens for each individual particle beam.

Abstract: A particle beam system includes: a multi-beam particle source configured to generate a multiplicity of particle beams; an imaging optical unit configured to image an object plane in particle-optical fashion into an image plane and direct the multiplicity of particle beams on the image plane; and a field generating arrangement configured to generate electric and/or magnetic deflection fields of adjustable strength in regions close to the object plane. The particle beams are deflected in operation by the deflection fields through deflection angles that depend on the strength of the deflection fields.

Abstract: In a method and apparatus for the longitudinal and lateral guidance assistance to the driver of a vehicle, longitudinal guidance assistance is performed as distance regulation for regulating the distance between the vehicle and a preceding guide vehicle. Lateral guidance assistance is optionally carried out as an object tracking regulation for guiding the vehicle according to a displacement lane of a preceding guide vehicle, as a lane tracking regulation for guiding the vehicle along a marked driving lane, or as combined lane object tracking regulation. The lateral guidance assistance is then available only when the distance regulation is active and when the distance between the vehicle and the guide vehicle is smaller than a predefined distance limit and/or when a shaft angle as a viewing angle from the vehicle to the guide vehicle is smaller than a predefined angle limit.

Abstract: The present invention relates to an adsorbing material which comprises at least one porous functional solid, e.g. a zeolite, incorporated in a polymer matrix. The adsorbing material contains the porous functional solid in an amount of 45 to 80 wt. %. The polymer matrix comprises at least one organic polymer, particularly selected from thermoplastics, and has a secondary pore volume in addition to the primary pore volume of the porous functional solid. Further, the present invention is directed to a shaped article, which comprises or consists of the afore-mentioned adsorbing material, to a method for its preparation and to its use. The present invention is finally conerned with the use of specific rheological additives, in particular waxy components, which function as pore-forming agents in the preparation of shaped articles.

Abstract: The invention relates to DNA sequences which code an eglin, expression plasmids containing such DNA sequences, hosts transformed with such expression plasmids, novel eglin compounds produced from such transformed hosts, monoclonal antibodies against eglins, hybridoma cells which produce such antibodies, and test kits for immunoassays containing such antibodies, and furthermore the processes for their preparation and a process for the preparation of eglins with the aid of the transformed hosts. The eglins which can be prepared according to the invention have useful pharmacological properties.

Abstract: The invention relates to a method for isolating anionic organic substances from aqueous systems using polymer nanoparticles with cationic pH-sensitive surface groups. Extraction can be carried out directly from diluted solutions, biological media (blood plasma, serum, urine, etc.) and complex buffer systems (e.g. PCR preparations contain detergents) without prior derivatization of the samples or addition of binding buffers. After separation from the surrounding medium the conjugates of the corresponding substances and polymer nanoparticles obtained in this manner can be purified through additional washing steps and effectively desalinated. Owing to the pH-sensitivity of the basic surface groups, the bound substances can be released in a targeted manner after separation by modification of the pH of the medium. By using volatile bases contamination of the released samples with ionic residues can be avoided.

Abstract: The invention relates to DNA sequences which code an eglin, expression plasmids containing such DNA sequences, hosts transformed with such expression plasmids, novel eglin compounds produced from such transformed hosts, monoclonal antibodies against eglins, hybridoma cells which produce such antibodies, and test kits for immunoassays containing such antibodies, and furthermore the processes for their preparation and a process for the preparation of eglins with the aid of the transformed hosts. The eglins which can be prepared according to the invention have useful pharmacological properties.

Abstract: A measuring and control system for a vehicle, having a measuring device for measuring the spacing between a following vehicle and a leading vehicle travelling ahead. The system involves a regulating and control unit for producing actuating signals as a function of measurement signals of the measuring device. In order to implement transverse guidance of a vehicle, the drawbar angle formed during cornering between the following vehicle and the leading vehicle is determined. The drawbar angle is formed between the longitudinal axis of the following vehicle and a connecting line between the following vehicle and the leading vehicle and is determined in the measuring device as an additional measurement signal. A steering signal is produced in the regulating and control unit as an actuating signal for the transverse guidance of the following vehicle as a function of the drawbar angle.

Abstract: In a process and a system for controlling the longitudinal dynamics of a motor vehicle, a drive train actuating signal is determined from actual vehicle condition data, controller-internal desired longitudinal velocity values, and desired longitudinal acceleration values determined by means of fed input data concerning the desired longitudinal acceleration and the actual driving condition. According to the invention, as a function of the controller-internal desired longitudinal velocity values and desired longitudinal acceleration values as well as of actual driving condition data, by means of an inverse characteristic vehicle longitudinal dynamics diagram, a desired drive train actuating signal is determined and the drive train actuating signal is determined therefrom.

Abstract: The invention provides a method and apparatus for controlling the longitudinal dynamics of a motor vehicle, in which, as control output signal, at least one drive train actuating signal is generated as a function of input data comprising the current driving state of the vehicle, and the desired longitudinal speed or the desired longitudinal acceleration.Using these input data, controller-internal values for the desired longitudinal speed and the desired longitudinal acceleration are determined, and the drive train actuating signal is ascertained therefrom using an inverse vehicle longitudinal dynamics model to take into account the non-linear dynamics of vehicle behaviour, which is particularly relevant in the low driving speed range.

Abstract: The present invention relates to novel inhibitors of human tryptase, to their isolation from leeches, to nucleotide sequences encoding the novel inhibtor molecules or fragments thereof, to vectors containing the coding sequence thereof, to host cells transformed with such vectors, to the recombinant production of the inibitors, to pharmaceutical compositions containing the novel inhibitor molecules, and to their use in diagnosis and therapy.