Patent number: 6294668
Abstract: The present invention relates to cephalosporin derivatives of the general formula
where
R1 is halogen, lower alkyl, phenyl, benzyl, styryl, naphthyl or heterocyclyl; the lower alkyl, phenyl, benzyl, styryl, naphthyl and heterocyclyl being optionally substituted by at least one of halogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted phenyl, amino, lower alkylamino, di-lower alkylamino, carboxy, lower alkylcarboxy, carbamoyl or lower alkylcarbamoyl;
R4, R5 independently are hydrogen, lower alkyl or phenyl;
X is S, O, NH or CH2;
n is 0,1 or 2;
m is 0 or 1;
s is 0 or 1;
R2 is hydrogen, hydroxy, —CH2—CONHR6, lower alkyl-Qr, cycloalkyl-Qr, lower alkoxy, lower alkenyl, cycloalkenyl-Qr, lower alkynyl, aralkyl-Qr, aryl-Qr, aryloxy, aralkoxy, a heterocyclic ring or a heterocyclyl-Qr, the lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aralkyl, aryl, aryloxy, aralkoxy and the heterocyclic
Type:
Grant
Filed:
November 5, 1997
Date of Patent:
September 25, 2001
Assignee:
Hoffman-La Roche Inc.
Inventors:
Peter Angehrn, Ingrid Heinze-Krauss, Hans G. F. Richter