Patents by Inventor Hans-Georg Batz
Hans-Georg Batz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030165540Abstract: The invention relates to a new virus, designated H101.c33 or Sentinel Virus II (SVII). Isolated SVII viruses, polynucleotides and proteins from SVII viruses, and antibodies which bind SVII virus and SVII viral proteins are provided. The polynucleotides, proteins, and antibodies of the invention may be used to detect SVII virus or infection by SVII virus in a susceptible individual. Additionally, polynucleotides of the invention may be inserted into recombinant expression vectors for recombinant production of viral proteins.Type: ApplicationFiled: May 4, 2001Publication date: September 4, 2003Inventors: Jen-Kuei Liu, Samantha Lewis, Hans-Georg Batz, Latha Ramaswamy, Roy Bohenzky, Yu-Huei Lin, Janine Montiel, Benjamin P. Chen
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Patent number: 6521744Abstract: Nucleic acid analogs provide a particularly useful tool for the preparation of complex polymeric structures of defined geometry because they are relatively stable to reaction conditions for the preparation of such structures and provide the opportunity to induce reactive groups which would not be possible with usual nucleic acids.Type: GrantFiled: September 7, 2000Date of Patent: February 18, 2003Assignee: PNA Diagnostics A/SInventors: Hans-Georg Batz, Troels Koch, Henrik Frydenlund Hansen
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Patent number: 6310179Abstract: Nucleic acid analogues provide a particularly useful tool for the preparation of complex polymeric structures of defined geometry because they are relatively stable to reaction conditions for the preparation of such structures and provide the opportunity to introduce reactive groups which would not be possible with usual nucleic acids. These supramolecular structures can be used to form fine networks in nanometer size, for the preparation of e.g., computer chips, new materials/polymers with conductivity and/or insulator properties, and robot arms in nanometer scale.Type: GrantFiled: May 28, 1998Date of Patent: October 30, 2001Assignee: Dako A/SInventors: Hans-Georg Batz, Troels Koch, Henrik Frydenlund Hansen
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Patent number: 6225052Abstract: New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.Type: GrantFiled: November 21, 1997Date of Patent: May 1, 2001Assignees: Roche Diagnostics GmbH, Georgia Tech Research CorporationInventors: Hans-Georg Batz, Henrik Frydenlund Hansen, Henrik Orum, Troels Koch, Gary B. Schuster, Bruce A. Armitage, Danith Ly
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Patent number: 6210901Abstract: The invention relates to derivatives of hepatitis C virus amino acid sequences. These derivatives can be used to screen samples, such as blood, to determine if antibodies to hepatitis C virus are present.Type: GrantFiled: July 31, 1996Date of Patent: April 3, 2001Assignee: Roche Diagnostics GmbHInventors: Christoph Seidel, Rupert Herrmann, Eva Hoess, Hans-Georg Batz
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Patent number: 6211158Abstract: The present invention provides desazapurine-nucleoside derivatives of the general formula: wherein X is a nitrogen atom or a methine radical, W is a nitrogen atom or a C—R4 radical, R1, R2, R3 and R4, which can be the same or different, are hydrogen or halogen atoms, hydroxyl or mercapto groups, lower alkyl, lower alkylthio, lower alkoxy, aralkyl, aralkoxy or aryloxy radicals or amino groups optionally substituted once or twice, R5 is a hydrogen atom or a hydroxyl group, R6 and R7 are each hydrogen atoms or one of them is a halogen atom or a cyano or azido group or an amino group optionally substituted once or twice, whereby one of R6 and R7 can also be a hydroxyl group when X is a methine radical and, in addition, R5 and R7 can together also represent a further valency bond between C-2′ and C-3′ and Y is a hydrogen atom or a mono-, di- or tri-phosphate group.Type: GrantFiled: June 26, 1992Date of Patent: April 3, 2001Assignee: Roche Diagnostics GmbHInventors: Frank Seela, Heinz-Peter Muth, Klaus Kaiser, Werner Bourgeois, Klaus Mühlegger, Herbert Von der Eltz, Hans-Georg Batz
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Patent number: 6117973Abstract: New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.Type: GrantFiled: February 24, 1997Date of Patent: September 12, 2000Assignees: Georgia Tech Research Corp., Roche Diagnostics GmbHInventors: Hans-Georg Batz, Henrik Frydenlund Hansen, Henrik Orum, Troels Koch, Gary B. Shuster, Bruce A. Armitage
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Patent number: 6081734Abstract: A control system for monitoring the regular intake of a medicament by a patient. The system comprises system components mutually tuned to each other and comprising a medicine dosage form (1) for the medication and a detection apparatus (2) for non-invasive detection, within the body of the patient, of a detection substance contained in the medicine dosage form (3). The detection apparatus (2) is adapted for reagent-free direct measurement of a physically measurable parameter correlated with the presence of the detection substance in the body of the patient.Type: GrantFiled: January 29, 1999Date of Patent: June 27, 2000Assignee: Roche Diagnostics GmbHInventor: Hans-Georg Batz
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Patent number: 5902878Abstract: The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.Type: GrantFiled: September 19, 1997Date of Patent: May 11, 1999Assignee: Boehringer Mannheim GmbHInventors: Heinz-Hartmut Seliger, Sibylle Berner, Klaus Muhlegger, Herbert Von Der Eltz, Hans-Georg Batz
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Patent number: 5851840Abstract: The invention concerns a binding matrix containing a carrier material with an oxidic surface and a solid phase reactant covalently bound thereto via anchor groups which is capable of binding to at least one free reaction partner, which is characterized in that the solid phase reactant forms a diluted and essentially laterally homogeneous binding layer on the surface of the carrier material and that the anchor groups are silane groups and are linked to the solid phase reactant via a spacer molecule.Type: GrantFiled: December 31, 1996Date of Patent: December 22, 1998Assignee: Boehringer Mannheim GmbHInventors: Peter Sluka, Hans-Georg Batz
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Patent number: 5700919Abstract: The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.Type: GrantFiled: January 10, 1995Date of Patent: December 23, 1997Assignee: Boehringer Mannhiem GmbHInventors: Heinz-Hartmut Seliger, Sibylle Berner, Klaus Muhlegger, Herbert Von der Eltz, Hans-Georg Batz
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Patent number: 5646255Abstract: Immunogens of formula I are provided for obtaining HbA.sub.1c -specific antibodies ##STR1## M is 1 to 40, T is a carrier protein and A is a 10-20 atoms spacer and is ##STR2## where X is S or --NH--, n is 1 to 4 and B is a succinimide containing organic radical. The antibodies obtained bind glycosylated hemoglobin to determine HbA.sub.1c in body fluids.Type: GrantFiled: August 15, 1994Date of Patent: July 8, 1997Assignee: Boehringer Mannheim GmbHInventors: Christian Klein, Christa Hubner-Parajsz, Hans-Georg Batz, Wolfgang Rollinger, Ulrich Essig, Lorenz Kerscher
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Patent number: 5632993Abstract: The present invention provides immunogens for obtaining HbA.sub.1c -specific antibodies, which immunogens have the general formula: ##STR1## wherein M is 1 to 40, T is a carrier protein and A is a spacer which has a chain length of 10 to 20 atoms and has the general formula: ##STR2## wherein X is a sulphur atom or au --NH-- group, n is 1 to 4 and B is an organic radical which contains a succinimide group. The present invention also provides a process for obtaining antibodies which specifically bind glycosylated haemoglobin, wherein an immunogen of general formula (I) is injected into an organism capable of antibody formation and the antibodies are then obtained in known manner. These antibodies can be used for determining HbA.sub.1c in body fluids.Type: GrantFiled: May 16, 1995Date of Patent: May 27, 1997Assignee: Boehringer Mannheim GmbHInventors: Christian Klein, Christa Hubner-Parajsz, Hans-Georg Batz, Wolfgang Rollinger, Ulrich Essig, Lorenz Kerscher
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Patent number: 5595741Abstract: The invention concerns new aminoalkylmaleimides of the general formula I ##STR1## in which R.sub.1 and R.sub.2 are the same or different and represent hydrogen or a C.sub.1 -C.sub.4 alkyl group and A represents a straight-chain or branched, saturated or unsaturated alkylene group with 2 to 6 carbon atoms which is interrupted, if desired, by an oxygen or sulphur atom or a carbonyl group, as well as their corresponding acid addition salts.The present invention also concerns amidoalkylmaleimide derivatives formed from compounds of the general formula I and immunological binding partners. In addition, the invention concerns immunological conjugates which can be produced by reaction of the amidoalkylmaleimide derivatives with peptides or proteins.The subject matter of the present invention are also the corresponding processes of production of the compounds according to the present invention as well as the use of these conjugates in diagnostic methods of determination, in particular in immunoassays.Type: GrantFiled: July 21, 1994Date of Patent: January 21, 1997Assignee: Boehringer Mannheim GmbHInventors: Emasmus Huber, Christian Klein, Hans-Georg Batz, Bruno Zink
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Patent number: 5321129Abstract: Novel compounds having the general formulaS--Ar--Xin whichS denotes a saccharide residueAr denotes an aryl residue andX denotes a straight-chained or branched alkyl residue with 2 to 20 carbon atoms,provided that the aryl residue may not be a 4-ethylphenyl, 4-isopropylphenyl, 4-sec.-butyl or 4-dodecylphenyl residue if the saccharide is a galactopyranoside residue, are interesting surface-active agents and are particularly suitable in diagnostic tests in order to clear serum.Type: GrantFiled: May 14, 1992Date of Patent: June 14, 1994Assignee: Boehringer Mannheim GmbHInventors: Peter Sluka, Hans-Georg Batz, Bernd Vogt
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Patent number: 5304645Abstract: The present invention provides resorufin derivatives of the general formulae: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5, which can be the same or different, are hydrogen, halogen, carboxyl, carboxamido, lower alkoxycarbonyl, cyano or nitro groups or lower alkyl or lower alkoxy radicals, which can be substituted by carboxyl, carboxamido, lower alkoxycarbonyl, cyano or nitro groups, and wherein R.sup.4 and R.sup.5 can together also represent an anellated aromatic residue, Z is a bridge member, A is the residue of a ligand and n is a whole number of from 1 to 200.The present invention also provides processes for the preparation of these resorufin derivatives, as well as intermediates for the preparation thereof.Type: GrantFiled: March 28, 1991Date of Patent: April 19, 1994Assignee: Boehringer Mannheim GmbHInventors: Christian Klein, Hans-Georg Batz, Rupert Herrmann
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Patent number: 5070025Abstract: The present invention provides a process for the determination of a protein according to the fluorescence polarization immunoassay principle in a homogeneous system by simultaneous incubation of the sample solution witha) a peptide sequence, labelled with a fluorescing compound, of 6 to 14 amino acids, two of which are cysteine which form a disulphide bridge with one another, the sequence thereby corresponding to an epitope sequence of the protein to be determined, andb) an antibody which is specifically bindable not only with the protein but also with the peptide sequence and displays for the fluorescing peptide sequence of the protein and the native protein molar relative affinities which differ by a factor of at most 6, and measurement of the depolarization of polarized light passed through the incubated solution.Type: GrantFiled: February 15, 1989Date of Patent: December 3, 1991Assignee: Boehringer Mannheim GmbHInventors: Christian Klein, Hans-Georg Batz, Ulrich Essig, Kurt W. Naujoks
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Patent number: 5032518Abstract: The present invention provides a hapten-protein conjugate, wherein a hapten is bound to the reducing end of a sugar which consists of up to 10 monosaccharide units and on a free CH.sub.2 OH group on the other end of the sugar, which is in the .alpha.-position to a hydroxyl group, is bound a protein.Type: GrantFiled: January 25, 1989Date of Patent: July 16, 1991Assignee: Boehringer Mannheim GmbHInventors: Erasmus Huber, Hans-Georg Batz, Herbert von der Eltz, Christian Klein
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Patent number: 4988497Abstract: The present invention provides a lipase substrate of the general formula: ##STR1## wherein A is an alkalene or alkenylene radical containing up to 16 carbon atoms, R and R.sub.1, which can be the same or different, each signify an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety and wherein one of R and R.sub.1 can also be a hydrogen atom, X is the residue of an aromatic hydroxy or thiol compound, and each Y and Z, independently from each other, is --S-- or --O--, Z also --CH.sub.2 --.The present invention also provides a process and a reagent for the optical determination of lipase.Type: GrantFiled: May 17, 1989Date of Patent: January 29, 1991Assignee: Boehringer Mannheim GmbHInventors: Ulrich Neumann, Martina Junius, Hans-Georg Batz
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Patent number: RE34864Abstract: The present invention provides a carrier for coating with immunologically-active material, wherein it consists of an injection molded synthetic resin with a content of adjuvant and additional materials of less than 1% by weight. The present invention also provides a carrier coated with immunologically-active material, wherein the carrier consists of synthetic resin with a content of adjuvant and additional materials of less than 1% by weight.Type: GrantFiled: December 1, 1992Date of Patent: February 21, 1995Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Herbert Hopp, Klaus Stellner