Abstract: A fluidic apparatus for a sample separation system includes a fluid inlet path for supplying a fluid, an inlet sensor adapted for measuring a flow rate of the fluid in the fluid inlet path, a splitting point arranged downstream of the fluid inlet path and adapted for splitting the fluid into a first path and into a second path, and a second path sensor adapted for measuring a flow rate of a part of the fluid conducted into the second path.

Abstract: Disclosed is a pumping apparatus (200) configured for delivering a fluid. The pumping apparatus (200) comprises a pumping chamber (220) configured for receiving one or more fluids (310, 320) in defined proportions and for further delivering the received fluids, an outlet (240), fluidically coupling to a first position (350) in the pumping chamber (220), for outleting the fluid to be delivered, and a channel (410). The channel (410) fluidically couples on one side to a second position (340) in the pumping chamber (220) and on the other side to the outlet (240), so that—in operation—a first portion of the delivered fluid as outlet at the outlet (240) is received from the first position (350) in the pumping chamber (220), and a second portion of the delivered fluid as outlet at the outlet (240) is received from the second position (340) in the pumping chamber (220).

Abstract: A method of determining a leak in a pumping system includes determining a metered flow rate of a fluid through a first channel, determining a measured flow rate within the channel, and identifying an amount of a leak in the pumping system as the difference between the metered flow rate and the measured flow rate.

Abstract: A fluidic apparatus for a sample separation system includes a fluid inlet path for supplying a fluid, an inlet sensor adapted for measuring a flow rate of the fluid in the fluid inlet path, a splitting point arranged downstream of the fluid inlet path and adapted for splitting the fluid into a first path and into a second path, and a second path sensor adapted for measuring a flow rate of a part of the fluid conducted into the second path.

Abstract: A method of determining a leak in a pumping system includes determining a metered flow rate of a fluid through a first channel, determining a measured flow rate within the channel, and identifying an amount of a leak in the pumping system as the difference between the metered flow rate and the measured flow rate.

Abstract: A liquid chromatograph includes a mobile phase supplying apparatus including liquid-feeding pumps to feed mobile phases, liquid-feeding flow paths, a mixer to mix the mobile phases, at least one control device to control each liquid-feeding pump, flow rate measuring sections provided downstream in each liquid-feeding flow path configured to measure an actual flow rate and to detect a back-flow, and actual flow rate computing sections configured to compute an actual flow rate in the corresponding liquid feeding flow path. Also included are a sample injecting section downstream of the mobile phase supplying apparatus, a separating column for separating an injected sample into its constituents, and a detector for detecting each of the separated constituents. When one of the actual flow rate measuring sections detects a back-flow, the corresponding actual flow-rate computing section computes an actual back-flow rate and outputs a signal to the corresponding control device to cancel the back-flow.

Abstract: A handling unit that comprises a first clamping element and a second clamping element, and an actuation mechanism adapted for driving at least one of the clamping elements. When the at least one of the clamping elements is driven to a first position, a microfluidic device may be placed between the clamping elements or taken out of the clamping elements, and when the at least one of the clamping elements is driven to a second position, the microfluidic device is gripped and fastened by the clamping elements.

Abstract: A liquid chromatograph includes a mobile phase supplying apparatus including a plurality of liquid-feeding pumps to feed mobile phases, a plurality of liquid-feeding flow paths, a mixer to mix the mobile phases by merging the liquid-feeding flow paths, at least one control device to control driving of each of the liquid-feeding pumps based on flow rates for the respective liquid-feeding flow paths, a plurality of flow rate measuring sections provided downstream of the liquid feeding pump in each liquid-feeding flow path, the plurality of actual flow rate measuring sections configured to measure an actual flow rate and to detect a back-flow in the corresponding liquid-feeding flow path, and a plurality of actual flow rate computing sections configured to compute an actual flow rate in the corresponding liquid feeding flow path.

Abstract: A liquid delivery system having at least one channel, at least one valve within that channel, at least one flow sensing device within that channel, and a pressure source downstream of the valve capable for generating variable pressures.

Abstract: A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid are pumped through the system. A number of techniques for detecting and compensating for leaks are presented as well as a number of techniques for operating the pumping system.

Abstract: A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid are pumped through the system. A number of techniques for detecting and compensating for leaks are presented as well as a number of techniques for operating the pumping system.

Abstract: A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid are pumped through the system. A number of techniques for detecting and compensating for leaks are presented as well as a number of techniques for operating the pumping system.

Abstract: There is provided a method that includes, (a) monitoring a pressure on a fluid being conveyed through an intake tube into a chamber by a pump, (b) determining a deviation of the pressure from a predefined value, (c) determining a blockage of the intake tube based on the deviation, and (d) determining an amount of an adjustment of a parameter of the pump to compensate for the blockage.

Abstract: A handling unit that comprises a first clamping element and a second clamping element, and an actuation mechanism adapted for driving at least one of the clamping elements. When the at least one of the clamping elements is driven to a first position, a microfluidic device may be placed between the clamping elements or taken out of the clamping elements, and when the at least one of the clamping elements is driven to a second position, the microfluidic device is gripped and fastened by the clamping elements.

Abstract: A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid are pumped through the system. A number of techniques for detecting and compensating for leaks are presented as well as a number of techniques for operating the pumping system.

Abstract: A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid are pumped through the system. A number of techniques for detecting and compensating for leaks are presented as well as a number of techniques for operating the pumping system.

Abstract: A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid are pumped through the system. A number of techniques for detecting and compensating for leaks are presented as well as a number of techniques for operating the pumping system.

Abstract: A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid are pumped through the system. A number of techniques for detecting and compensating for leaks are presented as well as a number of techniques for operating the pumping system.

Abstract: A liquid delivery system having at least one channel, at least one valve within that channel, at least one flow sensing device within that channel, and a pressure source downstream of the valve capable for generating variable pressures.

Abstract: A sample injector for a liquid analysis device includes a multi-route switching valve and a sample conduit. The valve alternatively connects a solvent pump directly to a chromatographic column or via a sample conduit. The sample injector further has a flush solvent delivery device. The flush solvent delivery device delivers at least one flush solvent to the sample conduit of the sample injector. The sample injector also has a sample intake device. The sample intake device provides liquid sample to the sample conduit.