Patents by Inventor Hans-Georg Wisniewski
Hans-Georg Wisniewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9939450Abstract: This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid.Type: GrantFiled: November 10, 2014Date of Patent: April 10, 2018Assignees: New York University, Duke University Medical CenterInventors: Philip A. Band, Hans-Georg Wisniewski, Virginia Byers Kraus
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Publication number: 20150204888Abstract: This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid.Type: ApplicationFiled: November 10, 2014Publication date: July 23, 2015Applicants: DUKE UNIVERSITY MEDICAL CENTER, NEW YORK UNIVERSITYInventors: Philip A. BAND, Hans-Georg WISNIEWSKI, Virginia BYERS KRAUS
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Patent number: 8883427Abstract: This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid.Type: GrantFiled: June 29, 2011Date of Patent: November 11, 2014Assignees: New York University, Duke University Medical CenterInventors: Philip A. Band, Hans-Georg Wisniewski, Virginia Byers Kraus
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Biocompatible materials containing stable complexes of TSG-6 and hyaluronan and method of using same
Patent number: 8420601Abstract: The present invention provides a biocompatible material in the form of a water insoluble cross-linked gel, which contains a stable complex of TNF-stimulated gene 6 protein (TSG-6) and hyaluronan.Type: GrantFiled: November 18, 2011Date of Patent: April 16, 2013Assignees: New York University, Polytechnic Institute of NYUInventors: Hans-Georg Wisniewski, Mary K. Cowman, Philip Band -
BIOCOMPATIBLE MATERIALS CONTAINING STABLE COMPLEXES OF TSG-6 AND HYALURONAN AND METHOD OF USING SAME
Publication number: 20120064150Abstract: The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable comples of TNF-stimulated gene 6 protein (TSG-6) and hyaluronan.Type: ApplicationFiled: November 18, 2011Publication date: March 15, 2012Applicant: NEW YORK UNIVERSITY POLYTECHNIC INSTITUTE OF NYUInventors: Hans-Georg WISNIEWSKI, Mary K. Cowman, Philip Band -
Publication number: 20120028369Abstract: This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid.Type: ApplicationFiled: June 29, 2011Publication date: February 2, 2012Applicants: DUKE UNIVERSITY MEDICAL CENTER, NEW YORK UNIVERSITYInventors: Philip A. BAND, Hans-Georg WISNIEWSKI, Virginia Byers Kraus
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Patent number: 8093365Abstract: The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable complexes of TNF-stimulated gene protein (TSG-6) and hyaluronan.Type: GrantFiled: February 17, 2009Date of Patent: January 10, 2012Assignees: New York University, Polytechnic Institute of NYUInventors: Hans-Georg Wisniewski, Mary K. Cowman, Philip Band
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BIOCOMPATIBLE MATERIALS CONTAINING STABLE COMPLEXES OF TSG-6 AND HYALURONAN AND METHOD OF USING SAME
Publication number: 20090226499Abstract: The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable comples of TNF-stimulated gene protein (TSG-6) and hyaluronan.Type: ApplicationFiled: February 17, 2009Publication date: September 10, 2009Applicants: NEW YORK UNIVERSITY, POLYTECHNIC INSTITUTE OF NYUInventors: Hans-Georg WISNIEWSKI, Mary K. Cowman, Philip Band -
Patent number: 6518401Abstract: TSG protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.Type: GrantFiled: March 6, 2001Date of Patent: February 11, 2003Assignee: New York UniversityInventors: Tae Ho Lee, Hans-Georg Wisniewski, Jan Vilcek
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Publication number: 20020090708Abstract: TSG protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.Type: ApplicationFiled: March 6, 2001Publication date: July 11, 2002Applicant: New York UniversityInventors: Tae Ho Lee, Hans Georg Wisniewski, Jan Vilcek
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Patent number: 6313091Abstract: Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a protein molecule, termed TSG-6, in connective tissue cells. TSG-6, or pharmaceutical compositions containing TSG-6, can be used to treat inflammatory diseases and disorders and cancer-related pathologies. Inflammatory diseases and disorders, or cancer related pathologies, can also be treated by introducing human cells transfected with a DNA molecule containing a DNA segment encoding TSG-6 protein, into humans to express therapeutically effective amounts of TSG-6 in vivo or by introducing a vector carrying a DNA segment encoding TSG-6 protein directly into humans in vivo.Type: GrantFiled: May 20, 1998Date of Patent: November 6, 2001Assignee: New York UniversityInventors: Hans-Georg Wisniewski, Jan Vilcek, Bruce Cronstein
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Patent number: 6210905Abstract: TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.Type: GrantFiled: December 7, 1998Date of Patent: April 3, 2001Assignee: New York UniversityInventors: Tae Ho Lee, Hans-Georg Wisniewski, Jan Vilcek
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Patent number: 5846763Abstract: TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.Type: GrantFiled: May 13, 1994Date of Patent: December 8, 1998Assignee: New York UniversityInventors: Tae Ho Lee, Hans-Georg Wisniewski, Jan Vilcek
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Patent number: 5386013Abstract: Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a protein molecule, termed TSG-6, in connective tissue cells. The TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided. Antibodies specific for the TSG-6 protein are disclosed, as is a method for detecting the presence of TSG-6 protein in a biological sample, using the antibody or another molecule capable of binding to TSG-6 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein, a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-6 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.Type: GrantFiled: March 1, 1993Date of Patent: January 31, 1995Assignee: New York UniversityInventors: Tae H. Lee, Hans-Georg Wisniewski, Jan Vilcek