Abstract: Disclosed are methods for the preparation of ligands for complexes, methods for preparing complexes and complexes having those ligands. Also provided is the use of a complex as a catalyst in a method of synthesis.

Abstract: The present invention provides a metallocenyl compound of formula (I). Ra, Rb, Rc, Rd, Re, Rf, M, m, n, j, k, Y and Z and * are as described in the specification. The invention also provides a process for the preparation of the complexes, a process for increasing the optical purity of a compound of formula (II) and a process for the asymmetric transfer hydrogenation (ATH) of a metallocenyl compound of formula (V) to a metallocenyl compound of formula (IV).

Abstract: The present invention relates to improved processes for the preparation of ruthenium or osmium complexes comprising acetate ligands, in particular, ruthenium complexes.

Abstract: The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.

Abstract: The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.

Abstract: The present invention provides substituted tridentate benzo[h]quinoline ligands and complexes thereof. The invention also provides the preparation of the ligands and the respective complexes, as well as to processes for using the complexes in catalytic reactions.

Abstract: The present invention relates to improved processes for the preparation of ruthenium or osmium complexes comprising acetate ligands, in particular, ruthenium complexes.

Abstract: A process for the synthesis of a cationic rhodium complex comprises the steps of: (a) forming a mixture of a rhodium-diolefin-1,3-diketonate compound and a phosphorus ligand in a ketone solvent, (b) mixing an acid with the mixture to form a solution of the cationic rhodium complex, (c) evaporating at least a portion of the solvent from the solution, (d) optionally, treating the resulting complex with an ether, and (e) treating the resulting complex with an alcohol. The complex may be recovered and used as a catalyst, for example in hydrogenation reactions.

Abstract: Disclosed are methods for the preparation of ligands for complexes, methods for preparing complexes and complexes having those ligands. Also provided is the use of a complex as a catalyst in a method of synthesis.

Abstract: The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.

Abstract: The present invention relates to a process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.

Abstract: The present invention relates to the ruthenium complexes comprising paracyclophane and carbonyl ligands, methods for the preparation thereof and uses of the complexes in isomerization, hydrogenation, transfer hydrogenation, hydroformylation and carbonylation reactions.

Abstract: The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.

Abstract: Ethereal solvents to precipitate [ruthenium (arene) (phosphorus ligand) (halogen)] complexes result in complexes having reduced stability. The stability of [ruthenium (arene) (phosphorus ligand) (halogen)] complexes is improved when the complexes are triturated or precipitated with at least one alkane. The at least one alkane can be pentane isomers, hexane isomers, heptane isomers, octane isomers and combinations thereof.

Abstract: The present invention relates to the ruthenium complexes comprising paracyclophane and carbonyl ligands, methods for the preparation thereof and uses of the complexes in isomerisation, hydrogenation, transfer hydrogenation, hydroformylation and carbonylation reactions.

Abstract: A process is described for the synthesis of a cationic [rhodium diolefin phosphorus ligand] complex comprising the steps of: (a) reacting a rhodium-diolefin-1,3-diketonate and an acid in a ketone solvent, (b) adding a stabilising olefin to form a stabilised cationic rhodium compound, and (c) mixing a phosphorus ligand with the solution of the stabilised cationic rhodium compound to form a solution of the cationic [rhodium diolefin phosphorus ligand] complex. The solution may be used directly or the complex recovered. In one embodiment, the solution may be combined with a co-solvent and the ketone removed to give a new catalyst solution, from which the complex may be recovered.

Abstract: The present invention relates to a process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.

Abstract: A process is described for the preparation of a solid cationic [ruthenium (arene) (phosphorus ligand) (halogen)] complex comprising the step of treating the complex with at least one alkane. Further described is a process for preparing a cationic [ruthenium (arene) {4,4?-bis(disubstituted-phosphino)-3,3?-bipyridine} (halogen)] complex comprising the step of reacting [ruthenium (arene) (halogen) 2]2 and a 4,4?-bis(disubstituted-phosphino)-3,3?-bipyridine ligand in a solvent consisting of at least one alcohol.

Abstract: A process is described for the synthesis of a cationic [rhodium diolefin phosphorus ligand] complex comprising the steps of: (a) reacting a rhodium-diolefin-1,3-diketonate and an acid in a ketone solvent, (b) adding a stabilising olefin to form a stabilised cationic rhodium compound, and (c) mixing a phosphorus ligand with the solution of the stabilised cationic rhodium compound to form a solution of the cationic [rhodium diolefin phosphorus ligand] complex. The solution may be used directly or the complex recovered. In one embodiment, the solution may be combined with a co-solvent and the ketone removed to give a new catalyst solution, from which the complex may be recovered.

Abstract: A process for the synthesis of a cationic rhodium complex comprises the steps of: (a) forming a mixture of a rhodium-diolefin-1,3-diketonate compound and a phosphorus ligand in a ketone solvent, (b) mixing an acid with the mixture to form a solution of the cationic rhodium complex, (c) evaporating at least a portion of the solvent from the solution, (d) optionally, treating the resulting complex with an ether, and (e) treating the resulting complex with an alcohol. The complex may be recovered and used as a catalyst, for example in hydrogenation reactions.