Patents by Inventor Hans-Heinrich Gruenhagen

Hans-Heinrich Gruenhagen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5849941
    Abstract: A process for producing solutions of active substances of low solubility, which comprises (1) dissolving the active substance with a phospholipid and a water-soluble lipid in an organic solvent, (2) evaporating the resulting solution to dryness, (3) taking up the residue in a strongly acidic buffer and stirring at elevated temperature until a colloidal solution is produced, (4) cooling the colloidal solution and adjusting to a pH of 6-7 and sterilizing. Particularly suitable for the process are lipids of the formula ##STR1## wherein m, a, b, x and y have the meanings indicated in the description.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: December 15, 1998
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Cynthia Romerdahl, Hans-Heinrich Gruenhagen
  • Patent number: 5720973
    Abstract: A process for producing solutions of active substances of low solubility, which comprises (1) dissolving the active substance with a phospholipid and a water-soluble lipid in an organic solvent, (2) evaporating the resulting solution to dryness, (3) taking up the residue in a strongly acidic buffer and stirring at elevated temperature until a colloidal solution is produced, (4) cooling the colloidal solution and adjusting to a pH of 6-7 and sterilizing. Particularly suitable for the process are lipids of the formula ##STR1## wherein m, a, b, x and y have the meanings indicated in the description.
    Type: Grant
    Filed: July 19, 1995
    Date of Patent: February 24, 1998
    Assignee: Knoll Aktiengesellschaft
    Inventors: Joerg Rosenberg, Cynthia Romerdahl, Hans-Heinrich Gruenhagen
  • Patent number: 5370877
    Abstract: .alpha.-Aminocarboxylic acid derivatives of the formula: ##STR1## where n, X, Y and Z have the meanings stated in the description, and their preparation are described. The compounds are used in a method for improving delivery and reducing toxicity of biologically active substances by encapsulation of the biologically active substance with the above compounds.
    Type: Grant
    Filed: March 31, 1993
    Date of Patent: December 6, 1994
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Hans-Heinrich Gruenhagen, Dieter Lenke
  • Patent number: 4958046
    Abstract: Hydroxypropafenone glycerides of the formula I ##STR1## where R is n-propyl or 1,1-dimethylpropyl,x is 2 or 3,y is 12, 14, 16, 18 or 20, anda and b differ from one another and are 0 or 1,as well as the stereoisomers thereof and the preparation thereof are described. The compounds are suitable as active substances for antiarrhythmics.
    Type: Grant
    Filed: September 19, 1989
    Date of Patent: September 18, 1990
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Juergen Heberger, Hans-Heinrich Gruenhagen, Egon Brode, Gerda von Philipsborn